Lipoprotein News and Research

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A lipoprotein is a biochemical assembly that contains both proteins and lipids. The lipids or their derivatives may be covalently or non-covalently bound to the proteins.

Intravenous infusion of HDL cholesterol could reduce risk of subsequent heart attack

An intravenous infusion of good cholesterol could reduce the risk of a subsequent heart attack, researchers reported at the American Heart Association's Scientific Sessions 2012.

6 Nov 2012

Data from four Phase 2 trials of AMG 145 to be presented at AHA Scientific Sessions 2012

Amgen will present data from four Phase 2 trials of AMG 145, an investigational fully human monoclonal antibody directed against PCSK9, a protein that reduces the liver's ability to remove low density lipoprotein cholesterol, or "bad" cholesterol from the blood, at the upcoming American Heart Association Scientific Sessions 2012.

3 Nov 2012

Resistin protein causes high levels of bad cholesterol

Canadian scientists have discovered that a protein called resistin, secreted by fat tissue, causes high levels of "bad" cholesterol (low-density lipoprotein or LDL), increasing the risk of heart disease.

29 Oct 2012

Lifting weights may play a role in reducing risk of metabolic syndrome

People who lift weights are less likely to have metabolic syndrome—a cluster of risk factors linked to heart disease and diabetes, reports a study in the October issue of The Journal of Strength and Conditioning Research, official research journal of the National Strength and Conditioning Association (NSCA).

25 Oct 2012

Cardiovascular disease risk varies with HIV subgroup

The ability of lipids to predict risk for cardiovascular disease may be weakened in women who are infected with HIV, report researchers.

23 Oct 2012

Study finds overall decline in cholesterol levels among U.S. adults

An analysis of nationally-representative data indicates that between 1988 and 2010 there has been a trend of declining average levels of total cholesterol, non-high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol for U.S. adults overall, according to a study in the October 17 issue of JAMA.

17 Oct 2012

Resverlogix commences RVX-208 Phase 2 trial in pre-diabetes mellitus

Resverlogix Corp. today announced that it has initiated an exploratory Phase 2 clinical trial in patients with pre-diabetes mellitus to examine the effects of RVX-208 and ApoA-I production on glucose metabolism.

17 Oct 2012

Poor sleep shows cardiovascular links in adolescents

Sleep disturbance in healthy adolescents is associated with an increased risk for cardiovascular disease in later life, research suggests.

11 Oct 2012

GW researcher to help HIV patients better understand treatments for cardiovascular issues

In 1980, men and women who were diagnosed with the human immunodeficiency virus (HIV) had little to no hope of living long, full lives. Thanks to advances in science and medicine, this is no longer the case. HIV patients now live a near-normal lifespan. However, as patients live longer, new medical issues arise.

3 Oct 2012

Eating apples might help keep the cardiologist away

Eating an apple a day might in fact help keep the cardiologist away, new research suggests.

3 Oct 2012

HDL may protect against abdominal aortic aneurysm

High levels of high-density lipoprotein cholesterol inhibit the formation of abdominal aortic aneurysm, findings from experimental mouse models suggest.

2 Oct 2012

Oil blend plus antihypertensive lowers blood pressure, cholesterol level

A blend of sesame and rice bran oil could reduce blood pressure by almost as much as an antihypertensive medication, say researchers.

1 Oct 2012

Cholesterol has repercussions for recovering heroin addicts

Cholesterol levels may be negatively associated with heroin craving in patients on methadone maintenance therapy, researchers suggest.

1 Oct 2012

ApoA-V as a contributor to dyslipidemia in obese children

Insulin may be an important regulator of serum apolipoprotein A-V levels in obese people and may contribute to the development of obesity-associated dyslipidemia, say Japanese researchers.

27 Sep 2012

Enrollment complete in Resverlogix‘s RVX-208 Phase 2b trial on cardiovascular disease

Resverlogix Corp. today announced that it has completed enrollment in ASSURE, a Phase 2b clinical trial targeting high-risk cardiovascular disease patients.

27 Sep 2012

High uric acid precursor of obesity, metabolic syndrome

The relationship between uric acid and early cardiometabolic risk may precede obesity and the metabolic syndrome, show study findings.

20 Sep 2012

Pfizer announces that 14 abstracts for tofacitinib to be presented at ACR/ARHP annual meeting

Pfizer Inc. announced today that 14 abstracts for tofacitinib, an investigational oral Janus kinase (JAK) inhibitor for the treatment of adults with moderate-to-severe active rheumatoid arthritis (RA), will be presented at the American College of Rheumatology (ACR) / Association of Rheumatology Health Professionals (ARHP) 2012 Annual Meeting, which is being held November 9-14 in Washington, D.C.

18 Sep 2012

Type 2 diabetes mellitus patients are at increased risk for cardiovascular disease

LipoScience, Inc., a highly innovative diagnostic company that is advancing patient care by developing high value proprietary blood tests using nuclear magnetic resonance technology, today announced the publication of results from a clinical study in the American Journal of Cardiology suggesting that despite having cholesterol levels considered acceptable by today's clinical standards, patients with Type 2 diabetes mellitus (T2DM) are at increased risk for cardiovascular disease-related events.

17 Sep 2012

Pam2Cys nasal spray may be useful agent against pandemics and emerging viral strains

In an advance toward development of a nasal spray that protects against infection with influenza and spread of the disease, scientists are reporting identification of a substance that activates the first-line defense system against infection inside the nose. They describe effects of a synthetic form of a natural substance found in bacterial cell walls in ACS' journal Molecular Pharmaceutics.

13 Sep 2012