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Interleukin-6 (IL-6) is a protein that in humans is encoded by the "IL6" gene. IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation.
Competitive Intelligence Report on biosimilar and biosuperior therapeutic antibodies

Competitive Intelligence Report on biosimilar and biosuperior therapeutic antibodies

Research and Markets has announced the addition of the "Competitor Analysis: Biosimilar and Biosuperior Therapeutic Antibodies" report to their offering. [More]

Scientists identify factors that predict flu severity in patients

St. Jude Children's Research Hospital scientists have identified a signature immune response that might help doctors identify which newly diagnosed influenza patients are most likely to develop severe symptoms and suffer poor outcomes. The findings also help explain why infants and toddlers are at elevated risk for flu complications. The research appears in the upcoming issue of the American Journal of Respiratory and Critical Care Medicine. [More]
Low levels of pro-inflammatory cytokine in brain are important for cognition

Low levels of pro-inflammatory cytokine in brain are important for cognition

Although inflammation is frequently a cause of disease in the body, research from The University of Texas Health Science Center at San Antonio indicates that low levels of a pro-inflammatory cytokine in the brain are important for cognition. Cytokines are proteins produced by the immune system. [More]
Practicing yoga for atleast 3 months can reduce fatigue and inflammation in breast cancer survivors

Practicing yoga for atleast 3 months can reduce fatigue and inflammation in breast cancer survivors

Practicing yoga for as little as three months can reduce fatigue and lower inflammation in breast cancer survivors, according to new research. [More]
Study: Pro-inflammatory molecules linked with early death in HIV patients who abuse alcohol

Study: Pro-inflammatory molecules linked with early death in HIV patients who abuse alcohol

A study led by researchers at Boston University School of Medicine (BUSM) provides new insight into the impact that pro-inflammatory molecules have on early death in HIV patients who abuse alcohol. [More]
Takeda to acquire exclusive license to develop Natrogen's Natura-alpha compound

Takeda to acquire exclusive license to develop Natrogen's Natura-alpha compound

Takeda Pharmaceutical Company Limited and Natrogen Therapeutics International, Inc. jointly announced today an agreement whereby Takeda will acquire an exclusive license to develop Natrogen's Natura-alpha compound as well as an option to acquire Natrogen. Natura-alpha is a synthetic small molecule oral compound that is believed to inhibit pro-inflammatory cytokine expression, which may help to reduce gastrointestinal inflammation. Natura-alpha is currently in Phase 2 development for the treatment of ulcerative colitis. [More]
People with intermittent explosive disorder elevate levels of markers of systemic inflammation in blood

People with intermittent explosive disorder elevate levels of markers of systemic inflammation in blood

People with intermittent explosive disorder — a psychiatric illness characterized by impulsivity, hostility and recurrent aggressive outbursts — have elevated levels of two markers of systemic inflammation in their blood, according to a study involving nearly 200 subjects. [More]
Study: Immune cells outside the brain may regulate propensity to develop depression

Study: Immune cells outside the brain may regulate propensity to develop depression

A new study shows that immune cells outside the brain may regulate propensity to develop depression. The data were presented today at the American College of Neuropsychopharmacology Annual Meeting. [More]
Janssen reports positive pivotal Phase 2 study data of siltuximab for Multicentric Castleman's Disease

Janssen reports positive pivotal Phase 2 study data of siltuximab for Multicentric Castleman's Disease

Janssen Research & Development, LLC today announced positive results from a pivotal Phase 2 global registration study (MCD2001) suggesting siltuximab, an investigational compound, along with best supportive care, exhibited statistically significant efficacy and a tolerable safety profile compared with placebo and BSC in treating patients with the rare disorder Multicentric Castleman's Disease who are HIV-negative and human herpes virus 8-negative. [More]
Women under 50 more likely to experience mental stress-induced ischemia

Women under 50 more likely to experience mental stress-induced ischemia

Researchers have found that women younger than 50 with a recent heart attack are more likely to experience restricted blood flow to the heart (myocardial ischemia) in response to psychological stress. [More]
Children born to mothers with lupus have twice the risk of autism spectrum disorders

Children born to mothers with lupus have twice the risk of autism spectrum disorders

According to research presented this week at the American College of Rheumatology Annual Meeting in San Diego, children born to mothers with lupus may be at twice the risk of autism spectrum disorders than those born to mothers without the disease. [More]

FDA approves SC formulation of Genentech's Actemra for rheumatoid arthritis

Genentech, a member of the Roche Group, today announced that the U.S. Food and Drug Administration has approved a subcutaneous formulation of Actemra (tocilizumab) for the treatment of adults with moderately to severely active rheumatoid arthritis who have used one or more disease-modifying antirheumatic drugs, such as methotrexate, that did not provide enough relief. [More]

Prolactin hormone promotes liver growth, survival, and regeneration in rodents

​The hormone prolactin is probably best known for its role in stimulating milk production in mothers after giving birth. But prolactin also has an important function in the liver. This organ has the highest number of prolactin receptors in the body, ports that allow this hormone to enter liver cells. [More]

Recovery sleep over weekend may not reverse all effects of sleep lost during workweek

In many modern societies, adults often sacrifice sleep during the workweek to make time for other demands, then snooze longer on the weekends to recoup that lost sleep. Research has shown that even a few days of lost sleep can have adverse effects, including increased daytime sleepiness, worsened daytime performance, an increase in molecules that are a sign of inflammation in the body, and impaired blood sugar regulation. [More]
Study provides new insights into type 1 diabetes pathology

Study provides new insights into type 1 diabetes pathology

Joslin researchers have identified immune cells that promote growth of beta cells in type 1 diabetes. This study provides further evidence of a changed role for immune cells in type 1 diabetes pathology. The study appears online today and will also appear in the January issue of Diabetes. [More]

Ablynx Nets Another $33.7M From Merck Serono As Partnership Expands

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Ablynx Nets Another $33.7M From Merck Serono As Partnership Expands

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Exercise and diet led to less knee pain for adults with knee osteoarthritis

Exercise and diet led to less knee pain for adults with knee osteoarthritis

Among overweight and obese adults with knee osteoarthritis, combining intensive diet and exercise led to less knee pain and better function after 18 months than diet-alone and exercise-alone, according to a study in the September 25 issue of JAMA. [More]

Abbvie, Galapagos Ink Up To $405M CF Collaboration

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Abbvie, Galapagos Ink Up To $405M CF Collaboration

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