Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

Researchers find drug targets for treating metabolic syndrome

Ongoing studies by researchers at UT Southwestern Medical Center and other institutions have uncovered the biochemical basis of many of the factors contributing to what is known as the metabolic syndrome, suggesting potential new drug targets for treating the condition.

11 Aug 2005

High insulin levels increase inflammatory markers and beta-amyloids

Moderately elevated levels of insulin increase the levels of inflammatory markers and beta-amyloid in plasma and in cerebrospinal fluid, and these markers may contribute to Alzheimer's disease, according to a new study posted online today from Archives of Neurology, one of the JAMA/Archives journals.

9 Aug 2005

People with prehypertension are at much higher risk of heart attack

Normal blood pressure is lower than 120/80 millimeters of mercury (mm Hg). Prehypertension is systolic blood pressure between 120 and 139 and/or diastolic pressure between 80 and 89 mm Hg. (Systolic pressure is the force in the arteries when the heart beats and diastolic pressure is the force when the heart is at rest.) Hypertension is blood pressure 140/90 mm Hg or higher.

4 Aug 2005

Visceral obesity may be an important risk factor for insulin resistance syndrome in children

Waist circumference is associated with insulin resistance in children and may offer a simple way to identify children with risk factors for cardiovascular disease and type 2 diabetes, according to a study in the August issue of Archives of Pediatrics & Adolescent Medicine.

1 Aug 2005

Dairy foods may actually help dieters keep the muscle and lose even more fat

Most people don't realize when a person loses weight, they lose fat and muscle, but new research indicates dairy foods may actually help dieters keep the muscle and lose even more fat.

1 Aug 2005

Wealthy kids are not always healthy kids

An international team of researchers from the UK, Estonia, Denmark and Norway, have found that children from poorer families are not necessarily less healthy than those with more affluent and better educated parents.

23 Jul 2005

Wealth doesn't always equal health

Across Europe, children from poor families don't necessarily have worse health than children with more affluent and better educated parents, say researchers in this week's BMJ.

21 Jul 2005

New research finds molecular link between obesity and diabetes

Researchers say they have discovered a molecular link between obesity and type 2 diabetes, and the link could be a potential target for new drugs to treat the disease.

21 Jul 2005

Heart attack patients: shedding pounds reduces risks

Heart attack patients with diabetes or a cluster of cardiovascular risk factors known as metabolic syndrome have an increased risk of another heart attack, stroke or death, but patients who lost weight after their heart attacks were less likely to become diabetic, according to a new study in the July 19, 2005, issue of the Journal of the American College of Cardiology.

21 Jul 2005

Protein found in fat cells is a newly discovered cause of insulin resistance

A study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) has shown that a protein found in fat cells is a newly discovered cause of insulin resistance, establishing a previously unidentified molecular link between obesity and type 2 diabetes and offering a potential new target for the development of drugs to treat diabetes.

20 Jul 2005

Insulin resistance increases a person's risk for development of congestive heart failure

Congestive heart failure (CHF) is a major cause of illness and death, according to background information in the article. The death rate for patients with CHF is 4 to 8 times that of the general population. The predominant causes of heart failure are hypertension and coronary heart disease.

19 Jul 2005

Insulin keeps fat in the liver under control

Insulin, a hormone long recognized as a generator of fat, also keeps fat in the liver under control, according to a new study in the July issue of Cell Metabolism.

19 Jul 2005

Variant of a common protein plays a primary role in Type 2 diabetes and obesity

Scientists in France and the United States report that a variant of a common protein plays a primary role in Type 2 diabetes and obesity, key features of the "insulin resistance syndrome" that affects more than 50 million people in this country and a similar number in Europe.

19 Jul 2005

Scientists have identified a gene associated with both childhood and adult obesity

According to research published today in Nature Genetics, the team from Imperial College London, Hammersmith Hospital, London, and the CNRS Lille, France, have identified a gene (ENPP1), with strong links to childhood obesity in 3,147 in a sample of 4,886 French Caucasian individuals.

18 Jul 2005

Low dose birth control pill raises heart attack risk, especially in some women

A new review suggests that low-dose birth control pills, which are generally considered to be safer than the pill of the past, still carries an increased risk for heart attack and stroke.

11 Jul 2005

Fat adults more likely to have increased insulin resistance, a risk marker for Type 2 diabetes

Adult lifestyle has more influence on your chances of developing diabetes than childhood experience, according to new research whose findings contradict previously-held beliefs.

6 Jul 2005

Takeda Pharmaceuticals submits NDA for a new oral diabetes medication

Takeda Pharmaceuticals North America today announced that the company has submitted a New Drug Application (NDA) for a new oral medication that combines pioglitazone HCl and glimepiride, a sulfonylurea, to the United States Food and Drug Administration (FDA) for the treatment of type 2 diabetes.

30 Jun 2005

Major study says for diabetics with high blood pressure diuretics are the best option

A major new study has found that for people with type 2 diabetes and high blood pressure, cheaper diuretic medications may be the most cost-effective option in reducing hypertension.

29 Jun 2005

Exercise helps find genetic regions linked to prediabetes

People's bodies respond to exercise in different ways, and their genetic makeup is partly responsible.

28 Jun 2005

Insulin resistance drug with anti-inflammatory effects reduces risk factors

A drug, which reduces insulin resistance and also may have anti-inflammatory and other effects on blood vessels, lowered cardiovascular risk factors in patients with diabetes more than another diabetes medicine, even though both drugs improved blood sugar control equally, according to a new study (PDF) in the June 21, 2005, issue of the Journal of the American College of Cardiology.

21 Jun 2005