Hypercholesterolemia News and Research

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Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood. Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods that come from animals (particularly egg yolks, meat, poultry, fish, and dairy products). The body needs this substance to build cell membranes, make certain hormones, and produce compounds that aid in fat digestion. Too much cholesterol, however, increases a person's risk of developing heart disease.

People with hypercholesterolemia have a high risk of developing a form of heart disease called coronary artery disease. This condition occurs when excess cholesterol in the bloodstream is deposited in the walls of blood vessels, particularly in the arteries that supply blood to the heart (coronary arteries). The abnormal buildup of cholesterol forms clumps (plaque) that narrow and harden artery walls. As the clumps get bigger, they can clog the arteries and restrict the flow of blood to the heart. The buildup of plaque in coronary arteries causes a form of chest pain called angina and greatly increases a person's risk of having a heart attack.

Inherited forms of hypercholesterolemia can also cause health problems related to the buildup of excess cholesterol in other tissues. If cholesterol accumulates in tendons, it causes characteristic growths called tendon xanthomas. These growths most often affect the Achilles tendons and tendons in the hands and fingers. Yellowish cholesterol deposits under the skin of the eyelids are known as xanthelasmata. Cholesterol can also accumulate at the edges of the clear, front surface of the eye (the cornea), leading to a gray-colored ring called an arcus cornealis.

Being overweight may independently increase risk for developing coronary heart disease

Being moderately overweight or obese appears to increase the risk for developing coronary heart disease events independent of traditional cardiovascular risk factors, according to a meta-analysis of previously published studies in the September 10 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

11 Sep 2007

Statin drugs may delay progressive artery damage in children

Starting statin therapy as young as age 8 safely and effectively delays the early artery damage caused by familial hypercholesterolemia (FH), according to a Dutch study reported in the Aug.7th print issue of Circulation: Journal of the American Heart Association.

7 Aug 2007

One-third to nearly one-half of all children and adolescents should be tested for cholesterol levels

According to the AHA, the physicians who care for these at-risk youth face an unexpected obstacle -- their parents. The AHA finds "low levels of parental compliance with both cholesterol screening and intervention."

10 May 2007

Schering-Plough announces ZETIA spproved in Japan

Schering-Plough Corporation has announced that Schering-Plough K.K., the company's country operation in Japan, has received marketing approval for ZETIA (ezetimibe), a novel cholesterol-lowering agent that inhibits the absorption of cholesterol in the intestine.

20 Apr 2007

Soy foods among the smartest choices of foods that lower LDL cholesterol

Research from Dr. Walter Willett of Harvard University, Dr. Alice Lichtenstein of Tufts University, and the National Institute of Health and Nutrition in Japan confirms findings of the Food and Drug Administration (FDA) health claim for soy protein and heart disease.

11 Apr 2007

Addition of torcetrapib to statin therapy has no benefit for atherosclerosis progression

For some patients with high cholesterol, even the most aggressive treatment with statin drugs fails to prevent coronary artery disease.

2 Apr 2007

Statins can significantly reduce the incidence of stroke, myocardial infarction

The study, presented at CHEST 2006, the 72nd annual international scientific assembly of the American College of Chest Physicians (ACCP), showed that statins notably reduced such incidences in these nonrevascularized patients with chronic high cholesterol, as well.

23 Oct 2006

Nutritional supplement policosanol does not lower cholesterol levels

A new study suggests that use of the nutritional supplement policosanol does not lower cholesterol levels any more than placebo, apparently contradicting the results of previous studies.

23 May 2006

Major biomarker candidates for Alzheimer's disease explored

Alzheimer's disease - specific biomarkers clearly are needed for the differential diagnosis of cognitive impairment in the elderly.

8 Mar 2006

"Freshman Fifteen" phenomenon is exaggerated

A common, but often undocumented, truism among college students is that they are likely to gain 15 pounds during their freshman year. But now a new study at Rutgers' Cook College has found that the "Freshman Fifteen" phenomenon is exaggerated.

7 Feb 2006

Current clinical practice guidelines are not written with older adults with multiple illnesses in mind

The aging of the population and the increasing prevalence of chronic diseases pose challenges to the development and application of clinical practice guidelines (CPGs), according to background information in the article. In 1999, 48 percent of Medicare beneficiaries aged 65 years or older had at least 3 chronic medical conditions and 21 percent had 5 or more.

10 Aug 2005

Obesity is associated with an impairment of coronary circulatory function

A team of University of California, Los Angeles researchers found that positron emission tomography (PET) can provide important information on the relationship between heart function and obesity. Their findings were reported at the Society of Nuclear Medicine's 52nd Annual Meeting June 18–22 in Toronto.

20 Jun 2005

Increase in heart surgery mortality from SSRIs or depression?

Duke University Medical Center researchers have found that patients who were using a class of anti-depression drugs known as selective serotonin reuptake inhibitors (SSRI) prior to undergoing coronary artery bypass surgery have significantly higher death and rehospitalization rates up to five years after the procedure than patients who were not on SSRIs.

26 May 2005

Targeted Genetics announces new patent for Hyperlipidemia

Targeted Genetics Corporation announced today issuance of U.S. patent #6,887,463, entitled, "Methods and Compositions for Gene Therapy for the Treatment of Defects in Lipoprotein Metabolism."

11 May 2005

FDA issues information on the risks and benefits of Crestor

The U.S. Food and Drug Administration (FDA), today issued public health advice, patient information, and professional healthcare information on the risks and benefits of Crestor (Rosuvastatin calcium), a cholesterol-lowering drug.

2 Mar 2005

Biochip for detection of inflammatory bowel disease

At the III International Symposium on Advanced Therapy for Chronic Inflammatory Bowel Disease, held in Madrid, the biotechnological company, Progenika, presented a DNA-chip the purpose of which is the optimisation of the diagnosis, prognosis and treatment of patients with inflammatory bowel disease (Crohn’s disease and Ulcerous Colitis).

26 Jan 2005

Israeli developed fruit called pomelit, lowers blood cholesterol

People who eat the Israeli-developed fruit known in Hebrew as pomelit (a cross between a grapefruit and a pomelo) or drink its juice regularly will be able to lower their blood cholesterol and increase their blood antioxidant activity, thus improving their chances of preventing blocked heart arteries and heart attacks, says a researcher at the Hebrew University of Jerusalem.

30 Nov 2004

FDA approval for VYTORIN for the treatment of high LDL cholesterol (LDL-C)

Merck/Schering-Plough Pharmaceuticals has announced that the U.S. Food and Drug Administration has approved VYTORIN™ (ezetimibe/simvastatin) for the treatment of high LDL cholesterol (LDL-C) in patients with primary hypercholesterolemia or mixed hyperlipidemia as adjunctive therapy to diet when diet alone is not enough.

26 Jul 2004

Mediterranean diet lowers levels of markers for inflammation and coagulation which have been linked to heart disease

“The benefits of this diet are very well known, but the mechanism is not well understood. We believe this is the first time it has been reported that the potential mechanism goes through the inflammation process,” said Demosthenes B. Panagiotakos, MSc, PhD with Harokopio University in Athens, Greece.

7 Jul 2004

Completion of the sequencing of human chromosome 19

The United States Department of Energy (DOE) Joint Genome Institute (JGI) and Stanford University report today the completion of the sequencing of human chromosome 19, the most gene-rich of all the human chromosomes. This achievement is described in the April 1, 2004 edition of the journal Nature.

7 Apr 2004