Mefloquine News and Research

RSS

Nanoparticles take aim at COVID-19 with lysosome-targeted delivery

Researchers discuss the use of endo-lysosome-targeted nanoparticles for delivering antiviral therapy to treat coronavirus infections.

15 May 2023

Laos malaria outbreak in 2020–21 likely caused by multidrug-resistant strains of P. falciparum

Researchers describe the genetic epidemiology and dynamics of the Plasmodium falciparum responsible for malaria outbreaks in Attapeu Province, Laos.

5 Dec 2022

Meta-analysis informs a change to treatment guidelines for uncomplicated malaria in the first trimester of pregnancy

A new WWARN meta-analysis commissioned by the World Health Organization (WHO) which informed a change to its treatment guidelines has been published in The Lancet.

28 Nov 2022

Researchers evaluate artemisinin for COVID-19 management

Researchers assessed the effectiveness of artemisinin-based antimalarials in the management of COVID-19.

16 Jun 2022

World Malaria Day 2022: How the knockdown of P. falciparum RAP01 and RAP21 proteins could lead to novel antimalarial therapeutics

As part of World Malaria Day 2022, we interview Karine Le Roch PH.D., about her latest research into how novel antimalarial therapeutic strategies could be on the horizon, after identifying two proteins that are critical to the survival of the malaria parasite, Plasmodium falciparum.

25 Apr 2022

Chlorophyll catabolite pheophorbide A shows potential against SARS-CoV-2

A new study identifies a potent SARS-CoV-2 antiviral, Pheophorbide a (PheoA), which is a compound derived from the plant Marchantia polymorpha L.

27 Oct 2021

Anti-malarial drug shows promise in the battle against COVID-19

In the "war" that the world has been fighting against COVID-19, scientists have been scanning their arsenals of previously used drugs in hopes of finding any that can be used to treat the disease.

1 Jul 2021

Study reviews natural drug candidates for potential treatment of COVID-19

A recent paper in the Saudi Journal of Biological Sciences seeks to open up new approaches by reviewing a list of compounds derived from plants and other natural sources, which have potential inhibitory activity against the coronavirus.

21 Jun 2021

Study identifies a host of agents with anti-SARS-CoV-2 potential

A team of researchers at the Genomics Research Center, Academia Sinica, in Taiwan, evaluated the efficacy of 2,855 agents against SARS-CoV-2.

22 Jan 2021

Mefloquine shows potential as anti-SARS-CoV-2 drug

A team of scientists from Japan has identified the approved anti-material drug, mefloquine, as a potential candidate to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Specifically, mefloquine has been shown to prevent the entry of SARS-CoV-2 into host cells and reduce the viral load in vitro.

24 Nov 2020

Antimalarials could disrupt SARS-CoV-2’s Nsp1 translation termination

A research team from the Engelhardt Institute of Molecular Biology in Russia have shown that Nsp1 – a non-structured protein present in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen – stimulates translation termination in the stop codon recognition stage. Studying and developing drugs that compete with Nsp1 for binding with the termination complex could therefore be a potential strategy for fighting against coronavirus disease 2019 (COVID-19).

15 Nov 2020

Triple therapies effective and safe in malaria

A new study describing the outcome of a clinical trial of two malaria treatment protocols involving the use of triple therapies based on artemisinin reports their high efficacy and low adverse effects.

12 Mar 2020

Molecular-level understanding of drug interactions could pave way for better malaria treatments

The process of crystallization is central to drug development, petrochemical processing and other industrial actions, but scientists say they still are learning about the complex interactions involved in the building and dissolution of crystals.

16 Jan 2020

Artemisinins are still strongest weapon against malaria, say experts

The powerful medicines known as artemisinins have plenty of mileage in them in the global fight against malaria, and concern about partial resistance has been overstated.

26 Apr 2019

Cochrane review provides clarity about safety of mefloquine for preventing malaria in travelers

Researchers from LSTM Cochrane Infectious Diseases Group publish two systematic reviews this week about the safety of mefloquine (Lariam) for preventing malaria in travelers.

30 Oct 2017

“Super malaria” resistant to standard medications in South East Asia

The spread of a single multidrug resistant malaria parasite strain in Vietnam is cause for alarm say researchers.

25 Sep 2017

Research shows new method for rapidly producing antimalarial drug at industrial scale

Compared to smallpox or typhoid, malaria is proving one of the most challenging human diseases to eradicate - and so remains a real and constant danger to nearly half the world's population.

7 Sep 2017

TB germs' metabolic 'escape pathways' may be neutralized by new drugs to shorten duration of therapy

New research suggests the bacteria that cause tuberculosis alter their metabolism to combat exposure to antimicrobials, and that these metabolic "escape pathways" might be neutralized by new drugs to shorten the troublesome duration of therapy.

31 May 2017

Researchers suggest possible novel target for seizure-blocking medicines

Researchers in the biomedical engineering department at Case Western Reserve University have found that epileptic activity can spread through a part of the brain in a new way, suggesting a possible novel target for seizure-blocking medicines.

24 Jan 2014

Dihydroartemisinin-piperaquine more effective than artemether-lumefantrine in treating malaria

'Dihydroartemisinin-piperaquine is more effective than artemether-lumefantrine, and has fewer side effects than artesunate-mefloquine' concludes a systematic review published by the Cochrane Infectious Disease Group, hosted by LSTM.

21 Jan 2014