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Novel machine learning-based approach used to predict hepatotoxic potential of DNA drug

New classes of therapeutic antisense oligonucleotides can have toxic effects on the liver. A novel machine learning-based approach used to predict the hepatotoxic potential of an antisense drug based on its chemical sequence is presented in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers.

28 Aug 2013

Shape and meaning: A study explores how brain encodes visual objects

Opening our eyes and seeing the world before us, full of objects, is a simple action we may take for granted. Yet our brain is constantly carrying out a huge analysis only to let us see a flower, a pen, the face of our children.

12 Aug 2013

Wiring diagram of retinal neurons: The first step toward mapping the human brain

The human brain has 100 billion neurons, connected to each other in networks that allow us to interpret the world around us, plan for the future, and control our actions and movements. MIT neuroscientist Sebastian Seung wants to map those networks, creating a wiring diagram of the brain that could help scientists learn how we each become our unique selves.

8 Aug 2013

Combining drugs that target AXL and ErbB receptors could offer better way to fight tumors

Cancer drugs known as ErbB inhibitors have shown great success in treating many patients with lung, breast, colon and other types of cancer. However, ErbB drug resistance means that many other patients do not respond, and even among those who do, tumors commonly come back.

7 Aug 2013

Study looks at correlation between reading ability and brain structure

A combination of brain scans and reading tests has revealed that several regions in the brain are responsible for allowing humans to read.

6 Aug 2013

MUCMD Symposium to be held at The Saban Research Institute of Children's Hospital Los Angeles

On August 16 and 17, the 3rd annual Meaningful Use of Complex Medical Data Symposium is returning to The Saban Research Institute of Children's Hospital Los Angeles.

23 Jul 2013

Researchers develop new test to detect E. coli at food processing facilities

Medical, agriculture and computer science researchers from the University of Alberta have teamed up to develop a test that will make Canadians feel safer about the meat they put on their tables.

16 Jul 2013

Apixio, Dell collaborate to develop business intelligence applications for healthcare clients

Apixio Inc., the leading provider of Big Data analytic and clinical data integration for healthcare, and Dell are collaborating to offer solutions that enable healthcare systems to improve performance management and reporting.

5 Jun 2013

IUPUI professor earns CAREER award for improving machine learning technology

A computer science professor at Indiana University-Purdue University Indianapolis (IUPUI) has earned the prestigious CAREER Award from the National Science Foundation (NSF) to research ways to help computers actively adjust models and classify new data by enhancing machine learning technology.

5 Apr 2013

Finnish researchers develop triumphant solution to predict breast cancer cells’ responses to drugs

The answer is yes. Finnish researchers have developed a triumphant solution for predicting responses of breast cancer cells to a set of cancer drugs. The prediction is based on the genomic profiles of the cancer cells. Harnessing genomic profiles of cells in choosing the best treatment is considered the holy grail of personalised medicine.

20 Nov 2012

Princeton neuroscientists to explore how human brain accomplishes real-world tasks

Princeton neuroscientists have been awarded a $4 million grant from the John Templeton Foundation to explore how the human brain enables us to pursue goals and juggle priorities in an environment full of distractions.

14 Nov 2012

Researchers succeed in teaching computers how to identify commonalities in DNA sequences

Johns Hopkins researchers have succeeded in teaching computers how to identify commonalities in DNA sequences known to regulate gene activity, and to then use those commonalities to predict other regulatory regions throughout the genome. The tool is expected to help scientists better understand disease risk and cell development.

7 Nov 2012

Researchers combine robotics, machine learning and brain imaging to assist infants with CP

Learning to crawl comes naturally for most infants, but those with cerebral palsy lack the muscle strength and coordination to perform the 25 individual movements required for crawling. With a $1.135 million, three-year grant from the National Science Foundation's National Robotics Initiative, University of Oklahoma researchers from the Norman and Health Sciences Center campuses are combining robotics, machine learning and brain imaging to assist infants with CP with the challenging, life-altering skill.

2 Nov 2012

Study compares gene expression levels in two key hippocampal regions affected by Alzheimer's

Researchers from the Computational Intelligence Group based at the Universidad Politécnica de Madrid's Facultad de Informática have used machine learning and data mining techniques to compare gene expresssion levels in Alzheimer's disease (AD) patients in two key regions of the hippocampus: the dentate gyrus, where the disease appears to have little or no effect, and the entorhinal cortex, where Alzheimer's disease produces major neuronal damage.

10 Oct 2012

Pregnancy exposures may increase risk of breast cancer in multiple generations of offspring

Chemicals or foods that raise estrogen levels during pregnancy may increase cancer risk in daughters, granddaughters, and even great-granddaughters, according to scientists from Virginia Tech and Georgetown University.

12 Sep 2012

Massachusetts Institute of Technology to honor IHME's health measurement expert

For the first time, a prestigious technical innovation honor from the Massachusetts Institute of Technology (MIT) will go to an expert in health measurement: Abraham Flaxman, an Assistant Professor of Global Health at the Institute for Health Metrics and Evaluation (IHME) at the University of Washington (UW).

22 Aug 2012

Scientists demonstrate automated worm sorter for biological research

Research into the genetic factors behind certain disease mechanisms, illness progression and response to new drugs is frequently carried out using tiny multi-cellular animals such as nematodes, fruit flies or zebra fish.

20 Aug 2012

Riverain's ClearRead Bone Suppression software improves detection of lung cancer

Software by Riverain Technologies significantly improves radiologists' ability to detect potentially cancerous lung nodules in X-ray images, and might be a cost-effective alternative to dual energy subtraction (DES) imaging, according to two new studies being presented at the 20th Anniversary Meeting of the European Society of Thoracic Imaging (ESTI), June 22-24, in London.

23 Jun 2012

Distinctive protein pathways in certain leukemia patients

Scientists at Rice University and the University of Texas MD Anderson Cancer Center have successfully profiled protein pathways found to be distinctive to leukemia patients with particular variants of the disease.

1 Jun 2012

Researchers develop tentative model for diagnosis of colon cancer

Researchers from the Universidad Politécnica de Madrid's Facultad de Informática, the Universidad del País Vasco, the Gaiker Technology Centre (Biscay) and the Hospital de Cruces in Barakaldo, have developed a tentative model for the diagnosis of colon cancer based on a biomarker panel.

28 May 2012