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New version of obesity drug could help people reduce weight without experiencing anxiety, depression

New version of obesity drug could help people reduce weight without experiencing anxiety, depression

A new version of an obesity drug that caused serious psychiatric side effects could help people lose pounds without experiencing the anxiety, depression and suicidal thoughts previously associated with it. The research, published in Bioorganic and Medicinal Chemistry, shows that the new version of the drug can still work without reaching the brain in rats, avoiding the side effects. [More]

TSRI chemists develop new method to achieve chemical reaction in pharmaceutical industry

Scientists at The Scripps Research Institute have found a new and better way to achieve a chemical reaction that is used widely in the pharmaceutical as well as flavor and fragrance industries. [More]
U of S-led researchers develop novel class of compounds for effective cancer treatment

U of S-led researchers develop novel class of compounds for effective cancer treatment

A novel class of compounds developed by a University of Saskatchewan-led research team could yield more effective and less toxic chemotherapy drugs to treat cancer. [More]
France-based pharmaceutical company deploys Porvair Sciences' Ultravap Mistral in medicinal chemistry department

France-based pharmaceutical company deploys Porvair Sciences' Ultravap Mistral in medicinal chemistry department

Porvair Sciences reports that a major Pharmaceutical company based in France has integrated its Ultravap Mistral blowdown evaporation system with a Hamilton Star robotic liquid handling system to enhance new drug candidate processing in its medicinal chemistry department. [More]
WSU researcher explores new drugs to treat neurological disorders linked to autophagic dysfunction

WSU researcher explores new drugs to treat neurological disorders linked to autophagic dysfunction

Repairing the brain's "house-cleaning function," which could help people with Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS) and 100 other diseases, is the focus of recently funded research at Washington State University. [More]
Scientists synthesize novel selenohydantoins with anticancer and antioxidant activity

Scientists synthesize novel selenohydantoins with anticancer and antioxidant activity

A group of scientists from Moscow universities led by Yan Ivanenkov, the head of Laboratory of Medical Chemistry and Bioinformatics in MIPT, has succeeded in synthesizing a set of novel selenohydantoins with anticancer and antioxidant activity. [More]
Researchers aim to design a better male contraceptive pill

Researchers aim to design a better male contraceptive pill

Women can choose from a wide selection of birth control methods, including numerous oral contraceptives, but there's never been an analogous pill for men. That's not for lack of trying: For many years, scientists have attempted to formulate a male pill. Finally, a group of researchers has taken a step toward that goal by tweaking some experimental compounds that show promise. [More]
Scientists discover novel drug candidate to treat breast cancer, lung cancer and melanoma

Scientists discover novel drug candidate to treat breast cancer, lung cancer and melanoma

Using a new approach, scientists at The Scripps Research Institute and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung cancer and melanoma. [More]
New vaccine delays effects of nicotine within first 10 minutes after injection

New vaccine delays effects of nicotine within first 10 minutes after injection

Many people who smoke want to quit, but the urge to light up is often irresistible. An effective vaccine to help people kick the habit once and for all has been elusive. But now, scientists report in ACS' Journal of Medicinal Chemistry a new vaccine design that could help achieve this goal. [More]
Advances in medicinal chemistry evaporators: an interview with Alison Wake, Genevac

Advances in medicinal chemistry evaporators: an interview with Alison Wake, Genevac

The Genevac Series 1 System, which was launched in the mid 1990s, had no programming as such. It was a very basic system – it had basic vacuum control and a timer of sorts. It was very similar to the current myVac evaporator system we use for molecular biology and biological applications. [More]
New screening technique to test drug compounds used in Ewing sarcoma treatment

New screening technique to test drug compounds used in Ewing sarcoma treatment

In Ewing sarcoma, cancer cells' DNA is unwound abnormally from a condensed, compact state. Once sections of genetic code are open, key genes are turned on to help direct aggressive and cancerous cell growth. [More]
Anti-biofilm compounds show promise against drug-resistant bacteria associated with hospital-acquired infections

Anti-biofilm compounds show promise against drug-resistant bacteria associated with hospital-acquired infections

Researchers at the University of Michigan Life Sciences Institute and School of Public Health have discovered a new class of anti-biofilm compounds derived from marine microorganisms that show promise against a drug-resistant bacterium commonly associated with hospital-acquired infections. [More]
Leeds scientists to start computer drug research to find cure for Ebola virus

Leeds scientists to start computer drug research to find cure for Ebola virus

Scientists at the University of Leeds will run the equivalent of password cracking software to find the chemical keys to defeating the Ebola virus. [More]
Flexible Solution for High Throughput Evaporation

Flexible Solution for High Throughput Evaporation

Genevac Series 3 HT evaporators provide an ideal solution for evaporation bottlenecks in high throughput medicinal chemistry, natural product and production laboratories that generate large numbers of samples for processing. [More]
New study improves understanding of metal-based chemotherapy drugs

New study improves understanding of metal-based chemotherapy drugs

What is the mechanism of action of metal-based chemotherapy drugs (the most widely used for treating common cancers like testicular or ovarian cancer)? How can we improve their effect and reduce their toxicity? A new study combining experiments and theory has broadened our knowledge of the molecular mechanisms of these active drugs to help experimentalists devising increasingly effective drugs with fewer side effects. [More]
TSRI-led study finds potential new therapeutic approach for hard-to-treat breast cancers

TSRI-led study finds potential new therapeutic approach for hard-to-treat breast cancers

Findings from a new study led by scientists from the Florida campus of The Scripps Research Institute (TSRI) suggest a potent new therapeutic approach for a number of hard-to-treat breast cancers. [More]
New funding supports research on new and improved drug treatments for tuberculosis, malaria

New funding supports research on new and improved drug treatments for tuberculosis, malaria

University of Toronto and McGill University scientists are leading an international partnership to discover new and improved drug treatments for tuberculosis, malaria and neglected tropical diseases -- thanks to a contribution from Merck Canada Inc., as well as an additional $5 million supplement to a grant from the Bill & Melinda Gates Foundation. [More]
SLU scientist awarded new $2.2 million NIH grant to develop cure for hepatitis B

SLU scientist awarded new $2.2 million NIH grant to develop cure for hepatitis B

With proof-of-principle in his pocket and a new $2.2 million grant from the National Institutes of Health, SLU scientist John Tavis, Ph.D., will take his 25 year mission to finally develop a cure for the hepatitis B virus into the next phase. [More]
Vagus nerve stimulation prevents hemorrhagic complications following surgery

Vagus nerve stimulation prevents hemorrhagic complications following surgery

Stimulating the vagus nerve is a potentially efficacious and safe way to stop the flow of blood and prevent hemorrhagic complications following surgery and other invasive procedures, according to a researcher in the Center for Bioelectronic Medicine at The Feinstein Institute for Medical Research. [More]
Novel class of antimicrobials could be effective in fighting drug-resistant MRSA infection

Novel class of antimicrobials could be effective in fighting drug-resistant MRSA infection

A novel class of antimicrobials that inhibits the function of a key disease-causing component of bacteria could be effective in fighting methicillin-resistant Staphylococcus aureus (MRSA), one of the major drug-resistant bacterial pathogens, according to researchers at Georgia State University. [More]
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