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Epigenetic changes drive successful metastases of pancreatic cancer cells

Epigenetic changes drive successful metastases of pancreatic cancer cells

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells. [More]
Accurate test for jaundice could lead to effective treatment in premature newborns

Accurate test for jaundice could lead to effective treatment in premature newborns

Seeking to improve the care of preterm infants, a new study by researchers at Rutgers Robert Wood Johnson Medical School has found a more accurate test for jaundice, a common disorder in newborns. [More]
Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Metastatic pancreatic cancer -- cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths -- changes its metabolism and is "reprogrammed" for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics. [More]
Novel treatment can effectively inhibit development of GVHD in mice, study shows

Novel treatment can effectively inhibit development of GVHD in mice, study shows

Graft-versus-host-disease (GVHD) is the leading cause of non-relapse associated death in patients who receive stem cell transplants. [More]
Childhood obesity starts in the womb?

Childhood obesity starts in the womb?

There is incontrovertible evidence that some harmful drugs and toxins can affect lifelong health. For example, if women take certain drugs in pregnancy, such as thalidomide, there are well documented effects on lifelong health. These have obvious and dramatic effects on the child... [More]
Antioxidant may prevent development of NAFLD in offspring of obese mothers

Antioxidant may prevent development of NAFLD in offspring of obese mothers

In new research published online in The FASEB Journal, scientists show that the antioxidant pyrroloquinoline quinone may prevent the development of nonalcoholic fatty liver disease in offspring. [More]
Epigenetic changes favor development of fatty liver in humans and mice

Epigenetic changes favor development of fatty liver in humans and mice

Mice with a strong tendency to obesity already exhibit epigenetic changes at six weeks of age, inducing the liver to amplify its production of the enzyme DPP4 and release it into the circulation. Over the long term, this favors the development of a fatty liver. [More]
New report reveals 25% drop in overall cancer death rate in the U.S.

New report reveals 25% drop in overall cancer death rate in the U.S.

A steady decline over more than two decades has resulted in a 25% drop in the overall cancer death rate in the United States. The drop equates to 2.1 million fewer cancer deaths between 1991 and 2014. [More]
Natural antioxidant can protect offspring of obese mice from NAFLD, study shows

Natural antioxidant can protect offspring of obese mice from NAFLD, study shows

A common antioxidant found in human breast milk and foods like kiwi fruit can protect against nonalcoholic fatty liver disease in the offspring of obese mice, according to researchers at the University of Colorado Anschutz Medical Campus. [More]
First interactive 3D video hologram displays live footage of internal organs

First interactive 3D video hologram displays live footage of internal organs

UK scientists are developing an interactive holographic video created from an MRI or CT scan that can display live footage of internal organs in front of a user where features can be rotated, enlarged, and isolated, delivering a breakthrough in medical imaging and education. [More]
200th live donor kidney transplant offers promise of new life for the New Year

200th live donor kidney transplant offers promise of new life for the New Year

In late December in San Antonio, Texas, a 36-year-old mother of three from Jefferson City, Missouri, gave her best friend the most precious gift of all: a healthy kidney and the promise of a new life for the New Year. [More]
AAV-based gene therapy to treat liver disorders advances into human testing

AAV-based gene therapy to treat liver disorders advances into human testing

Liver-directed gene therapy delivered using adeno-associated viral (AAV) vectors to treat diseases such as hemophilia have advanced into human testing. [More]
Researchers warn about taking psilocybin-containing ‘magic mushrooms’

Researchers warn about taking psilocybin-containing ‘magic mushrooms’

In a survey of almost 2,000 people who said they had had a past negative experience when taking psilocybin-containing "magic mushrooms," Johns Hopkins researchers say that more than 10 percent believed their worst "bad trip" had put themselves or others in harm's way, and a substantial majority called their most distressing episode one of the top 10 biggest challenges of their lives. [More]
Children's Hospital Los Angeles performs 300th pediatric liver transplant

Children's Hospital Los Angeles performs 300th pediatric liver transplant

At 7 months old, Donovan Daniels of Westminster may not understand for some time just how serious his medical condition, biliary atresia, really is. [More]
Fred Hutch’s new Evergreen Fund to promote commercialization of research into lifesaving therapies

Fred Hutch’s new Evergreen Fund to promote commercialization of research into lifesaving therapies

Fred Hutchinson Cancer Research Center announced its first-ever grants from its newly established Evergreen Fund to spur researchers' efforts to advance bold ideas toward creating or partnering with a commercial entity. [More]
Einstein awarded more than $160 million NIH grant in federal fiscal year 2016

Einstein awarded more than $160 million NIH grant in federal fiscal year 2016

Investigators at Albert Einstein College of Medicine were awarded more than $160 million from the National Institutes of Health in federal fiscal year 2016. [More]
Novel murine model helps shed light on mechanisms involved in reversible infantile liver failure

Novel murine model helps shed light on mechanisms involved in reversible infantile liver failure

Reversible infantile liver failure (RILF) is a heritable mitochondrial condition that causes severe liver dysfunction in infancy, but those who survive the acute stage typically recover and have no further problems. [More]
Combination of diabetes and hypertension drugs can effectively treat cancer

Combination of diabetes and hypertension drugs can effectively treat cancer

A combination of a diabetes medication and an antihypertensive drug can effectively combat cancer cells. [More]
Novel investigational drug may help restore cardiac function after heart failure

Novel investigational drug may help restore cardiac function after heart failure

Cimaglermin, a new experimental drug, may help restore cardiac function after heart failure, according to a first-in-man study published today in JACC: Basic to Translational Science. [More]
Saint Louis University geriatrician urges older patients to talk to doctors about too many pills

Saint Louis University geriatrician urges older patients to talk to doctors about too many pills

If you're 65 or older and taking more than four medications, resolve to talk to your doctor about doing a New Year's triage to make sure too many pills aren't making you sick, advises Milta Little, D.O., associate professor of geriatrics at Saint Louis University. [More]
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