Huntington’s Disease News and Research

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Why can SARS-CoV-2 infection cause neurological and cardiovascular symptoms?

Researchers from Columbia University Vagelos College of Physicians & Surgeons, USA, present results linking oxidative stress and the activation of a biochemical pathway associated with Alzheimer’s disease to SARS-CoV-2 infection.

22 Feb 2021

Research shows potential new therapeutic strategy for slowing down Huntington's disease

Scientists have described a potential new therapeutic strategy for slowing down early-stage Huntington's disease in a new study published today in eLife.

9 Jun 2020

New study reveals complex role of immune-system molecule in Huntington's disease

More than a decade before people with Huntington's disease show symptoms, they can exhibit abnormally high levels of an immune-system molecule called interleukin-6 (IL-6), which has led many researchers to suspect IL-6 of promoting the eventual neurological devastation associated with the genetic condition.

26 May 2020

Recognizing CDKL5 Deficiency Disorder

News-Medical speaks to Dr. Dan Lavery about the LouLou Foundation, a non-profit organization dedicated to CDLK5 Deficiency Disorder.

17 Mar 2020

Scientists reveal ability to reverse Huntington's disease-causing DNA repeat mutations in the lab

Neurodegenerative diseases, like Huntington's disease and myotonic dystrophy, are often referred to as DNA repeat diseases, named because of long repeated sequences in the DNA of patients. Increasing repeat expansion length in the affected tissues contribute to earlier age of disease onset and worsen the progression and severity of the disease over time.

27 Feb 2020

Study finds higher suicide rate among people with neurological disorders

Neurological disorders may impact one’s mental health, a new study says as researchers found that there is a higher rate of suicide among individuals living with neurological disorders.

4 Feb 2020

Scientists shed new light on neuronal circuits that acquire and update voluntary actions

Two types of neuronal circuit in the brain that acquire and update voluntary actions are much more intertwined than previously thought.

3 Feb 2020

New genetic screen for Huntington’s disease

Huntington’s disease is a genetic disease that is debilitating and progressive leading to severe brain damage and eventual death. In patients with this autosomal dominant disease, there is presence of a protein called the Huntingtin protein that forms clumps within the brain leading to the symptoms of the disease.

30 Jan 2020

New AI tool predicts disease progression and evolution in neurodegenerative disorders

Researchers have found that testing blood using an artificial intelligence algorithm successfully predicted disease progression in neurodegenerative disorders.

28 Jan 2020

Research team identifies new roles for Huntington's Disease protein

A Duke University research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative disorder known as Huntington's Disease.

21 Jan 2020

New technique could lead to better diagnosis and effective tracking of Huntington’s disease

Researchers at the universities of Southampton and Cambridge have developed a new technique to analyze biochemical changes unique to Huntington's disease.

17 Dec 2019

University Of Iowa wins $18 million grant to continue study on Huntington's disease

Peg Nopoulos, MD, chair of psychiatry and professor of psychiatry, neurology, and pediatrics in the University of Iowa Carver College of Medicine, has received a five-year, $18 million grant from the National Institute of Neurological Disorders and Stroke to continue and expand a decade-long study on brain development in children at risk for developing Huntington's Disease.

11 Dec 2019

Scientists evaluate mouse models used for developing new treatments for Huntington's disease

Huntington's disease (HD) is an incurable and fatal hereditary disease. Developing disease-modifying drugs to treat patients with HD depends on studying them in animal models. Scientists evaluated the mouse models used for developing new treatments for mood disorders in HD and recommended which of these models are most relevant to their studies.

11 Dec 2019

Huntington's disease patients need to better understand the risks and benefits of new therapies

For patients with Huntington's disease (HD), clinical trials can offer hope when there are no treatments available despite unknowns about whether the therapy will work or is safe.

10 Dec 2019

Researchers uncover novel pathogenic mechanism in Huntington’s disease

Researchers from the Institute of Neurosciences of the University of Barcelona and the August Pi i Sunyer Biomedical Research Institute described a mechanism, the increase of proteinaceous synthesis, which takes part in the degeneration of the type of neurons that are affected in Huntington's disease, a genetic neurodegenerative disease.

20 Nov 2019

New CRISPR genome “prime editing” system

Gene editing to correct genetic faults and removing the risk of hereditary diseases may soon become reality. Researchers have come up with a new gene editing technology that could help patients with sickle cell anaemia and up 89 percent of other genetic defects.

22 Oct 2019

Pluripotent stem cells help advance understanding of how Huntington's disease develops

Huntington's disease (HD) is a fatal hereditary disease for which there is no cure. A novel study from Cedars-Sinai Medical Center, Los Angeles, using pluripotent stem cells advances understanding of how the disease develops and may help pave the way for identifying pathways for future treatments.

21 Oct 2019

Patterns unique to the striatum observed in people with Huntington's disease

The part of the brain that selectively degenerates in people with Huntington's disease (HD), called the striatum, is almost entirely destroyed in the late stages of the disease. Brain samples from mutant HD gene positive individuals who had not yet developed symptoms by time of death are extremely rare. As a consequence, very little is known about the active disease process that causes the devastating symptoms of HD.

21 Oct 2019

UCLA research identifies potential strategy that may halt Huntington's disease

A new study examining the role that star-shaped brain cells called astrocytes play in Huntington's disease has identified a potential strategy that may halt the disease and repair some of the damage it causes.

16 Oct 2019

New technology helps trace the origin of Huntington's disease

The first signs of Huntington's, an inherited disease that slowly deteriorates bodies and minds, don't typically surface until middle age.

18 Sep 2019