Messenger RNA (mRNA) News and Research

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New genomic, proteomic tools yield clues to exercise/diet effects on obesity, metabolic syndrome and diabetes

Applying the latest genomic and proteomic techniques has given researchers new clues for the interaction between exercise and diet, glucose metabolism and improvement in cardiovascular disease (CVD) risk factors.

5 Oct 2004

Phase II trials of the first second-generation antisense cancer drug to be used in patients soon to be underway

Phase II trials of the first second-generation antisense cancer drug to be used in patients are soon to be underway in the wake of a successful Phase I study, which has demonstrated that the new drug blocks its target gene in exactly the way it is designed to do.

28 Sep 2004

New database about a group of genes associated with multidrug resistance in cancerous tumors

Scientists at the National Cancer Institute, have created a database of information about a group of genes associated with multidrug resistance in cancerous tumors.

23 Aug 2004

Receptor for estrogen in ovarian cells has been shown to suppress tumor growth

An important receptor for estrogen in ovarian cells has been shown to suppress tumor growth, according to a new study published in the August 15 issue of the journal Cancer Research.

15 Aug 2004

New gene-silencing technique

A new gene-silencing technique that takes place in the nucleus of human cells, has been demonstrated by researchers at the University of California, San Diego (UCSD) School of Medicine and the VA San Diego Healthcare System.

5 Aug 2004

Protein loss plays role in acute T-cell leukemia

The loss of a key protein (Smad3) in a pathway that helps prevent tumors from forming is specific to one form of childhood leukemia, but not to other pediatric and adult forms of leukemia, according to a new study published in the August 5, 2004, New England Journal of Medicine.

5 Aug 2004

Market research 'World RNAi Markets: Current and Future Outlook'

Gene silencing by RNAi has now been identified as a crucial technology for target validation and therapeutics. By targeting and interfering with messenger RNA (mRNA), RNAi technology blocks the expression of the proteins implicated in disease progression.

19 Jul 2004

DNA left overs, new mechanism for evolution

A team of researchers from the Universitat Autònoma de Barcelona (UAB) has discovered that transposons, small DNA sequences that travel through the genomes, can silence the genes adjacent to them by inducing a molecule called antisense RNA.

16 Jul 2004

Molecular mechanisms behind XsalF's anterior specifying activity

Embryologists have long been interested in working out the means by which this regionalization is achieved, and for years the dominant theory has involved a two-step mechanism in which neural tissues are first induced lengthwise down the entire body axis, followed by a transformation step where a second signal specifies the posterior identities of the neural tissue

13 Jul 2004

Chemoradioimmunotherapy for advanced breast cancer

A successful, and novel, technique to kill metastatic breast cancer cells by circumventing their chemo- and radioresistant mechanisms was by presented by Dr John Giannios, Head of Radiotherapeutic Cancer Research at the IASO Hospital

8 Jul 2004

Combining targeted immunotherapy with chemotherapy and radiation therapy to successfully kill metastatic tumour cells

A successful, and novel, technique to kill metastatic breast cancer cells by circumventing their chemo and radioresistant mechanisms was by presented by Dr. John Giannios, Head of Radiotherapeutic Cancer Research at the IASO Hospital

7 Jul 2004

Three-dimensional cryo-electron microscope may help guide the design of new antibiotics

Understanding the last step of protein synthesis – the basic process of translating DNA into its final protein product – just became more clear both literally and figuratively.

1 Jul 2004

A gene involved in the adhesion of cells is less active in breast tumors with a poor prognosis than those that are less aggressive

Physicians may be able to make early decisions on the best treatment for breast cancer, thanks to research published in Breast Cancer Research today.

28 Jun 2004

Discovery of gene that causes a rare juvenile-onset form of amyotrophic lateral sclerosis (ALS)

The discovery of the Senataxin gene, on chromosome 9q34, may provide clues to the mechanisms of related brain disorders. The study appears in the June 2004 issue of the American Journal of Human Genetics.

28 Jun 2004

Muscular German boy sheds new light on muscle development and genetics

By studying the genetic make up of a German boy born with unusually well developed muscles, an international research team has discovered the first evidence that the gene whose loss makes "mighty mice" also controls muscle growth in people.

24 Jun 2004

Microchip to track genetic signature of cancer and normal tissue

MicroRNAs (miRNAs), tiny pieces of genetic material that can serve as stop signs for gene expression and protein synthesis, are thought to be important in the development of cancer.

23 Jun 2004

Discovery could pave the way to smallpox Immunity

A team of scientists led by a Howard Hughes Medical Institute (HHMI) international research scholar has discovered the immune system mechanism that causes some mice to be more susceptible to mousepox than others.

9 Jun 2004

Four critical components of cells' protein-building machine don't do what scientists had long assumed

In the hunt for these details, scientists have focused on four RNA building blocks, or nucleotides, deep within the machine that are identical in every species, from bacteria to humans. Because they sit where the protein chain is actually built, these "universally conserved" nucleotides in the ribosome were thought to help that process.

28 May 2004

Randomness in gene expression to lead to differences in people that are genetically identical

Experiments by Howard Hughes Medical Institute (HHMI) researchers have revealed it might be possible for randomness in gene expression to lead to differences in cells — or people, for that matter — that are genetically identical.

27 May 2004

Finding overturns long held ideas about how cells build proteins

Writing in the May 28 issue of Cell, Johns Hopkins researchers report that four critical components of cells' protein-building machine don't do what scientists had long assumed.