Metabolic Disorders News and Research

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High-fat diet during lactation alters RNA activity in breast milk, research suggests

New research suggests that following a high-fat diet during lactation-;regardless of diet during pregnancy-;alters RNA activity in breast milk. The changes in genetic material may increase the risk of metabolic disorders such as type 2 diabetes in offspring. The article is published ahead of print in Physiological Genomics.

21 Nov 2017

Anti-diabetic drug can enhance repair of UV-induced DNA damage in cells of ‘Moon children’

The destructive force of UV radiation on DNA molecules is only fully visible, when repair mechanisms fail: patients with the rare genetic disease Xeroderma pigmentosum - also known as 'Moon children' - develop inflammations upon exposure to only small amounts of sunlight, rough-surfaced growths and eventually skin cancer occurs often in early age.

21 Nov 2017

Preclinical study shows clear path toward effective treatment for rare bone disease

Researchers at Sanford Burnham Prebys Medical Discovery Institute have led a preclinical study demonstrating that the drug palovarotene suppresses the formation of bony tumors (osteochondromas) in models of multiple hereditary exostoses (MHE).

20 Nov 2017

Drug used to prevent and treat malaria may also be effective for Zika virus

A new collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute and UC San Diego School of Medicine has found that a medication used to prevent and treat malaria may also be effective for Zika virus.

17 Nov 2017

Grand Challenges Explorations grant awarded to Tufts University for global health research

Tufts University announced today that it is a Grand Challenges Explorations winner, an initiative funded by the Bill & Melinda Gates Foundation. Charlie Mace, assistant professor of chemistry in the School of Arts and Sciences at Tufts University, will pursue research that could potentially revolutionize the way blood samples are analyzed and stored in the field.

14 Nov 2017

Combined effect of gestational diabetes and hypertension leaves both parents at high risk

Research has already shown that women who develop either diabetes or high blood pressure during pregnancy are at risk of getting type 2 diabetes, high blood pressure or heart disease years later.

14 Nov 2017

Scientists identify critical player in Alzheimer's disease pathogenesis

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that a protein called membralin is critical for keeping Alzheimer's disease pathology in check.

14 Nov 2017

New biomarker could lead to early detection of Alzheimer's disease

Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a peptide that could lead to the early detection of Alzheimer's disease (AD).

10 Nov 2017

SBP researchers identify new protective function for brain protein genetically linked to Alzheimer's

Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a new protective function for a brain protein genetically linked to Alzheimer's. The findings, published in the Journal of Experimental Medicine, could inform novel treatment strategies.

7 Nov 2017

Study elucidates how obesity makes breast cancer more aggressive

Obesity leads to the release of cytokines into the bloodstream which impact the metabolism of breast cancer cells, making them more aggressive as a result. Scientists from Helmholtz Zentrum München, Technische Universität München, and Heidelberg University Hospital report on this in 'Cell Metabolism'. The team has already been able to halt this mechanism with an antibody treatment.

23 Oct 2017

TSRI study offers key insights into possible links between sleep and hunger

A new study from scientists on the Florida campus of The Scripps Research Institute offers important insights into possible links between sleep and hunger-;and the benefits of studying the two in tandem.

13 Oct 2017

Crown Bioscience announces availability of new translational models for obesity and diabetes in Europe

Crown Bioscience, a wholly-owned subsidiary of Crown Bioscience International and a global drug discovery and development services company providing translational platforms to advance oncology, inflammation, cardiovascular and metabolic disease research, announces the availability of their proprietary FATZO model in a European based laboratory.

12 Oct 2017

Study provides insights into non-oncogenic addictions of tumors

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego have shown that tumors can ensure a more reliable nutrient supply by eliminating the p62 protein in surrounding stromal tissue.

9 Oct 2017

Unique conference aims at preventing major diseases and extending healthy lifespan

The program for the first assembly of the World Congress on Targeting Metabesity is now available at www.metabesity2017.com. Metabesity refers to the major public health challenges—cardiovascular disease, cancer, dementia, diabetes and the aging process itself—all of which share metabolic roots.

4 Oct 2017

SBP researcher awarded $10.8 million grant to pursue development of new drug for substance abuse

Sanford Burnham Prebys Medical Discovery Institute is pleased to announce the National Institute on Drug Abuse at the National Institutes of Health has awarded Nicholas Cosford, Ph.D., a three-year, $10.8 million grant to pursue the preclinical development of a new class of medicine to treat substance use disorders.

26 Sep 2017

New sickle cell disease poll dispels long-held perceptions of African Americans

Pfizer Inc., the National Newspaper Publishers Association, and scholars from Howard University today announced results from a new national poll designed to deepen understanding and gauge perceptions around sickle cell disease (SCD) among African Americans.

21 Sep 2017

Physical stress in preemies plus separation from mothers may have lasting effects into adulthood

A new study suggests that physiological stress in premature infants combined with separation from their mothers may have lasting effects into adulthood.

20 Sep 2017

A skin patch to get rid of those love handles

Researchers from the Columbia University Medical Center (CUMC) and the University of North Carolina have managed to devise a microneedle skin patch that could locally treat both obesity and diabetes. As of now it has been used to treat mice in the laboratory and shown promising results.

17 Sep 2017

Unfolded protein response could be cause of metabolic disorders, say researchers

The cell's response to unfolded or misfolded proteins could be a cause, rather than a consequence, of metabolic disorders, report researchers at the Medical University of South Carolina in an article published online ahead of print on September 4, 2017 by Nature Structural & Molecular Biology.

4 Sep 2017

Protein intake three times a day could be linked to greater mass, muscle strength in the elderly

Loss of muscle is an inevitable consequence of aging that can lead to frailty, falls or mobility problems. Eating enough protein is one way to remedy it, but it would seem that spreading protein equally among the three daily meals could be linked to greater mass and muscle strength in the elderly.

31 Aug 2017

Metabolic Disorders News and Research

High-fat diet during lactation alters RNA activity in breast milk, research suggests

Anti-diabetic drug can enhance repair of UV-induced DNA damage in cells of ‘Moon children’

Preclinical study shows clear path toward effective treatment for rare bone disease

Drug used to prevent and treat malaria may also be effective for Zika virus

Grand Challenges Explorations grant awarded to Tufts University for global health research

Combined effect of gestational diabetes and hypertension leaves both parents at high risk

Scientists identify critical player in Alzheimer's disease pathogenesis

New biomarker could lead to early detection of Alzheimer's disease

SBP researchers identify new protective function for brain protein genetically linked to Alzheimer's

Study elucidates how obesity makes breast cancer more aggressive

TSRI study offers key insights into possible links between sleep and hunger

Crown Bioscience announces availability of new translational models for obesity and diabetes in Europe

Study provides insights into non-oncogenic addictions of tumors

Unique conference aims at preventing major diseases and extending healthy lifespan

SBP researcher awarded $10.8 million grant to pursue development of new drug for substance abuse

New sickle cell disease poll dispels long-held perceptions of African Americans

Physical stress in preemies plus separation from mothers may have lasting effects into adulthood

A skin patch to get rid of those love handles

Unfolded protein response could be cause of metabolic disorders, say researchers

Protein intake three times a day could be linked to greater mass, muscle strength in the elderly

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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