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Scientists develop amplicon-based sequencing method for genomic surveillance of human monkeypox virus

A team of US-based scientists has developed an amplicon-based sequencing method for the human monkeypox virus. The

19 Oct 2022

Rapid and robust pipeline for developing mRNA vaccines for future SARS-CoV-2 variants

A recent study under review at the journal Scientific Reports and currently available on the Research Square* preprint server reported the development of a robust pipeline for fabricating an mRNA vaccine portfolio to combat current and future coronavirus outbreaks, other infectious diseases, and cancer.

19 Oct 2022

Scientists develop a pseudovirus system to deep mutational scan the full SARS-CoV-2 spike

A pseudovirus system based on deep mutational scanning determines how SARS-CoV-2 mutations can affect its ability to escape neutralization.

18 Oct 2022

DNA metagenomic analyses of clinical samples from Monkeypox virus-infected individuals

Researchers analyzed genomic sequences of MPXV obtained from 18 patients who contracted MPXV infection between June and July 2022.

30 Sep 2022

Novel tests detect common cancer signals across over 50 types of cancer

Cancer doctors, care providers and payers need to get ready for a major shift in early cancer detection that will affect almost every stage of cancer diagnosis and treatment. New data supporting the accuracy of multi-cancer early detection (MCED) blood testing (1), presented at the ESMO Congress 2022, have major implications for future cancer care provision, said Fabrice André, ESMO 2022 Scientific Co-Chair.

12 Sep 2022

Pollutant particles in the air trigger lung cancer in non-smokers

A new mechanism has been identified through which very small pollutant particles in the air may trigger lung cancer in people who have never smoked, paving the way to new prevention approaches and development of therapies, according to late-breaking data [to be] reported at the ESMO Congress 2022 by scientists of the Francis Crick Institute and University College London, funded by Cancer Research UK. The particles, which are typically found in vehicle exhaust and smoke from fossil fuels, are associated with non-small cell lung cancer (NSCLC) risk, accounting for over 250,000 lung cancer deaths globally per year.

12 Sep 2022

Next-generation sequencing system yields results comparable to traditional diagnostics

In the pursuit of accurate diagnoses for illnesses, doctors have traditionally used multiple methods — including culturing patient samples on a wide variety of media, reviewing countless medical records and analyzing clinical data using complex mathematical algorithms — to try to identify the bacterium, virus, fungus or other pathogen responsible for an infection.

10 Aug 2022

Study: Genes involved in coronary heart disease may be nearly the same for everyone

The genes involved in coronary heart disease, the most common form of heart disease, appear to be nearly the same for everyone, according to a VA study.

3 Aug 2022

Older age and smoking linked to increased risk of developing any cancer, study shows

A new large study led by researchers at the American Cancer Society (ACS) shows older age and smoking are the two most important risk factors associated with a relative and absolute five-year risk of developing any cancer.

3 Aug 2022

Epigenetic age acceleration could be used as a biomarker to estimate functional and cognitive aging

A first-of-its-kind study of 1,813 older women suggests that the accelerated biological aging of the body -; epigenetic age acceleration specifically -; is associated with lower odds of living to be 90 years old and also being physically mobile and having intact mental function.

27 Jul 2022

Biden’s FTC has blocked 4 hospital mergers and is poised to thwart more consolidation attempts

Fresh off the Federal Trade Commission's successful challenges to four hospital mergers, the Biden administration's new majority on the commission is primed to more aggressively combat consolidation in the health care industry than it has in past years.

18 Jul 2022

Phase I clinical trial of new blocking antibody therapy shows promising results for the treatment of advanced medulloblastoma

Effective and safe treatments are needed for medulloblastoma-;the most common type of cancerous brain tumor in children-;especially for patients whose cancer has spread to the spinal cord.

14 Jul 2022

New high-throughput genomic array offers an in-depth view of the mouse epigenome

A new high-throughput genomic array offers an unprecedented look into the mouse epigenome, giving researchers an in-depth view into the basis of health and disease in a vital model organism.

13 Jul 2022

Beckman Coulter Life Sciences launches Biomek NGeniuS Next Generation Library Prep System

Beckman Coulter Life Sciences, a global leader in laboratory workflow automation and innovation, and a company of Danaher Corporation, unleashes the power of next generation sequencing and makes it more accessible for research labs of all sizes with the launch of the Biomek NGeniuS liquid handling system.

From Beckman Coulter Life Sciences - Flow Cytometry 29 Jun 2022

An integrated molecular diagnostic approach for detecting SARS-CoV-2 variants

Researchers developed an integrated approach combining NGS, molecular barcoding, machine learning, and bioinformatics to enable high-throughput detection of SARS-CoV-2 variants.

23 Jun 2022

Study identifies interesting sequence features in SARS-CoV-2 at start of COVID pandemic

In a recent study posted to the bioRxiv* pre-print server, researchers studied the sequence data from the coronavirus disease 2019 (COVID-19) cases from the Huanan seafood market in Beijing, China, to define the minor variant genome populations from the start of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced pandemic.

14 Jun 2022

Study brings precision medicine closer to reality for diffuse large B cell lymphoma

DNA mutations are essential to the rapid development of an array of antibody-producing immune cells called B cells that collectively can recognize a vast number of specific targets.

25 May 2022

First draft genome sequence of the Monkeypox virus associated with major outbreak

In a recent study posted to the Virological discussion forum, researchers revealed a draft genome sequence of the monkeypox virus associated with a recent outbreak in Portugal.

23 May 2022

CDC study reveals hybrid SARS-CoV-2 spike from Delta/Omicron recombination event

The US Centers for Disease Control and Prevention (CDC) has conducted national-level genomic surveillance to identify and characterize delta-omicron recombinant genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A total of nine genomes with a hybrid delta-omicron spike protein have been identified.

14 May 2022

Discovery provides critical clues to why many immunotherapies trigger dangerous side effects

It's not often that a failed clinical trial leads to a scientific breakthrough. When patients in the UK started showing adverse side effects during a cancer immunotherapy trial, researchers at La Jolla Institute for Immunology (LJI) Center for Cancer Immunotherapy and University of Liverpool went back through the data and worked with patient samples to see what went wrong.

5 May 2022