Kidney Transplant News and Research

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A kidney transplant is an operation where a healthy kidney from one person (the donor) is transferred to a person who has little or no kidney function (the recipient).

Retransplantation may provide better survival over dialysis after failed first kidney transplant

Kidney transplantation is the preferred therapy after kidney failure, but kidneys transplanted from deceased donors often do not last for the rest of a recipient's life.

28 Dec 2021

Vaccinated kidney transplant recipients not adequately protected against emerging SARS-CoV-2 variants

Kidney transplant recipients tend to mount impaired antibody responses against emerging SARS-CoV-2 variants after standard two-dose COVID-19 vaccination, according to new research published in CJASN.

23 Dec 2021

Booster shots improve CD8+ T cell response to SARS-CoV-2 in animal model

In a new study, published on the bioRxiv* preprint server, scientists showed in a mice model that three doses of the same synthetic peptide vaccine, eliciting an exclusive CD8+ T cell response against one SARS-CoV-2 Spike epitope, protected against lethal SARS-CoV-2 infection, in the absence of neutralizing antibodies. Researchers also showed that the third dose resulted in superior generation of effector-memory T cells in the circulation and tissue-resident memory T (TRM) cells.

20 Dec 2021

NYU Langone Health performs second successful investigational xenotransplantation procedure

Less than two months after the first breakthrough surgery, NYU Langone Health has performed its second successful investigational xenotransplantation procedure using a genetically engineered pig kidney.

13 Dec 2021

Fourth shot of Moderna COVID vaccine improves Delta variant neutralization in kidney transplant patients

New research suggests that a fourth dose of the mRNA-1273 vaccine in kidney transplant recipients improves Delta variant serum neutralization.

1 Dec 2021

UK's leading health charities team up to encourage vulnerable people to get COVID-19 vaccines

Some of the UK's leading health charities including the British Heart Foundation, Diabetes UK and Cancer Research UK are joining forces with the government and the NHS to encourage vulnerable people to get their COVID-19 vaccines.

25 Nov 2021

Emergence of SARS-CoV-2 immune escape variants in an immunocompromised patient

A German case study recently published in the journal Nature Communications has characterized a long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection dynamics in an immunosuppressed kidney transplant recipient and provided evidence for the evolution of SARS-CoV-2 into potentially harmful immune escape mutants during persistent infections.

10 Nov 2021

SARS-CoV-2 infection amplifies immune system–related differences in dialysis, kidney transplant patients

People with kidney failure who are on dialysis or who have received a kidney transplant face a higher risk of dying from COVID-19.

7 Nov 2021

Effectiveness of mRNA BNT162b2 COVID-19 vaccine in immunocompromised individuals

Israeli researchers evaluate the antibody response in ICPs to assess antibody-mediated immunity following vaccination with the Pfizer-BioNTech vaccine.

26 Oct 2021

First investigational xenotransplantation marks a major step towards adequate organ supply

The first investigational transplant of a genetically engineered, nonhuman kidney to a human body was recently completed at NYU Langone Health—marking a major step forward in potentially utilizing an alternative supply of organs for people facing life-threatening disease.

21 Oct 2021

New protocol reduces hospitalizations, deaths of liver and kidney transplant patients with COVID-19

Liver and kidney transplant recipients have a higher risk of severe COVID-19 and/or death should they become infected because the medication they take to ensure a successful transplant suppresses their immune systems.

15 Oct 2021

Kidney transplant patients are more susceptible to harmless bacterium, finds study

It's a pervasive bacterium found in soil and water that rarely causes disease, but a new national review of nocardia infection in people who have had a kidney transplant shows that when it occurs it most commonly causes pneumonia and brain abscess, and reminds their physicians to stay on the lookout for it, investigators say

11 Oct 2021

Organ centers to transplant patients: Get a covid shot or move down on waitlist

A Colorado kidney transplant candidate who was bumped to inactive status for failing to get a covid-19 vaccine has become the most public example of an argument roiling the nation's more than 250 organ transplant centers.

8 Oct 2021

Cesarean birth may not be the safest mode of delivery for transplant patients

New research suggests that cesarean births for transplant patients carry higher risks to baby and mother.

5 Oct 2021

Anti-CD20 therapy patients can develop immune responses after SARS-CoV-2 vaccination

A new systematic review and meta-analysis focused on the humoral and cell-mediated immune responses after COVID-19 vaccination in patients undergoing anti-CD20 antibodies treatment.

5 Oct 2021

Study provides insights on kidney transplant recipients’ immune response to SARS-CoV-2 infection

New research provides insights on the immune responses of kidney transplant recipients following infection with the virus that causes COVID-19. The study, which is published in JASN, may help explain why these individuals face a higher risk of dying from COVID-19 than others in the general population.

4 Oct 2021

Immunocompromised patients show decreased response to SARS-CoV-2 mRNA vaccines

Researchers explore the germinal cell responses in both healthy individuals and kidney transplant patients in their recent study.

29 Sep 2021

Study investigates the mechanism underlying kidney damage in COVID-19 patients

A review article published in the journal Frontiers in Physiology by researchers affiliated with the Federal University of São Paulo in Brazil discusses the mechanisms whereby SARS-CoV-2 damages the kidneys, potentially serving as a basis for further research in pursuit of treatments to prevent severe renal problems and even chronic kidney disease in COVID-19 patients.

29 Sep 2021

Study reports on ex vivo drug delivery system for delivering MSCs to kidney disease patients

Scientists are reporting promising results in the early stages of a clinical trial designed to gauge the feasibility of a new type of treatment for people with acute kidney disease.

28 Sep 2021

Study suggests two doses of COVID-19 vaccine may offer some protection for kidney transplant patients

Researchers from Toronto, Canada, performed a cohort study to analyze the impact of COVID-19 vaccination on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and clinical outcomes in kidney transplant patients. This study is available on the preprint server, medRxiv.

27 Sep 2021