Lung Transplant News and Research

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A pulmonary transplant (or lung transplant) is a surgical procedure in which a diseased lung is removed and replaced with a healthy lung from a donor. A lung transplant will often be recommended if a person has advanced lung disease that is unresponsive to other treatments and/or when a person's life expectancy is likely less than 2-3 years. A lung transplant is considered for those suffering from the following conditions:

UVA launches Fibrosis Initiative to fight the growing cause of death

Fibrosis is often associated with many of the fatal diseases that pervade our globe, riddling organs with stiff tissue that diminishes their flexibility and leads to their failure.

21 Jun 2019

Scientists pinpoint cause of fatal respiratory disorder that turns babies' lips and skin blue

Scientists used a gene editing method called CRISPR/Cas9 to generate mice that faithfully mimic a fatal respiratory disorder in newborn infants that turns their lips and skin blue. The new laboratory model allowed researchers to pinpoint the ailment's cause and develop a potential and desperately needed nanoparticle-based treatment.

19 Jun 2019

Miracle machine makes heroic rescues — and leaves patients in limbo

The latest miracle machine in modern medicine — whose use has skyrocketed in recent years — is saving people from the brink of death: adults whose lungs have been ravaged by the flu; a trucker who was trapped underwater in a crash; a man whose heart had stopped working for an astonishing seven hours.

18 Jun 2019

Mini-biographies help clinicians connect with patients

Bob Hall was recovering from yet another surgery in March 2014 when a volunteer walked into his hospital room. It had been a rocky recovery since his lung transplant three months earlier at the William S. Middleton Memorial Veterans Hospital in Madison, Wis.

10 Jun 2019

Manuka honey could be useful in treating cystic fibrosis lung infection

Researchers at the Swansea University have shown that Manuka honey could be useful in treatment of deadly lung infections caused by antimicrobial resistant respiratory bacteria in cystic fibrosis (CF). The study titled, “Anti-pseudomonad Activity of Manuka Honey and Antibiotics in a Specialized ex vivo Model Simulating Cystic Fibrosis Lung Infection,” was published in the latest issue of the journal Frontiers of Microbiology.

30 May 2019

British teenager with life-threatening infection successfully treated with phage therapy

Doctors report success after treating a British teenager with bacteriophages. The case study is a step forward in the fight against antibiotic resistance.

9 May 2019

NIH-funded trial demonstrates safety of potential treatment in lung transplant patients

A new study, presented today at the American Association for Thoracic Surgery's 99th Annual Meeting, shows that a potential treatment for ischemia- reperfusion injury is safe for humans.

6 May 2019

Study finds link between common virus and faster disease progression in cystic fibrosis

A new study has found that cystic fibrosis patients who have a common virus may experience faster disease progression than patients who do not have the virus. Signs of faster cystic fibrosis disease progression included earlier times to lung transplant referral and reaching the final stages of the disease.

8 Apr 2019

Hepatitis C-infected thoracic organs can be safely transplanted, study finds

Infectious diseases experts and transplant physicians and surgeons at Brigham and Women's Hospital have blocked the transmission of hepatitis C from infected organ donors to recipients in need of hearts or lungs.

4 Apr 2019

Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis

A synthetic peptide appears to directly disrupt the destructive inflammation that occurs in nephritis, enabling the kidneys to better recover and maintain their important functions, investigators report.

25 Mar 2019

Penn researchers cure nine HCV patients following heart transplants from infected donors

Nine patients at Penn Medicine have been cured of the Hepatitis C virus (HCV) following lifesaving heart transplants from deceased donors who were infected with the disease, according to a study published in the American Journal of Transplantation.

25 Feb 2019

Study uncovers new clues to lung transplant rejection

A lung transplant often remains the only option for many patients with end-stage lung disease, a condition that can be brought on by emphysema, pulmonary fibrosis, cystic fibrosis and other lung disorders.

4 Feb 2019

New clinical practice guideline on home oxygen therapy for children

The American Thoracic Society has developed a new clinical practice guideline for home oxygen therapy for children. The guideline appears in the Feb. 1 edition of the Society's American Journal of Respiratory and Critical Care Medicine.

4 Feb 2019

MUSC researchers identify potential therapeutic target for lung fibrosis

In an article published online by Frontiers in Endocrinology, researchers at the Medical University of South Carolina report that they have identified a potential therapeutic target for lung fibrosis or scarring.

19 Dec 2018

Study finds elevated lung cancer risk after lung transplantation

In an American Journal of Transplantation study, lung cancer risk was increased after lung transplantation, especially in the native (non-transplanted) lung of single lung transplant recipients.

19 Dec 2018

New study confirms geographic bias in lung allocation for transplant

Results of a medical records study of more than 7,000 patients awaiting a lung transplant in the United States affirm the basis of a court filing in 2017 that called the organ allocation system geographically "rigged" in some regions of the nation.

17 Dec 2018

Protein which plays role in sensing cell damage serves as new target to treat pulmonary hypertension

A protein with a role in sensing cell damage and viral infections is a new target for the treatment of pulmonary hypertension, or increased blood pressure in the lungs, according to research led by Virginia Commonwealth University and the University of Sheffield in the United Kingdom.

16 Nov 2018

Study uncovers important role of PRMT1 in dilated cardiomyopathy

In a study published in iScience, Professor Akiyoshi Fukamizu of the Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (University of Tsukuba, JAPAN) and the research group reported a new work on discovery of the important role of PRMT1 in dilated cardiomyopathy.

16 Oct 2018

AmpliPhi receives positive feedback from FDA for its AB-PA01 product targeting P.aeruginosa infections

AmpliPhi Biosciences Corporation, a clinical-stage biotechnology company focused on precisely targeted bacteriophage therapeutics for antibiotic-resistant infections, today announced that the company has received positive feedback, via written response, from the U.S. Food and Drug Administration regarding its development plans for AB-PA01, without the need for a Type B Pre-IND meeting.

19 Sep 2018

Cedars-Sinai receives $12 million from NIH to investigate deadly lung conditions

A scientific team led by Cedars-Sinai has been awarded $12 million from the National Institutes of Health to investigate two deadly lung conditions: idiopathic pulmonary fibrosis and chronic lung allograft dysfunction.

11 Sep 2018