Kawasaki Disease News and Research

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Kawasaki disease (also known as lymph node syndrome, mucocutaneous node disease, infantile polyarteritis and Kawasaki syndrome) is a disease, largely of infants, which affects many organs, including the skin, mucous membranes, lymph nodes, and blood vessel walls, but the most serious effect is on the heart where it can cause severe aneurysmal dilations.

Study uncovers blood clotting and immune protein pathways impacted in children with severe COVID-19

Researchers have discovered the blood clotting and immune protein pathways that are activated in severe cases of COVID-19 in children, paving the way for earlier diagnosis and more targeted treatments.

3 May 2022

Treg cell Notch receptors drive SARS-CoV-2-induced MIS-C

In a recent study under consideration at Nature Portfolio Journal and posted to the Research Square* preprint server, researchers demonstrated the evolution of multi-system inflammatory syndrome in children (MIS-C) following acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

12 Apr 2022

Heart complications uncommon for children and young adults after SARS-CoV-2 infection

Heart complications are uncommon, yet treatable for children and young adults after COVID-19 disease or SARS-CoV-2 infection, according to a new scientific statement from the American Heart Association that details what has been learned about how to treat, manage and even prevent cardiovascular complications from the SARS-CoV-2 virus in youth.

12 Apr 2022

Is SARS-CoV-2 a Superantigen?

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), scientists have been conducting extensive studies to understand various aspects of the virus. Researchers have stated that SARS-CoV-2 manifests several biological and clinical consequences of a superantigen

29 Mar 2022

Innate immune processes involved in SARS-CoV-2 recognition and resultant inflammation

A new article reviewed the innate immune detection and signaling pathways that the host uses against SARS-CoV-2.

7 Feb 2022

Research finds quick recovery of heart function in children with COVID-19-related MIS-C

Heart function recovery returned within three months in children who developed COVID-19-related multisystem inflammatory syndrome (MIS-C), according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

19 Jan 2022

Study predicts incidence rates of adverse outcomes of COVID-19 vaccination

In a new study, a team of researchers estimated the pre-pandemic incidence rates of adverse events of special interest now observed in association with COVID-19 vaccines in Canada.

18 Jan 2022

Multisystem inflammatory syndrome in children rare after COVID-19 vaccination in adolescents

The current study was based on merged results using the CDD’s surveillance database coupled with the Vaccine Adverse Event Reporting System (VAERS), along with reports from health departments or physicians to the CDC.

7 Jan 2022

The autoantibody profile in COVID-19 patients with MIS-C

A new study assessed the presence of autoantibodies against autoantigens associated with known autoimmune diseases in patients with COVID-19.

10 Nov 2021

Studies test intravenous immunoglobulin for treatment of Kawasaki disease and MIS-C

Kawasaki disease (KD) is rare, with fewer than 6,000 diagnosed cases per year in the United States. It is most common in infants and young children and causes inflammation in the walls of some blood vessels in the body.

27 Oct 2021

Scientists search for cause of mysterious covid-related inflammation in children

Like most other kids with covid, Dante and Michael DeMaino seemed to have no serious symptoms.

20 Oct 2021

Common treatment for MIS-C patients likely works by depleting neutrophils

Intravenous immune globulin (IVIG) — a common treatment for multisystem inflammatory syndrome in children (MIS-C) — likely works by depleting immune cells called neutrophils, according to a recent study funded by the National Institutes of Health.

15 Oct 2021

Formal health care transition programs needed to provide uninterrupted support for youth with Kawasaki disease

Kawasaki disease is the most common cause of acquired heart disease that develops in early childhood, creating inflammation in blood vessels, particularly heart arteries.

11 Oct 2021

Study aims to find ways of identifying children at risk for severe COVID-19

An ongoing study is looking at the relationship between cytokines in saliva and COVID-19 infection to help predict the severity of infection.

8 Oct 2021

Abnormal T cell responses to COVID-19 do not appear to be the cause of MIS-C in children

Multisystem inflammatory syndrome in children (MIS-C) is a serious condition associated with a recent COVID-19 infection.

7 Oct 2021

Dual therapy improves cardiac outcomes in pediatric patients suffering from MIS-C

A recent study by a multidisciplinary team of cardiologists and infectious disease specialists at Children's Hospital Colorado (Children's Colorado) found that pediatric patients suffering from Multisystem Inflammatory Syndrome (MIS-C) who received initial, intensified therapy consisting of intravenous immunoglobulin (IVIG) plus Infliximab had improved cardiac outcomes versus those who received IVIG alone.

30 Sep 2021

Kawasaki Disease News and Research

Further Reading

Study uncovers blood clotting and immune protein pathways impacted in children with severe COVID-19

Treg cell Notch receptors drive SARS-CoV-2-induced MIS-C

Heart complications uncommon for children and young adults after SARS-CoV-2 infection

Is SARS-CoV-2 a Superantigen?

Innate immune processes involved in SARS-CoV-2 recognition and resultant inflammation

Research finds quick recovery of heart function in children with COVID-19-related MIS-C

Study predicts incidence rates of adverse outcomes of COVID-19 vaccination

Multisystem inflammatory syndrome in children rare after COVID-19 vaccination in adolescents

The autoantibody profile in COVID-19 patients with MIS-C

Studies test intravenous immunoglobulin for treatment of Kawasaki disease and MIS-C

Scientists search for cause of mysterious covid-related inflammation in children

Common treatment for MIS-C patients likely works by depleting neutrophils

Formal health care transition programs needed to provide uninterrupted support for youth with Kawasaki disease

Study aims to find ways of identifying children at risk for severe COVID-19

Abnormal T cell responses to COVID-19 do not appear to be the cause of MIS-C in children

Dual therapy improves cardiac outcomes in pediatric patients suffering from MIS-C

Kawasaki Disease presents a growing threat to UK children’s heart health

Long-term effects of COVID-19 in children

Researchers identify biomarkers for rare, serious complication in children with COVID-19

Three new guidelines released for treatment and management of systemic vasculitis

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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