Irisin News and Research

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Irisin-based therapies may help combat Alzheimer’s disease

Researchers who previously developed the first 3D human cell culture models of Alzheimer's disease (AD) that displays two major hallmarks of the condition-;the generation of amyloid beta deposits followed by tau tangles-;have now used their model to investigate whether the exercise-induced muscle hormone irisin affects amyloid beta pathology.

8 Sep 2023

The role of exercise-induced hormone irisin in amyloid beta reduction

Researchers explored the biological mechanisms by which exercise-induced irisin attenuates amyloid-beta pathology in Alzheimer’s disease.

8 Sep 2023

Exploring the relationship between epigenetic aging and gut microbiome composition in physically fit men and women

Researchers investigate the relationship between the gut microbiome, physical fitness, and epigenetic aging in physically fit individuals.

14 Jul 2023

Revamping lifestyle can bolster brain health and stave off neurocognitive decline

In a recent article published in the journal Cureus, researchers at Loma Linda University Medical Center and the University of California Irvine reviewed the impact of applying the six pillars of lifestyle medicine — stress management, plant-based nutrition, avoidance of risky substances, physical activity, social connections, and restorative sleep — on neurocognitive decline and dementia.

14 Mar 2023

How does the brain change with age?

Researchers discussed cellular hallmarks of brain aging and therapeutic interventions to rejuvenate cognitive brain functions.

19 Jan 2023

ADDF-Harrington partnership accelerates the translation of innovative Alzheimer's research into therapies

The Alzheimer's Drug Discovery Foundation and Harrington Discovery Institute at University Hospitals in Cleveland have granted an ADDF-Harrington Scholar Award to Christiane Wrann, PhD, DVM, Associate Professor in Medicine at the Cardiovascular Research Center and the McCance Center for Brain Health at Massachusetts General Hospital and the Harvard Medical School in Boston.

12 Jan 2023

Exercise hormone irisin blocks Parkinson's-associated α-synuclein aggregation and related neuronal toxicity

A new paper discusses the hope held out by recent results on a compound called irisin, a short protein secreted by skeletal muscle that produces some exercise-related effects on the brain.

15 Sep 2022

Blocking FNDC5 prevents cancer-induced cachexia in mice

The severe muscle atrophy and weakness commonly associated with cancer growth (i.e., cachexia) can be prevented simply by being deprived of FNDC5, the precursor of the exercise hormone irisin, researchers from the Indiana University School of Medicine have found.

12 Sep 2022

Exercise hormone reduces protein levels linked to Parkinson's disease

Researchers from Johns Hopkins Medicine and the Dana Farber Cancer Institute in Boston have shown that a hormone secreted into the blood during endurance, or aerobic, exercise reduces levels of a protein linked to Parkinson's disease and halts movement problems in mice.

12 Sep 2022

The Alzheimer’s Association recognizes seven researchers for contributions to the field of dementia science

The Alzheimer’s Association will present seven awards at the Alzheimer’s Association International Conference 2022, recognizing researchers for their varied expertise, noteworthy achievements and innovative contributions to the field of Alzheimer’s and dementia science.

1 Aug 2022

Exercise hormone could have a therapeutic effect on COVID-19 patients

A study conducted by researchers at São Paulo State University suggests that irisin, a hormone secreted from muscles in response to exercise, could have a therapeutic effect on COVID-19 patients.

22 Sep 2020

CVIA publishes new issue that brings key research papers from top cardiologists

The journal Cardiovascular Innovations and Applications (CVIA) has just published a new issue, Volume 4 Issue 3 with an invitation to join the International Brugada Electrocardiographic Indices Registry.

1 Apr 2020

Alzheimer's disease protection from exercise hormone irisin

Irisin is found to be protective against Alzheimer’s disease finds a new study. The results of the new study were published in the journal Nature Medicine.

11 Feb 2019

Study reveals how exercise may protect against Alzheimer's disease

Athletes know a vigorous workout can release a flood of endorphins: "feel-good" hormones that boost mood. Now there's evidence that exercise produces another hormone that may improve memory and protect against Alzheimer's disease, according to a study co-led by Ottavio Arancio, MD, PhD, a researcher at Columbia University's Vagelos College of Physicians and Surgeons and Taub Institute for Research on Alzheimer's Disease and the Aging Brain.

11 Feb 2019

Exercise hormone can prevent Alzheimer's finds study

According to a large worldwide study, the hormone that is produced in the body during exercise called irisin, can prevent and delay the onset of mental faculty decline and Alzheimer’s disease. The results of the study were published in the latest issue of the journal Nature Medicine.

8 Jan 2019