Messenger RNA (mRNA) News and Research

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JAX researchers unravel mechanism that enables cancer cells to survive and divide

Some cancer cells have a trick up their sleeve to avoid cell death: boosting maintenance of telomeres, the protective "end caps" on chromosomes, and a research team led by Jackson Laboratory Professor Roel Verhaak reports in Nature Genetics on a newly discovered telomere maintenance mechanism.

31 Jan 2017

New study explores how protein production goes off script when skin cells turn cancerous

Each cell in the body follows a strict protocol for manufacturing the proteins it needs to function.

27 Jan 2017

Synthetic molecule appears to reverse Alzheimer's-related neurological damage

Under ordinary circumstances, the protein tau contributes to the normal, healthy functioning of brain neurons. In some people, though, it collects into toxic tangles that damage brain cells.

25 Jan 2017

Prenatal infection-induced epigenetic modifications may alter brain development in offspring

Maternal infection during pregnancy increases the risk for psychiatric disorders in the child, but the path between the two is something of a mystery.

25 Jan 2017

Mayo Clinic researchers identify genetic promoter that drives lung cancer formation

Researchers at Mayo Clinic have identified a genetic promoter of cancer that drives a major form of lung cancer.

19 Jan 2017

Scientists identify 'molecular barcode' in blood samples that can predict survival of Ebola patients

Scientists have identified a 'molecular barcode' in the blood of patients with Ebola virus disease that can predict whether they are likely to survive or die from the viral infection.

19 Jan 2017

MGH researchers identify protein that may protect tumor-initiating cells in breast cancer

Massachusetts General Hospital investigators have identified a protein that may play an essential role in maintaining a population of tumor-initiating cells (TICs) -- treatment-resistant cells responsible for cancer recurrence and metastasis -- in breast cancer, as well as a compound that appears to reduce the molecule's ability to protect TICs from the effects of chemotherapy.

17 Jan 2017

Surveillance machinery in cells recognizes and destroys defective genetic material, research shows

New research out of Case Western Reserve University School of Medicine describes a mechanism by which an essential quality control system in cells identifies and destroys faulty genetic material. The findings were published online December 23 in Nature Communications.

11 Jan 2017

Johns Hopkins researchers identify new biological target for treating spinal muscular atrophy

Johns Hopkins researchers along with academic and drug industry investigators say they have identified a new biological target for treating spinal muscular atrophy.

9 Jan 2017

UC researchers uncover obesity-related protein's role in leukemia development

Cancer researchers at the University of Cincinnati College of Medicine have found an obesity-associated protein's role in leukemia development and drug response which could lead to more effective therapies for the illness.

22 Dec 2016

TSRI scientists identify potential therapeutic target for age- or Alzheimer's disease-related memory deficits

Scientists from the Florida campus of The Scripps Research Institute have made an important discovery toward the development of drugs to treat age-related memory loss in diseases like Alzheimer's.

7 Dec 2016

New study suggests how risk gene linked to ADHD may work

Genetics play a strong part in the development of attention-deficit/hyperactivity disorder (ADHD), but the path from a gene to risk for the disorder has remained a black box to researchers.

7 Dec 2016

Scientists discover how motors maneuver cells' intricate roadway system

Much like motors power our cars, they also ensure that proteins get to the right place in our cells, and a wide variety of diseases - from cancer to heart problems - can result when they don't.

7 Dec 2016

HD is myopathy as well as neurodegenerative disease, study suggests

Researchers have discovered that mice with Huntington's disease (HD) suffer defects in muscle maturation that may explain some symptoms of the disorder.

29 Nov 2016

TSRI scientists discover precise signaling mechanisms that regulate brain’s motor function

In new findings that could have an impact the development of therapies for a number of currently untreatable brain disorders such as Parkinson’s and Huntington’s diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have found, for the first time, that a specific signaling circuit in the brain is deeply involved in motor activity.

17 Nov 2016

Preconsumption of red wine can prevent short-term vascular injury caused by smoking

Drinking red wine is widely regarded as protective against cardiovascular disease. A new report in The American Journal of Medicine found that a glass or two of red wine before lighting up a cigarette can counteract some of the short-term negative effects of smoking on blood vessels.

15 Nov 2016

Stem-cell-derived gap junction cells could be important therapeutic target for treatment of hereditary deafness

A collaboration, including researchers from Juntendo University, demonstrate differentiation from stem cells into specialised cells thought to be the most important therapeutic target for the treatment of hereditary deafness.

14 Nov 2016

Research reveals new molecular mechanisms of Huntington's disease

The research just published by a group of scientists from the Centre for Genomic Regulation (CRG) in Barcelona, Spain, led by Eulàlia Martí, in cooperation with researchers from the University of Barcelona (UB) and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), has brought to light new information on the molecular mechanisms that cause Huntington’s disease, and defines new pathways to therapy discovery.

8 Nov 2016

Advances in RNA research could pave new way for development of anti-cancer drugs

An international research team led by the University of Leicester has made a breakthrough advance that could pave a new route for the development of anti-cancer drugs.

8 Nov 2016

Researchers identify heart defects in progeria patients that may raise risk of arrhythmias, premature death

Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III, working in collaboration with colleagues at other centers in Spain and abroad, have identified defects in the hearts of progeria patients that appear to be related to an elevated risk of arrhythmias and premature death.

2 Nov 2016

Messenger RNA (mRNA) News and Research

JAX researchers unravel mechanism that enables cancer cells to survive and divide

New study explores how protein production goes off script when skin cells turn cancerous

Synthetic molecule appears to reverse Alzheimer's-related neurological damage

Prenatal infection-induced epigenetic modifications may alter brain development in offspring

Mayo Clinic researchers identify genetic promoter that drives lung cancer formation

Scientists identify 'molecular barcode' in blood samples that can predict survival of Ebola patients

MGH researchers identify protein that may protect tumor-initiating cells in breast cancer

Surveillance machinery in cells recognizes and destroys defective genetic material, research shows

Johns Hopkins researchers identify new biological target for treating spinal muscular atrophy

UC researchers uncover obesity-related protein's role in leukemia development

TSRI scientists identify potential therapeutic target for age- or Alzheimer's disease-related memory deficits

New study suggests how risk gene linked to ADHD may work

Scientists discover how motors maneuver cells' intricate roadway system

HD is myopathy as well as neurodegenerative disease, study suggests

TSRI scientists discover precise signaling mechanisms that regulate brain’s motor function

Preconsumption of red wine can prevent short-term vascular injury caused by smoking

Stem-cell-derived gap junction cells could be important therapeutic target for treatment of hereditary deafness

Research reveals new molecular mechanisms of Huntington's disease

Advances in RNA research could pave new way for development of anti-cancer drugs

Researchers identify heart defects in progeria patients that may raise risk of arrhythmias, premature death

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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