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Ambrisentan avoids sildenafil drug interaction in PAH patients

Ambrisentan avoids sildenafil drug interaction in PAH patients

Sildenafil may be better given to pulmonary arterial hypertension patients in combination with ambrisentan than with bosentan, study findings suggest. [More]
Missouri S&T researcher comes up with patented breast cancer screening device

Missouri S&T researcher comes up with patented breast cancer screening device

Cancer screening could soon be as simple as giving a urine sample using a patented device developed by a Missouri University of Science and Technology researcher. This week, Wyoming-based Cancer.im Inc., a Viratech Corp. company and social network for cancer patients, survivors and caretakers, announced an agreement with Missouri S&T to commercialize the device. [More]
New way to more efficiently deliver CRISPR/Cas9 therapeutic to mice with Tyrosinemia type I

New way to more efficiently deliver CRISPR/Cas9 therapeutic to mice with Tyrosinemia type I

University of Massachusetts Medical School researchers have found a way to more efficiently delivery a CRISPR/Cas9 therapeutic to adult mice with the metabolic disease Tyrosinemia type I that may also prove to be safer for use in humans. [More]
New technology could help identify, characterize biologically active molecules produced by living cells

New technology could help identify, characterize biologically active molecules produced by living cells

Gene sequencing company Illumina recently made big waves by announcing a new spinoff, Grail, dedicated to building a test for cancer by sequencing tumor DNA fragments found in blood. The company also reported plans for a separate project to identify single cells and tag them for later analysis. [More]
Biomedical innovation in the UK: an interview with Zahid Latif

Biomedical innovation in the UK: an interview with Zahid Latif

The biomedical research base is one of the UK's strengths; over 1500 companies in the Pharmaceuticals and biotechnology area are established in the UK employing over 70,000. [More]
Researchers confirm that cranberry extract helps fight UTIs in breastfed children under age one

Researchers confirm that cranberry extract helps fight UTIs in breastfed children under age one

Researchers from the universities of Granada (Spain) and Kvopio (Finland) have confirmed that cranberry extract helps fighting urinary tract infections (UTIs) in breastfed babies under one year of age. [More]
Study reveals how imbalance of omega-3 fatty acids affects brain development in offspring

Study reveals how imbalance of omega-3 fatty acids affects brain development in offspring

Researchers at Tohoku University's School of Medicine have found an explanation for the correlation between eating fish during pregnancy, and the health of the baby's brain. [More]
Study opens new door on the causes of vision issues in astronauts

Study opens new door on the causes of vision issues in astronauts

Just when you think you've seen it all, our eyes look to be victims of a low-gravity environments, too. According to new research published in the January 2016 issue of The FASEB Journal, two significant genetic differences in enzymes that direct the one-carbon pathway of metabolism can affect astronaut vision. [More]
People with low sunlight exposure and vitamin D deficiency at greater risk of developing leukemia

People with low sunlight exposure and vitamin D deficiency at greater risk of developing leukemia

Epidemiologists at University of California, San Diego School of Medicine report that persons residing at higher latitudes, with lower sunlight/ultraviolet B (UVB) exposure and greater prevalence of vitamin D deficiency, are at least two times at greater risk of developing leukemia than equatorial populations. [More]
Insulin-producing cells' mitochondria may represent useful therapeutic target in type 2 diabetes

Insulin-producing cells' mitochondria may represent useful therapeutic target in type 2 diabetes

Factors in the blood from calorie-restricted rats can modify energy-producing mitochondria within the insulin-producing cells that regulate blood sugar levels, new research shows. This has a positive impact on glucose-stimulated insulin secretion and protects cells from fatty acid and glucose toxicity. [More]

Scientists seek development of advanced tools to explore microbiomes

In October, an interdisciplinary group of scientists proposed forming a Unified Microbiome Initiative (UMI) to explore the world of microorganisms that are central to life on Earth and yet largely remain a mystery. An article in the journal ACS Nano describes the tools scientists will need to understand how microbes interact with each other and with us. [More]
ORNL's cell-free protein synthesis system can help save lives of soldiers injured in remote locations

ORNL's cell-free protein synthesis system can help save lives of soldiers injured in remote locations

Lives of soldiers and others injured in remote locations could be saved with a cell-free protein synthesis system developed at the Department of Energy's Oak Ridge National Laboratory. [More]
Study on how immune systems of astronauts respond to seasonal flu vaccine

Study on how immune systems of astronauts respond to seasonal flu vaccine

Every year, as influenza season - and flu shot season--rolls around, medical experts weigh in on just how effective it will be against that year's particular strain. What if that equation could take into account a person's own immune response? [More]
Identifying new mechanism for aspirin in cancer prevention

Identifying new mechanism for aspirin in cancer prevention

Aspirin has been shown to decrease the risk of colorectal cancer and possibly other cancers. However, the risk of side effects, including in some cases severe gastrointestinal bleeding, makes it necessary to better understand the mechanisms by which aspirin acts at low doses before recommending it more generally as a preventative, says Cornelia Ulrich, PhD, Senior Director of Population Sciences at Huntsman Cancer Institute in Salt Lake City. [More]
Study may lead to development of highly accurate screening test for early-stage ovarian cancer

Study may lead to development of highly accurate screening test for early-stage ovarian cancer

Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer. [More]
Changes in cellular metabolites regulate earliest stages of embryonic stem cell development

Changes in cellular metabolites regulate earliest stages of embryonic stem cell development

Changes in cellular metabolites have been shown to regulate embryonic stem cell development at the earliest stages of life. Metabolites are simple compounds generated during life-sustaining chemical activities in cells. [More]
Helmholtz Centre for Infection Research scientists identify promising antitumor agent

Helmholtz Centre for Infection Research scientists identify promising antitumor agent

Support comes out of the ground: Scientists from the Helmholtz Centre for Infection Research in Germany have identified a terrestrial myxobacterium as a promising source for the bengamide class of natural products, which were originally thought to be secondary metabolites of marine sponges only. [More]
New computational method helps predict adverse drug reaction better than traditional computing methods

New computational method helps predict adverse drug reaction better than traditional computing methods

A new integrated computational method helps predicting adverse drug reaction--which are often lethal--more reliably than with traditional computing methods. This improved ability to foresee the possible adverse effects of drugs may entail saving many lives in the future. [More]
Denator forms a new Scientific Advisory Board

Denator forms a new Scientific Advisory Board

Denator AB has announced that a new external expert advisory board has been formed. Karsten Fjärstedt, recently appointed as CEO comments, “It is a great honor for me to be entrusted to lead Denator forward in this new phase of development. With a pipeline of new exciting business opportunities and a strong Scientific Advisory Board (SAB) I am looking forward to realizing the full potential of the company technology”. [More]

Radiocarbon method proves Cameroon’s environment is contaminated with synthetic opioid

Tramadol, a synthetic opioid component of the painkiller tramal, was surprisingly identified in 2013 as a natural product of Sarcocephalus latifolia, a tree found in Cameroon. [More]
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