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New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

Researchers described a novel antiviral mechanism of action for an FDA (food and drug administration)-approved thiopurine known as 6-thioguanine (6-TG).

21 Sep 2022

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

A new study published in the journal Reports focused on the hijacking of the pancreatic, endothelial, and gut GABA by SARS-CoV-2 and its associated pathology along with interventions.

10 Jun 2022

Scientists identify the role of phospholipid in maintaining epithelial cellular adhesion

Cells have certain proteins that help them adhere to each other while covering body surfaces and organs. Loss of these identifying proteins could result in cellular progression towards cancer and, subsequently, metastasis.

9 May 2022

Study reports thiopurines inhibit the replication of the betacoronaviruses HCoV-OC43 and SARS-CoV-2

Researchers demonstrated that the thiopurines block coronaviruses spike protein assembly and integration into progeny virions.

17 Mar 2022

Cannabidiol inhibits SARS-CoV-2 replication in human cells and mice

In research recently published in the journal of Science Advances, an interdisciplinary team of researchers from the University of Chicago assessed the potential role of cannabidiol (CBD), a natural product extracted from the cannabis plant, to prevent and inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in human cells and mice.

26 Jan 2022

Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

In a new study, researchers discuss the role of calcium signaling pathways as targets of inhibition in potential new antiviral therapeutic pathways for SARS-CoV-2.

20 Jan 2022

SARS-CoV-2 differs from other betacoronaviruses in a key IRE1α/XBP1 pathway

SARS-CoV-2 differs from other viruses in the beta coronavirus family in the activation of a key pathway associated with endoplasmic reticulum stress.

3 Jan 2022

Researchers use machine learning to shed light on genetic mutations linked with spina bifida

Weill Cornell Medicine researchers are using machine learning, a form of artificial intelligence, to shed light on genetic mutations associated with spina bifida.

20 Dec 2021

Novel technique solves structure of the HIV capsid alone and in complex with host factors

A new technique using electron tomography and subtomogram averaging at Diamond's electron Bio-Imaging Centre (eBIC), has solved the structure of the HIV capsid alone and in complex with host factors.

21 Nov 2021

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances a cellular stress response pathway that promotes survival of cancer cells, which become sensitive to pharmacological inhibition of this pathway. These findings were published online in Cancer Research, a journal of the American Association for Cancer Research, and point to a new therapeutic opportunity for this type of ovarian cancer for which new solutions are urgently needed.

22 Sep 2021

Neurokinin-1 receptor: a potential drug target for the treatment of COVID-19

An opinion article aims to provide evidence that SP could be the possible factor for initiating the cytokine storm during severe SARS-CoV-2 infection.

21 Sep 2021

Antibiotic clofoctol shows potential against SARS-CoV-2

In a recent study, a group of French researchers aimed to reduce the regulatory preclinical development steps that potential candidates are normally subjected to.

5 Jul 2021

New molecular pathway helps steer moving cells in specific directions

Working with fruit flies, scientists at Johns Hopkins Medicine say they have identified a new molecular pathway that helps steer moving cells in specific directions.

30 Mar 2021

Researchers report first spectroscopic imaging-based studies of neurological injury in COVID-19 patients

One of the first spectroscopic imaging-based studies of neurological injury in COVID-19 patients has been reported by researchers at Massachusetts General Hospital (MGH) in the American Journal of Neuroradiology.

19 Nov 2020

Thiopurines could help stop viral replication in human coronaviruses

Researchers from the Department of Microbiology & Immunology, Dalhousie University, University of Calgary, and Department of Biochemistry and Molecular Biology, University of British Columbia, Canada, worked with human coronaviruses in cell cultures to look for drugs that might prevent accumulation and replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Oct 2020

Inositol News and Research

New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

Scientists identify the role of phospholipid in maintaining epithelial cellular adhesion

Study reports thiopurines inhibit the replication of the betacoronaviruses HCoV-OC43 and SARS-CoV-2

Cannabidiol inhibits SARS-CoV-2 replication in human cells and mice

Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

SARS-CoV-2 differs from other betacoronaviruses in a key IRE1α/XBP1 pathway

Researchers use machine learning to shed light on genetic mutations linked with spina bifida

Novel technique solves structure of the HIV capsid alone and in complex with host factors

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Neurokinin-1 receptor: a potential drug target for the treatment of COVID-19

Antibiotic clofoctol shows potential against SARS-CoV-2

New molecular pathway helps steer moving cells in specific directions

Researchers report first spectroscopic imaging-based studies of neurological injury in COVID-19 patients

Thiopurines could help stop viral replication in human coronaviruses

Scientists identify cellular mechanism that shows promise in treating cancer

Novel strategy to stop tumors from developing new blood vessels

Yale discovery has implications for treatment of diabetes and non-alcoholic fatty liver disease

Researchers develop new substance to prevent vascular calcification

Astrocytes help the brain to establish long-lasting memories

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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