Mammary Gland News and Research

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Loss of specific protein makes breast cancers more aggressive, resistant to chemotherapy

Researchers in Italy have discovered how specific versions of a protein called Numb protect the key tumor suppressor p53 from destruction.

21 Dec 2017

Researchers identify previously unknown breast cell types

A joint effort by breast cancer researchers and bioinformaticians has provided new insights into the molecular changes that drive breast development.

21 Nov 2017

Scientists discover novel lineage-restricted stem cell in the mammary gland

One of the key questions in stem cell and cancer biology is to understand the cellular hierarchy governing tissue development and maintenance and the cancer cell of origin.

16 Aug 2017

Researchers identify small RNA molecule that promotes deadly forms of breast cancer

Researchers from Princeton University's Department of Molecular Biology have identified a small RNA molecule that helps maintain the activity of stem cells in both healthy and cancerous breast tissue.

23 May 2017

Study: Cancer cells grow faster when transplanted into fatty, obese tissue

It's not just what's inside breast cancer cells that matters. It's also the environment surrounding cancer cells that drives the disease, according to researchers at the University of North Carolina Lineberger Comprehensive Cancer Center.

31 Mar 2017

Adolescent, early adult diet linked to chronic inflammation may increase premenopausal breast cancer risk

Women who consumed a diet as adolescents or young adults associated with chronic inflammation had a higher risk for premenopausal breast cancer compared with those whose adolescent and early adulthood diet was not associated with chronic inflammation.

1 Mar 2017

Study finds biochemical pathway that triggers regrowth of breast cancer stem cells after chemotherapy

Working with human breast cancer cells and mice, researchers at Johns Hopkins say they have identified a biochemical pathway that triggers the regrowth of breast cancer stem cells after chemotherapy.

22 Feb 2017

Research findings could offer novel approach for cancer prevention in women with BRCA1 mutations

Women with inherited mutations in the BRCA1 or BRCA2 genes are at substantially higher risk of breast cancer. For these women, effective prevention strategies are their best hope to reduce their breast cancer risk.

16 Dec 2016

New 3-D mammary gland model may pave way for better understanding of breast cancer

A team of researchers from Cardiff University and Monash Biomedicine Discovery Institute has succeeded in creating a three-dimensional mammary gland model that will pave the way for a better understanding of the mechanisms of breast cancer.

27 Oct 2016

Finnish researchers identify molecular mechanism that controls migration of early macrophages

Leukocytes which arise during the embryonic period regulate iron metabolism and the growth of the mammary gland in adults.

17 Oct 2016

Study identifies new gene that suppresses breast cancer in mice

In recent years, the incidence of breast cancer has been increasing worldwide, and breast cancer is becoming a serious object of public concern.

13 Sep 2016

Inhibition of RANK signaling pathway could be potential new therapy in breast cancer

Researchers at the Institute of Biomedical Research of Bellvitge, led by Dr. Eva Gonzalez-Suarez, have shown that pharmacological and genetic inhibition of signaling pathway RANK / RANKL leads to a significant reduction in recurrences and metastases in breast cancer in a mouse animal model.

13 Sep 2016

Health-promoting bacteria may protect women from breast cancer

Bacteria that have the potential to abet breast cancer are present in the breasts of cancer patients, while beneficial bacteria are more abundant in healthy breasts, where they may actually be protecting women from cancer, according to Gregor Reid, PhD, and his collaborators.

25 Jun 2016

Novel methods may help assess multipotent or unipotent fate of mammary gland, prostate stem cells

Stem cells ensure the development of tissues, their daily maintenance and their repair following injuries. One of the key questions in the field of stem cell biology is to define the different cell lineages in which stem cells can differentiate into.

9 Jun 2016

Study reveals surprising results that may impair future therapeutic approaches in TGF-beta pathway

Researchers at Helmholtz Zentrum München describe how breast cancer cells challenged with a small-molecule inhibitor targeting specific invasive properties switch to an alternative mode-of-action, rendering them even more aggressive. The results may impair future therapeutic approaches in the TGF-beta pathway and are published in the journal 'Oncotarget'.

27 Apr 2016

Low doses of bisphenol A can affect development of metabolism, reproductive and nervous systems

If rats are exposed to bisphenol A in low doses during early development it can lead to reduced sperm count, obesity and changes to breast development and behaviour. These are some of the findings of a new study from the National Food Institute, Technical University of Denmark. The results support previous animal studies, which have shown that low doses of bisphenol A can affect development of the metabolism as well as the reproductive and nervous systems.

19 Apr 2016

New study shows link between FZD7 protein and breast cancer development

A new study shows that Frizzled7 (FZD7), a protein present on human breast epithelial cells and a component of the Wnt signaling pathway is uniquely controlled by the Notch signaling pathway, both of which play key roles in mammary gland formation and breast cancer development.

6 Apr 2016

Cells communicate to their neighbors and compare notes before making a move

To decide whether and where to move in the body, cells must read chemical signals in their environment. Individual cells do not act alone during this process, two new studies on mouse mammary tissue show. Instead, the cells make decisions collectively after exchanging information about the chemical messages they are receiving.

22 Jan 2016

Sugary Western diet may increase risk of breast cancer and metastasis to the lungs

The high amounts of dietary sugar in the typical Western diet may increase the risk of breast cancer and metastasis to the lungs, according to a study at The University of Texas MD Anderson Cancer Center.

4 Jan 2016

Zinc levels in breast milk may help identify breast-feeding problems

Zinc levels in breast milk may be able to serve as an indicator of breast function during lactation, according to Penn State health researchers.

23 Dec 2015