Macromolecules News and Research

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Researchers develop novel technology to produce cheaper, longer-lasting vaccines

A new method to produce vaccines that have a longer shelf-life, are cheaper and can be stored without the need for cooling is being presented in the open access journal BMC Biotechnology.

21 Jan 2020

Measuring glycans in samples of antibodies

When Lorna De Leoz invited laboratories to participate in her glycomics study, she hoped for 20 responses. Instead, she was deluged by emails from around the world.

2 Jan 2020

Targeting specific nuclear transport systems may lead to possible therapeutic strategies for cancer

Although less often the focus of cancer research, recent studies have hinted at the possible importance of a type of protein known as nuclear transport receptors.

17 Dec 2019

New Method of Creating Synthetic DNA Nanopores

A team has created a synthetic DNA nanopore that can translocate protein-sized macromolecules across lipid bilayers selectively.

16 Dec 2019

Researchers reconstruct the evolutionary history of metabolism

By analyzing how metabolic enzymes are built and organized, researchers have reconstructed the evolutionary history of metabolism. Their study shows how metabolic networks - which drive every cellular process from protein building to DNA repair - became less random, more modular and more hierarchical over time, the researchers say.

29 Oct 2019

Study shows how electrostatic interactions can be regulated to control scroll-like cochleate structures

Northwestern Engineering materials science researchers have uncovered new insights into how electrostatic interactions can be regulated to attain and control scroll-like cochleate structures, which could inform how to capture and release macromolecules in a size-selective manner as part of future drug-delivery strategies.

16 Oct 2019

Structural biology reveals 3D structure of asthma-linked receptor

A new study has laid bare the structure of a protein receptor called the CysLT1 receptor that is implicated in a range of allergic and cardiovascular conditions as well as some types of cancer. Published in Science Advances, the paper shows how the researchers used structural biology techniques to accomplish this feat.

10 Oct 2019

Study shows how AF4-MALS-UV can separate and size large AAV aggregates

Postnova Analytics has published a new applications study that reports on how Asymmetric Flow Field Flow Fractionation (AF4) coupled with multi-angle light scattering (MALS) and Ultraviolet (UV) detectors can be used to quantify Adeno-Associated Virus (AAV) aggregation.

From Postnova Analytics 25 Sep 2019

Newly synthesized anticancer compound can block cancer signaling mechanism

Of the various different functions that proteins perform in a cell, a crucial one is the recognition and transmission of certain "signals," collectively referred to as signal transduction.

24 Sep 2019

Researchers develop world's first blood incubator using laser technology

Researchers from BioPRIA, based at Australia's Monash University, together with industry partner Haemokinesis, have developed the world's first blood incubator using laser technology.

20 Sep 2019

Researchers study biological risk potential of nanoparticles

Nanoparticles are smaller than five nanometres - a nanometre being one millionth of a millimetre - which corresponds approximately to the size of macromolecules. Such tiny particles are very easily absorbed in body cells.

27 Aug 2019

Strong free-electron lasers can be used to break down amyloid protein aggregates

Amyloid fibrils are a type of self-assembled proteins/peptides that take on a stacked sheet-like formation. Amyloid fibril aggregates are known to be a cause of several diseases--including Alzheimer's--and therefore, it is of immense scientific interest to understand how these aggregates can be broken.

8 Aug 2019

Understanding how positively charged peptides formed on pre-biotic earth

Earth didn't always harbor life. But around 4 billion years ago, something in the environment changed, and systems with biological properties began to emerge.

2 Aug 2019

Researchers publish review on serial femtosecond crystallography

Researchers from the Moscow Institute of Physics and Technology have published a review on serial femtosecond crystallography, one of the most promising methods for analyzing the tertiary structure of proteins.

22 Jul 2019

New combination method improves characterization of polysaccharides

Postnova Analytics reports on a new method for the accurate molecular weight determination of complex polysaccharides (Chitosans) using asymmetric flow field flow fractionation (AF4) coupled with multi-angle light scattering (MALS) and differential refractive index (RI) detectors.

From Postnova Analytics 16 Jul 2019

Using NMR to Study Protein Structure, Dynamics and Mechanisms

Fábio Almeida describes how NMR can be used to elucidate protein structure and how this data can be applied to human disease.

From Bruker BioSpin - NMR, EPR and Imaging 4 Jul 2019

Characterizing and Isolating (Bio)macromolecular Structures using MALS

In this interview, Albena Lederer, Head of the Polymer Separation Group at the Leibniz Institute for Polymer Research, talks to News-Medical Life Sciences about the techniques and methods used to understand and analyze polymers.

From Waters | Wyatt Technology 26 Jun 2019

Healthy blood vessels could help stave off cognitive decline

High blood pressure may affect conditions such as Alzheimer’s disease by interfering with the brain’s waste management system, according to new research in rats published in JNeurosci. Maintaining blood vessel health could therefore help stave off cognitive decline.

From Society for Neuroscience 19 Jun 2019

Investigating RNA-based regulation of the cardiovascular system

Goethe University and TU Munich have jointly obtained a new Collaborative Research Centre (Sonderforschungsbereich - SFB), which will receive approximately € 11 million in funding from the German Research Foundation over the next four years.

27 May 2019

$New book introduces scientists to thermal field-flow fractionation of polymers$

New book introduces scientists to thermal field-flow fractionation of polymers

Postnova Analytics reports on an informative new book that introduces scientists to thermal field-flow fractionation and discusses its advantages over the fundamental problems associated with traditional column-based analytical techniques commonly used to characterize polymers and macromolecules.

From Postnova Analytics 25 Apr 2019