Lynch Syndrome News and Research

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Newly established Precision Immunotherapy Clinic matches cancer patients to latest treatments

A third occurrence of colon cancer and a failed immunotherapy clinical trial left Gordon Levine confined to a wheelchair with large tumors in his right hip bone, spine and lung, plus smaller tumors throughout his body, including one that caused an obstruction in his colon.

17 Oct 2019

Use of molecular biomarkers shows promise in early detection of endometrial cancer

The use of molecular biomarkers in minimally invasive sampling opens a promising perspective for the early detection of endometrial cancer.

18 Jun 2019

Promega launches MSI educational website

Researchers and clinicians seeking to deepen their understanding of Microsatellite Instability have a new resource gathering information in one place.

From Promega Corporation 4 Jun 2019

Colorecal cancer commonly misdiagnosed in patients under 50

A recent survey has found that a significant number of patients who develop colorectal cancer (CRC) before the age of 50 are misdiagnosed several times.

1 Apr 2019

Study finds underutilization of aspirin to prevent colorectal cancer in high risk patients

Colorectal cancer is the third most common cause of cancer deaths in the United States and advanced colorectal polyps are a major risk factor.

7 Feb 2019

Novel personalized medicine tool for assessing inherited colorectal cancer syndrome risk developed

An international team of researchers led by Huntsman Cancer Institute at the University of Utah has developed, calibrated, and validated a novel tool for identifying the genetic changes in Lynch syndrome genes that are likely to be responsible for causing symptoms of the disease.

10 Dec 2018

New massive sequencing platform implemented for double factor preimplantation genetic testing

A research team from the Universitat Autònoma de Barcelona, in collaboration with the Blood and Tissue Bank of Catalonia, has managed to implement a massive sequencing platform for Preimplantation Genetic Testing for the first time in history.

5 Dec 2018

Genetic testing can play a substantial role in medical management

Genetic testing can play a substantial role in medical management by uncovering changes in genes that are associated with an increased risk for hereditary cancers.

26 Sep 2018

Charity introduces new Hereditary Cancer Risk Tool to fight ovarian cancer

Around 15% of ovarian cancer cases are linked to genetic mutations such as BRCA1, BRCA2 and Lynch Syndrome, which increase an individual's likelihood of developing ovarian and other cancers. This equates to over 1,000 women a year in the UK whose lives could potentially be saved.

13 Jun 2018

Genomic markers can predict lynch syndrome across tumor types

Microsatellite instability and DNA mismatch repair deficiencies can predict Lynch syndrome across tumor types, according to researchers from Memorial Sloan Kettering Cancer Center, who presented this retrospective data analysis in a press conference at the annual meeting of the American Society of Clinical Oncology.

4 Jun 2018

Are you and your primary care doc ready to talk about your DNA?

If you have a genetic mutation that increases your risk for a treatable medical condition, would you want to know? For many people the answer is yes. But such information is not commonly part of routine primary care.

22 May 2018

Precancerous colon polyps in Lynch syndrome patients display immune activation

Colon polyps from patients with Lynch syndrome, a hereditary condition that raises colorectal cancer risk, display immune system activation well before cancer development, according to research from The University of Texas MD Anderson Cancer Center.

16 Apr 2018

Genomic test effective for detecting Lynch syndrome in CRC patients

A single, upfront genomic test is more effective for detecting Lynch syndrome in colorectal cancer (CRC) patients than the traditional multiple, sequential testing approach, according to new clinical data reported by The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

29 Mar 2018

Benefits of Biomarkers in Colorectal Cancer Treatment

Biomarkers fall into different categories: diagnostic biomarkers, are used to identify a disease; prognostic biomarkers, help clinicians to determine, for example, whether you're more likely to die or have problems with a disease; and there are some that can be used to inform treatment, to determine whether one therapy would be more successful than another.

2 Oct 2017

Risk factors, symptoms, diagnosis and treatment of ovarian cancer

Ovarian cancer is the 9th most common cancer in women and although it only accounts for approximately 3 percent of cancers in women, it is responsible for the most deaths of any cancer involving the female reproductive tract.

20 Sep 2017

Safe under the ACA, patients with preexisting conditions now fear bias

Cheasanee Huette, a 20-year-old college student in Northern California, is worried. Two years ago, knowing she was protected by the Affordable Care Act's guarantees of coverage for preexisting conditions, she decided to find out if she carried the same genetic mutation that eventually killed her mother.

29 Jun 2017

Raising age limit for routine genetic testing in colorectal cancer could identify more cases of Lynch syndrome

Raising the age limit for routine genetic testing in colorectal cancer could identify more cases of families affected by Lynch syndrome, a condition that accounts for around 5% of all colon cancers, according to new research to be presented at the annual conference of the European Society of Human Genetics today (Monday).

29 May 2017

Michigan Medicine opens first clinic in the United States that focuses on prostate cancer risk

It's well known that women with certain hereditary genetic mutations, particularly BRCA1 and BRCA2, have an increased risk of breast cancer. But in recent years, researchers have discovered a link between some of those same genetic mutations - along with a handful of others - and aggressive prostate cancer.

3 Mar 2017

Testing for Lynch syndrome: an interview with Kevin Monahan

Lynch syndrome is an inherited condition which causes about 1,100 cases of bowel cancer and 1,000 other cancers annually in the UK. It is caused by a fault in the mismatch repair gene (MMR) which usually works to prevent cancer.

21 Nov 2016

Researchers underscore importance of immune-based prevention to conquer cancer

In a Perspective piece published this week in PNAS, cancer researchers from across the country, including faculty at University of California San Diego School of Medicine and Moores Cancer Center, write that a greater emphasis on immune-based prevention should be central to new efforts like the federal Cancer Moonshot program, headed by Vice President Joe Biden.

19 Sep 2016