Leukopenia News and Research

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Leukopenia is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection.

Letermovir: A promising breakthrough in CMV prevention for kidney transplant recipients

In a recent article published in the journal JAMA Network, researchers performed a randomized clinical trial (RCT) to demonstrate the noninferiority of letermovir vs. valganciclovir for prophylaxis of cytomegalovirus (CMV) in adult CMV-seronegative kidney transplant recipients (KTRs) who received a kidney from a CMV-seropositive individual.

13 Jun 2023

The safety and tolerability of Remdesivir in children affected by COVID-19

Researchers reported findings of a multicenter study conducted across ten hospitals in Italy to investigate the safety of RDV in children affected by COVID-19.

2 Feb 2023

Novel T cell receptor therapy shows early promise for treating solid tumors

Afamitresgene autoleucel (afami-cel; formerly ADP-A2M4), an adoptive T cell receptor (TCR) therapy targeting the MAGE-A4 cancer antigen, achieved clinically significant results for patients with multiple solid tumor types in a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

9 Jan 2023

Novel zoonotic Langya virus identified in China

Scientists discuss their discovery of the novel Langya henipavirus in eastern China.

11 Aug 2022

Exploring hematological alterations in COVID-19 patients

New study findings indicated that some hematological alterations that occur during COVID-19-related hospital admission were associated with an increase in the risk of COVID-19-associated ICU admission and mortality.

26 Jan 2022

Urinary SARS-CoV-2 RNA is a prognosticator of COVID-19

A new study published in the journal Diagnostics was based on the hypothesis that detecting urinary SARS-CoV-2 nucleic acid––which may result in renal and cardiovascular endothelial destruction to facilitate viral access to the kidney parenchyma—may be used as a specific biomarker to indicate the severity of COVID-19.

16 Nov 2021

Study links barotrauma to COVID-19 in younger patients

To better understand the possible relationship between severe infection and poor in-hospital outcomes, researchers from the Internal Medicine, and the Pulmonary Critical Care Medicine, Rutgers University, Newark, USA, presented a case series linking barotrauma to COVID-19 in younger patients.

28 May 2021

Adoptive T-cell therapy targeting MAGE-A4 achieves responses in patients with multiple solid tumors

The adoptive T-cell therapy ADP-A2M4, which is engineered to express a T-cell receptor (TCR) directed against the MAGE-A4 cancer antigen, achieved responses in patients with multiple solid tumor types, including synovial sarcoma, head and neck cancer and lung cancer, according to results from a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

29 May 2020

Factor responsible for formation of white blood cells has regulatory effect on adaptive immunity

Granulocyte colony-stimulating factor, which causes division and differentiation of bone marrow cells depending on the body's need for leukocytes, has a significant regulatory effect not only on innate, but also on adaptive immunity.

31 Oct 2019

$FDA grants accelerated approval to new treatment for refractory multiple myeloma$

FDA grants accelerated approval to new treatment for refractory multiple myeloma

Today, the U.S. Food and Drug Administration granted accelerated approval to Xpovio (selinexor) tablets in combination with the corticosteroid dexamethasone for the treatment of adult patients with relapsed refractory multiple myeloma who have received at least four prior therapies and whose disease is resistant to several other forms of treatment, including at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody.

3 Jul 2019

Researchers use genetically manipulated virus to combat prostate cancer

Researchers at the São Paulo State Cancer Institute in Brazil have succeeded in using a genetically manipulated virus to destroy tumor cells upon injection into mice with prostate cancer.

27 Jun 2019

FDA extends indication of metastatic breast cancer treatment to include male patients

The U.S. Food and Drug Administration today is extending the indication of Ibrance (palbociclib) capsules in combination with specific endocrine therapies for hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer in male patients.

