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Bipolar brain changes both state- and trait-dependent

Bipolar brain changes both state- and trait-dependent

Some of the alterations in brain activation in patients with bipolar disorder are dependent on their current mood, study findings show. [More]
Quitting cannabis use during manic episodes improves outcomes

Quitting cannabis use during manic episodes improves outcomes

A post-hoc analysis of data from a prospective European study reveals that patients with bipolar disorder who stop using cannabis during a manic or mixed episode have similar clinical and functional outcomes to those who have never used the drug. [More]
UC Berkeley study finds self-worth key to diagnoses of psychopathologies

UC Berkeley study finds self-worth key to diagnoses of psychopathologies

Donald Trump's ego may be the size of his financial empire, but that doesn't mean he's the picture of mental health. The same can be said about the self-esteem of people who are living from paycheck to paycheck, or unemployed. New research from the University of California, Berkeley, underscores this mind-wallet connection. [More]
Depressive episodes hard to treat in continuous cycling bipolar disorder

Depressive episodes hard to treat in continuous cycling bipolar disorder

Patients with bipolar disorder who switch directly between mania and depression without a period of euthymia have a poor response to short-term antidepressant treatment, study findings indicate. [More]

Bipolar mixed episodes increase significantly under DSM-5

Using the most recent diagnostic criteria increases the prevalence of mixed features in patients with bipolar disorder more than threefold, study findings indicate. [More]
Transition Therapeutics presents Phase 2 study of ELND005 drug for bipolar disorder

Transition Therapeutics presents Phase 2 study of ELND005 drug for bipolar disorder

Transition Therapeutics Inc. ("Transition" or the "Company") today announced findings from a Phase 2 study of neuropsychiatric drug candidate, ELND005, as an adjunctive maintenance treatment for bipolar disorder type I patients (BPD). [More]
Verbal abuse worsens bipolar disease outcome

Verbal abuse worsens bipolar disease outcome

Experiencing verbal abuse in childhood has a lasting negative effect on the course of bipolar disorder, researchers have found. [More]
UMMS, UMMSM researchers identify key genetic pathway underlying bipolar disorder

UMMS, UMMSM researchers identify key genetic pathway underlying bipolar disorder

A team of scientists led by researchers at the University of Massachusetts Medical School and the University of Miami Miller School of Medicine have identified what is likely a key genetic pathway underlying bipolar (manic depressive) disorder, a breakthrough that could lead to better drugs for treating bipolar affective disorder, as well as depression and other related mood disorders. [More]

Clinical pointers to bipolar, unipolar depression confirmed

A large study confirms several factors that can distinguish patients with bipolar depression from those with unipolar depression, including higher trait impulsivity, aggression and hostility. [More]
Clinical practice study supports ISBD recommendations

Clinical practice study supports ISBD recommendations

Findings in patients with bipolar disorder given short-term antidepressant treatment support the recent International Society for Bipolar Disorder’s task force recommendations. [More]
Weight cycling linked to relapse-prone bipolar course

Weight cycling linked to relapse-prone bipolar course

Patients with bipolar disorder are more likely than healthy controls to have a history of weight cycling, which in turn is associated with an increased likelihood of manic and depressive episodes, researchers report. [More]
Benefits and risks of hatha yoga for people with bipolar disorder

Benefits and risks of hatha yoga for people with bipolar disorder

Right now no one can say whether yoga provides clinical benefits to people with bipolar disorder, but in a new article in the Journal of Psychiatric Practice, researchers report survey responses they gathered from scores of people with the condition who practice yoga. What the collective testimony suggests is that yoga can be a substantial help, but it sometimes carries risks, too. [More]

Cyclothymic temperament linked to suicidality

The presence of a cyclothymic temperament in inpatients with bipolar disorder may indicate a high likelihood of hopelessness and suicidality, report researchers. [More]
FDA approves Contrave extended-release tablets for chronic weight management

FDA approves Contrave extended-release tablets for chronic weight management

Takeda Pharmaceuticals U.S.A., Inc. and Orexigen® Therapeutics, Inc. jointly announced today that the U.S. Food and Drug Administration has approved Contrave® extended-release tablets as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index of 30 kg/m2 or greater (obese), or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition. [More]
Optimal personalised treatment improves bipolar life quality, functioning

Optimal personalised treatment improves bipolar life quality, functioning

Optimal personalised treatment improves quality of life and functioning of patients with bipolar disorder type I or II, suggests research published in the Journal of Affective Disorders. [More]
Aberrant reward processing likely to precede bipolar symptom onset

Aberrant reward processing likely to precede bipolar symptom onset

Healthy children who have a parent with bipolar disorder show altered brain activation during reward processing, research shows. [More]
Earlier treatment better for bipolar patients

Earlier treatment better for bipolar patients

Patients with bipolar disorder are more likely to respond to lithium if the treatment is started early in the course of the condition, say researchers. [More]
Viewpoints: Parsing newest reports of coverage gains; 'scientific fraudsters'

Viewpoints: Parsing newest reports of coverage gains; 'scientific fraudsters'

It will take a while to understand fully how the Affordable Care Act affects the quality of health care and access to doctors in this country. [More]
Factors linked to bipolar cycle acceleration identified

Factors linked to bipolar cycle acceleration identified

Researchers have identified factors that are associated with cycle acceleration in patients with bipolar disorder admitted to hospital for a mood episode. [More]
Researchers identify genetic mutation that may cause parkinsonism in young people

Researchers identify genetic mutation that may cause parkinsonism in young people

Researchers at the University of Copenhagen and the Copenhagen University Hospital have identified a particular genetic mutation that may cause parkinsonism in young people. The mutation interferes with the brain's transport of the important signal substance dopamine and may also plays a role in mental diseases, e.g. ADHD. [More]