Immune System News and Research

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Machine learning classifier reduces the time to identify personalized tumor reactive T cell receptors

Making a personalized T cell therapy for cancer patients currently takes at least six months; scientists at the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim have shown that the laborious first step of identifying tumor-reactive T cell receptors for patients can be replaced with a machine learning classifier that halves this time.

15 Mar 2024

UVA research could help identify COVID-19 survivors at risk for long-haul lung problems

UVA Health researchers have discovered a potential way to predict which patients with severe COVID-19 are likely to recover well and which are likely to suffer "long-haul" lung problems.

15 Mar 2024

DNA origami vaccine DoriVac paves way for personalized cancer immunotherapy

Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading.

15 Mar 2024

Study uncovers mutation impacting Alzheimer's progression

The scientist of the Faculty of Medicine of the University of Malaga José Luis Royo has coordinated a study that summarizes eight years of research and brings together 100 multidisciplinary specialists, identifying a mutation that alters Alzheimer's disease progression.

15 Mar 2024

New drug candidate designed at the atomic level could help halt emerging SARS-CoV-2 variants

Although COVID-19 has faded from the headlines, SARS-CoV-2 – the coronavirus behind the pandemic – is still rampantly infecting people around the world.

14 Mar 2024

Gut bacteria and tryptophan diet can play a protective role against pathogenic E. coli

Gut bacteria and a diet rich in the amino acid tryptophan can play a protective role against pathogenic E. coli, which can cause severe stomach upset, cramps, fever, intestinal bleeding and renal failure, according to a study published March 13 in Nature.

14 Mar 2024

Researchers identify T-cell subsets as effective therapeutic target for preventing transplant rejection

Houston Methodist researchers identified a troublesome subset of T-cells in transplant recipients that may be a more effective therapeutic target for preventing transplant rejection in patients.

14 Mar 2024

Innovative plasma-activated hydrogel dressings revolutionize chronic wound care

An effective treatment for chronic wounds that does not involve antibiotics, but an ionized gas to activate a wound dressing, has been developed by a team of international scientists.

13 Mar 2024

Novel CAR-T therapy shows promising results in glioblastoma patients

A collaborative project to bring the promise of cell therapy to patients with a deadly form of brain cancer has shown dramatic results among the first patients to receive the novel treatment.

13 Mar 2024

Scientists uncover an overlooked mechanism in the gut immune system of Crohn's disease patients

A team of scientists from DTU and other European universities have uncovered an overlooked mechanism in the gut immune system of patients suffering from severe cases of Crohn's disease.

13 Mar 2024

Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma

Targeting two brain tumor-associated proteins-;rather than one-;with CAR T cell therapy shows promise as a strategy for reducing solid tumor growth in patients with recurrent glioblastoma (GBM), an aggressive form of brain cancer, according to early results from the first six patients treated in an ongoing Phase I clinical trial led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

13 Mar 2024

Understanding how chikungunya virus affects the brain and body

The chikungunya virus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes and responsible for more than 900 deaths in Brazil since it arrived around ten years ago, is capable of spreading through the blood, reaching multiple organs and crossing the blood-brain barrier, which protects the central nervous system.

12 Mar 2024

NIH study uncovers vulnerable sites on Epstein-Barr virus protein

Studies of interactions between two lab-generated monoclonal antibodies (mAbs) and an essential Epstein-Barr virus (EBV) protein have uncovered targets that could be exploited in designing treatments and vaccines for this extremely common virus.

12 Mar 2024

Molecular Rosetta stone provides previously unknown insight into gut microbiome communication

Researchers from Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have uncovered thousands of previously unknown bile acids, a type of molecule used by our gut microbiome to communicate with the rest of the body.

12 Mar 2024

New “GPS nanoparticle” delivers a genetic punch to the protein implicated in tumor spread

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Immune System News and Research

Machine learning classifier reduces the time to identify personalized tumor reactive T cell receptors

UVA research could help identify COVID-19 survivors at risk for long-haul lung problems

DNA origami vaccine DoriVac paves way for personalized cancer immunotherapy

Study uncovers mutation impacting Alzheimer's progression

New drug candidate designed at the atomic level could help halt emerging SARS-CoV-2 variants

Gut bacteria and tryptophan diet can play a protective role against pathogenic E. coli

Researchers identify T-cell subsets as effective therapeutic target for preventing transplant rejection

Innovative plasma-activated hydrogel dressings revolutionize chronic wound care

Novel CAR-T therapy shows promising results in glioblastoma patients

Scientists uncover an overlooked mechanism in the gut immune system of Crohn's disease patients

Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma

Understanding how chikungunya virus affects the brain and body

NIH study uncovers vulnerable sites on Epstein-Barr virus protein

Molecular Rosetta stone provides previously unknown insight into gut microbiome communication

New “GPS nanoparticle” delivers a genetic punch to the protein implicated in tumor spread

LAG-3 protein structure may be the key to unlocking new cancer treatments

Study highlights potential therapeutic target for immune-related disorders

Researchers explore the role of vitamin A in pathogenesis of psychiatric disorders

Immune cells in the liver eat up excess cholesterol, study reveals

Researchers develop precise drugs to target HIV's Nef protein

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