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Monoclonal antibody Prasinezumab shows promise in slowing rapid Parkinson's progression

A recent study in Nature Medicine evaluated the efficacy of prasinezumab, a monoclonal antibody, in slowing the progression of motor symptoms in Parkinson’s disease patients with rapidly progressing forms, using phase II clinical trial data.

19 Apr 2024

Gut microbiome shows no clear link to cognitive impairments in Parkinson's disease

Study investigates the gut microbiome's role in Parkinson's disease patients with mild cognitive impairments, revealing no distinct microbiome signatures associated with MCI in PD compared to cognitively normal PD patients or controls.

8 Apr 2024

New study reveals key differences in Parkinson’s disease progression using real-world data

The differences in the progression of Parkinson’s disease (PD) between real-world and research populations.

18 Mar 2024

Innovative levodopa infusion pump trial shows promise for reducing Parkinson's symptoms

An international, multisite phase 3 trial co-led by a University of Cincinnati researcher found Parkinson's disease medication delivered through an infusion pump is safe and effective at reducing symptoms for longer periods of time.

15 Mar 2024

Study reveals pivotal insights into the progression of Parkinson's disease

Parkinson's disease, the second most common type of progressive dementia after Alzheimer's disease, affects nearly 1 million people in the U.S. and an estimated 10 million individuals worldwide.

24 Feb 2024

Deep brain stimulation may improve quality of life in Parkinsons disease

Researchers compare the impact of medication alone or deep brain stimulation of the subthalamic nuclei in quality of life in Parkinson's patients.

22 Jan 2024

Risk factors for the development of freezing of gait in Parkinson’s disease patients

The risk factors that influence the development of freezing of gait or FOG.

6 Dec 2023

New gene therapy strategy shows promise for Parkinson's disease

Researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences (CAS) and their collaborators have developed a gene therapy strategy to selectively manipulate Parkinson's disease-affected circuitry and attenuate the core motor symptoms of Parkinson's disease in rodent and nonhuman primate animals.

2 Nov 2023

Groundbreaking study reveals most effective adjunctive drug for Parkinson's disease

The efficacy, tolerability, and safety of various anti-Parkinson's drugs.

23 Oct 2023

CRISPR/sgRNA-SAM therapy: a potential breakthrough for Parkinson's disease?

Researchers utilize the CRISPR-Cas9 system to induce the synthesis of dopamine (DA) in the brains of a rat model for Parkinson’s disease.

11 Aug 2023

Digital technologies for effective geriatric care: successes, challenges and future perspectives

Researchers discussed the current achievements, challenges, and potential opportunities in using digital technologies.

21 Jul 2023

Multiple discoveries open new paths for early prediction of Parkinson's disease trajectories

Hand tremors and slowed movements are two of the most widely recognized hallmarks of Parkinson's disease, and for many sufferers the first indication that something is amiss.

6 Jul 2023

What role does dysbiosis play in Parkinson's disease?

The current study, published in the journal Revue Neurologique, is based on the hypothesis that dysbiosis, or unhealthy variations in the gut and oral microbiota, is a key component of PD pathogenesis.

19 Mar 2023

Exploring the neuroprotective potential of cell-penetrating peptides, extracellular vesicles, and micro ribonucleic acids

In a recent review published in Biomedicines, researchers explored extracellular vesicles (EVs), cell-penetrating peptides (CPPs), and micro ribonucleic acids (miRNAs) as therapies for neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).

1 Mar 2023

Researchers report on a genome-wide reconstruction of human microbes to develop personalized therapies

Researchers reported on AGORA2, an expansion of their previously published resource, AGORA, of genomewide metabolic reconstructions of human intestinal microbes.

26 Jan 2023

The currently available evidence on viral-induced parkinsonism

A new review attempts to summarize all known about the relationship between viral illness and parkinsonian disorders to facilitate further research.

31 Aug 2022

Research suggests a new pathway for developing Parkinson's disease

There is currently no cure for Parkinson's disease (PD), and one of the main difficulties for developing treatments is that we don't know exactly how or why the disease occurs.

4 Jul 2022

Study uncovers a promising drug candidate to minimize dyskinesia in Parkinson's patients

A new study from Texas Biomedical Research Institute (Texas Biomed) and collaborators has identified a promising drug candidate to minimize uncontrolled, erratic muscle movements, called dyskinesia, associated with Parkinson's disease.

1 Dec 2021

Northwestern scientists receive awards totaling nearly $18 million for Parkinson's disease research

Northwestern University scientists have received two awards totaling nearly $18 million for Parkinson's disease research from The ASAP Collaborative Research Network, a program of the Aligning Science Across Parkinson's (ASAP) initiative being implemented through The Michael J. Fox Foundation.

27 Oct 2021

Using deep brain stimulation to treat Parkinson’s Disease

News-Medical spoke to Dr. Aryn Gittis about her latest research into Parkinson's disease and how deep brain stimulation could be used to help treat it.