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Childhood affective features may guide adult psychiatric diagnosis

Childhood affective features may guide adult psychiatric diagnosis

Clinical features that can appear many years ahead of a psychiatric diagnosis may help doctors to predict whether patients will develop bipolar disorder or unipolar depression, say researchers. [More]
Special receptor signalling mediates astrocytic hyperactivity in  Alzheimer's disease mouse model

Special receptor signalling mediates astrocytic hyperactivity in Alzheimer's disease mouse model

It has long been known that astrocytes change their shapes as a consequence of Alzheimer's. Cells located near the "plaques", as the protein deposits typical for this disease are called, grow in size and form additional extensions. [More]
New mouse model shows how mutated gene impairs neuronal development in individuals with autism

New mouse model shows how mutated gene impairs neuronal development in individuals with autism

Geneticists at Heidelberg University Hospital's Department of Molecular Human Genetics have used a new mouse model to demonstrate the way a certain genetic mutation is linked to a type of autism in humans and affects brain development and behavior. [More]
HLD-200 successfully meets primary endpoint in Phase III study

HLD-200 successfully meets primary endpoint in Phase III study

Highland Therapeutics Inc., a pharmaceutical company, today announced that its wholly owned subsidiary, Ironshore Pharmaceuticals & Development, Inc. has reported positive top-line results from its recently completed Phase III study. [More]
Mothers, teachers lack awareness about ADHD symptoms in tween girls

Mothers, teachers lack awareness about ADHD symptoms in tween girls

According to a new survey released today, nearly 50 percent of mothers of tween girls who have been diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) reported that they had first attributed their daughters' behavior to "normal" adolescent struggles, and 59 percent reported that they initially hesitated to seek help from a doctor for their daughter. [More]
Mice may hold clues in development of ADHD, autism and bipolar disorder

Mice may hold clues in development of ADHD, autism and bipolar disorder

A darting mouse may hold an important clue in the development of Attention Deficit Hyperactivity Disorder (ADHD), autism and bipolar disorder, according to a study by a Vanderbilt University-led research team recently published in the Proceedings of the National Academy of Sciences. [More]
McLean Hospital lab explores use of stem cell therapy to treat epilepsy

McLean Hospital lab explores use of stem cell therapy to treat epilepsy

McLean Hospital and Harvard Stem Cell Institute scientists have new evidence that stem cell transplantation could be a worthwhile strategy to help epileptics who do not respond to anti-seizure drugs. [More]
Researchers discover link between seizures and migraines

Researchers discover link between seizures and migraines

Seizures and migraines have always been considered separate physiological events in the brain, but now a team of engineers and neuroscientists looking at the brain from a physics viewpoint discovered a link between these and related phenomena. [More]
Sleep problems very common among young children receiving treatment for psychiatric disorders

Sleep problems very common among young children receiving treatment for psychiatric disorders

John Boekamp, Ph.D., clinical director of the Pediatric Partial Hospital Program at Bradley Hospital recently led a study that found sleep difficulties - particularly problems with falling asleep - were very common among toddlers and preschool-aged children who were receiving clinical treatment for a wide range of psychiatric disorders. [More]
Genetic risk for ADHD contributes to language, attention deficits in general population

Genetic risk for ADHD contributes to language, attention deficits in general population

Are deficits in attention limited to those with attention-deficit/hyperactivity disorder (ADHD) or is there a spectrum of attention function in the general population? [More]
Actavis seeks FDA approval to market generic version of Quillivant XR

Actavis seeks FDA approval to market generic version of Quillivant XR

Actavis plc today confirmed that it has filed an Abbreviated New Drug Application (ANDA) with the U.S. Food and Drug Administration seeking approval to market Methylphenidate Hydrochloride for Extended-release Oral Suspension, 5 mg/mL. Actavis' ANDA product is a generic version of Pfizer and Tris Pharma's Quillivant XR®, which is a central nervous system stimulant indicated for the treatment of Attention Deficit Hyperactivity Disorder. [More]
ADHD increases major depression to bipolar disorder conversion

ADHD increases major depression to bipolar disorder conversion

Young people with major depression have an increased risk of conversion to bipolar disorder if they have comorbid attention deficit/hyperactivity disorder, suggest findings from a longitudinal follow-up study. [More]
NeuroSigma, VA partner to evaluate eTNS system for TBI patients in Phase I clinical trial

NeuroSigma, VA partner to evaluate eTNS system for TBI patients in Phase I clinical trial

NeuroSigma, Inc., a California-based life sciences company focused on commercialization of its non-invasive Monarch eTNS System for the treatment of neurological and neuropsychiatric disorders, today announced that it has entered into a Cooperative Research and Development Agreement (CRADA) with the U.S. Veterans Affairs for a clinical trial to evaluate the benefits of non-invasive, external Trigeminal Nerve Stimulation (eTNS) for patients with traumatic brain injury (TBI) in a Phase I clinical trial. [More]

Early childhood neglect associated with changes in brain structure

Under the rule of dictator Nicolae Ceausescu, thousands of Romanian children were placed in overcrowded orphanages with bleak conditions and minimal human contact. Even after the 1989 revolution, the legacy of institutionalization continued. Only recently has research and public concern over early childhood environments caused changes in policies. [More]
Shire receives FDA guidance on regulatory path for investigational compound SHP 465

Shire receives FDA guidance on regulatory path for investigational compound SHP 465

Shire plc today announced that it has received further guidance from the U.S. Food and Drug Administration on the regulatory path for SHP 465 (triple-bead mixed amphetamine salts MAS), an investigational oral stimulant medication being evaluated as a potential treatment for Attention-Deficit/Hyperactivity Disorder (ADHD) in adults. [More]
Specific perceptual learning deficit associated with Fragile X Syndrome

Specific perceptual learning deficit associated with Fragile X Syndrome

Researchers at Children's Hospital Los Angeles have described for the first time a specific perceptual learning deficit in mice with a mutation of the same gene as found in children with Fragile X Syndrome (FXS). [More]
Brain & Behavior Research Foundation to honor 8 scientists for achievements in psychiatric research

Brain & Behavior Research Foundation to honor 8 scientists for achievements in psychiatric research

The Brain & Behavior Research Foundation will honor eight scientists with its 2014 Outstanding Achievement Prizes for work delving into psychiatric disorders that affect one in four people. The awards, which celebrate the transformative power of neuroscience and psychiatric research to improve the lives of people with mental illness, will be presented at the Foundation's National Awards Dinner at the Pierre Hotel. [More]
Patrick F. Sullivan honored with 2014 Lieber Prize for making contributions to schizophrenia research

Patrick F. Sullivan honored with 2014 Lieber Prize for making contributions to schizophrenia research

Patrick F. Sullivan, MD, FRANZCP, M. Hayworth & Family Distinguished Professor of Psychiatry and Professor of Genetics and Psychiatry at the University of North Carolina School of Medicine, is one of two researchers awarded the 2014 Lieber Prize for Outstanding Achievement in Schizophrenia Research. [More]
Study examines relationship between maternal iron intake and offspring autism risk

Study examines relationship between maternal iron intake and offspring autism risk

Mothers of children with autism are significantly less likely to report taking iron supplements before and during their pregnancies than the mothers of children who are developing normally, a study by researchers with the UC Davis MIND Institute has found. [More]
Researchers identify control mechanism for mood disorders

Researchers identify control mechanism for mood disorders

Researchers at University of California, San Diego School of Medicine have identified a control mechanism for an area of the brain that processes sensory and emotive information that humans experience as "disappointment." [More]