5 Apr 2019

Study reveals safety, efficacy of brexpiprazole for schizophrenia patients with severe psychotic symptoms

Otsuka Pharmaceutical Co., Ltd. and H. Lundbeck A/S announced study results on the safety and efficacy of brexpiprazole in the treatment of patients with schizophrenia experiencing severe psychotic symptoms during an acute episode. The data will be presented at the upcoming Psych Congress, held in Orlando from October 25-28, 2018.

26 Oct 2018

Pfizer announces PALOMA-3 trial results in patients with HR+, HER2- metastatic breast cancer

Pfizer Inc. today announced detailed overall survival data from the PALOMA-3 trial, which evaluated IBRANCE (palbociclib) in combination with fulvestrant compared to placebo plus fulvestrant in women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer whose disease progressed on or after prior endocrine therapy.

22 Oct 2018

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

AstraZeneca and Merck & Co., Inc., Kenilworth, N.J., today announced detailed results from the Phase III SOLO-1 trial testing LYNPARZA (olaparib) 300 mg tablets twice-daily as a maintenance treatment for patients with newly diagnosed advanced BRCA-mutated ovarian cancer who were in complete or partial response following 1st-line standard platinum-based chemotherapy.

22 Oct 2018

FDA accepts Bristol-Myers Squibb’s application for Sprycel for treating pediatric leukemia

Bristol-Myers Squibb Company today announced that the U.S. Food and Drug Administration accepted its supplemental Biologics License Application for Sprycel (dasatinib) in combination with chemotherapy for the treatment of pediatric patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia.

30 Aug 2018

FDA grants approval for first breast cancer drug through 'Real-Time Oncology Review'

The U.S. Food and Drug Administration today approved Kisqali (ribociclib) in combination with an aromatase inhibitor for the treatment of pre/perimenopausal or postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer, as initial endocrine-based therapy.

19 Jul 2018

Scoring system based on PIRO helps predict mortality in surgical ICU patients with severe sepsis

A new classification system that scores the variables associated with mortality rates for patients who develop intra-abdominal sepsis after surgery may help guide care and improve outcomes

2 Jul 2018

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

AstraZeneca and Merck, known as MSD outside the United States and Canada, today announced that Japan's Pharmaceuticals and Medical Devices Agency has approved LYNPARZA tablets for use in patients with unresectable or recurrent BRCA-mutated, human epidermal growth factor receptor 2 -negative breast cancer who have received prior chemotherapy.

2 Jul 2018

Simple DNA test can predict risk of bad side effects to thiopurine drugs

Screening a tiny section of DNA could help East Asian patients avoid severe reactions to some medications.

2 Jul 2018

Leukopenia News and Research

Further Reading

Letermovir: A promising breakthrough in CMV prevention for kidney transplant recipients

The safety and tolerability of Remdesivir in children affected by COVID-19

Novel T cell receptor therapy shows early promise for treating solid tumors

Novel zoonotic Langya virus identified in China

Exploring hematological alterations in COVID-19 patients

Urinary SARS-CoV-2 RNA is a prognosticator of COVID-19

Study links barotrauma to COVID-19 in younger patients

Adoptive T-cell therapy targeting MAGE-A4 achieves responses in patients with multiple solid tumors

Factor responsible for formation of white blood cells has regulatory effect on adaptive immunity

FDA grants accelerated approval to new treatment for refractory multiple myeloma

Researchers use genetically manipulated virus to combat prostate cancer

FDA extends indication of metastatic breast cancer treatment to include male patients

Study reveals safety, efficacy of brexpiprazole for schizophrenia patients with severe psychotic symptoms

Pfizer announces PALOMA-3 trial results in patients with HR+, HER2- metastatic breast cancer

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

FDA accepts Bristol-Myers Squibb’s application for Sprycel for treating pediatric leukemia

FDA grants approval for first breast cancer drug through 'Real-Time Oncology Review'

Scoring system based on PIRO helps predict mortality in surgical ICU patients with severe sepsis

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

Simple DNA test can predict risk of bad side effects to thiopurine drugs

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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