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Metabolomics and NMR

Metabolomics and NMR

Bruker has been involved in the Phenome Center network since its beginning. Several years ago, the whole visionary concept of a global phenome network was actually born with Professor Jeremy Nicholson and Bruker BioSpin has been part of it since the early stages. [More]
Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Metastatic pancreatic cancer -- cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths -- changes its metabolism and is "reprogrammed" for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics. [More]
Researchers develop novel tests that could improve treatment for heart failure patients

Researchers develop novel tests that could improve treatment for heart failure patients

For the first time, researchers have developed tests that could improve treatment for heart failure patients by diagnosing the condition with greater accuracy, as well as by detecting the onset of congestive heart failure earlier. [More]
UTA chemists developing new synthetic methods to produce compounds for drug discovery

UTA chemists developing new synthetic methods to produce compounds for drug discovery

Chemists at The University of Texas at Arlington are developing new methods to synthesize groups of chemical compounds to provide faster, less expensive routes to produce the compounds for subsequent use in medical drug discovery and development. [More]
Nexmos, Base Pair Biotechnologies create new class of DNA-aptamer based oxidation inhibitors

Nexmos, Base Pair Biotechnologies create new class of DNA-aptamer based oxidation inhibitors

Base Pair Biotechnologies, Inc., The Aptamer Discovery Company, and Nexmos, Inc., the Aptamer Application R&D Company, announce the creation of a new class of DNA-aptamer based oxidation inhibitors. [More]
Researchers creating computer model to track circadian clock

Researchers creating computer model to track circadian clock

Biology dictates that DNA creates proteins which create - among other things - metabolites, the outputs of metabolism. [More]
Sphere Medical launches next generation Proxima for bedside blood gas and glucose analysis

Sphere Medical launches next generation Proxima for bedside blood gas and glucose analysis

Sphere Medical, an innovative company in critical care monitoring and diagnostics equipment, has launched its next generation CE-marked Proxima system. [More]
Researchers use worms as model system to study how gut microbiome influences disease

Researchers use worms as model system to study how gut microbiome influences disease

The billions of microorganisms living within the human digestive tract appear to play a significant role in health and disease, notably metabolic syndrome, autoimmune disorders and diabetes - but how these organisms do so is not well understood. [More]
U-M awarded NIH grant to investigate molecular changes that occur during and after physical activity

U-M awarded NIH grant to investigate molecular changes that occur during and after physical activity

The University of Michigan was recently awarded $8.2 million from the National Institutes of Health to investigate the molecular changes that occur during and after physical activity. [More]
Japanese researchers discover that 2-aminobutyric acid can effectively raise antioxidant levels

Japanese researchers discover that 2-aminobutyric acid can effectively raise antioxidant levels

A Japanese research team has become the first in the world to discover that 2-aminobutyric acid (2-AB) is closely involved in the metabolic regulation of the antioxidant glutathione, and that it can effectively raise levels of glutathione in the body when ingested. [More]
Antioxidant levels could be boosted with newly-found amino acid function

Antioxidant levels could be boosted with newly-found amino acid function

A Japanese research team has become the first in the world to discover that 2-aminobutyric acid (2-AB) is closely involved in the metabolic regulation of the antioxidant glutathione, and that it can effectively raise levels of glutathione in the body when ingested. The findings were published in the online version of Scientific Reports on November 9. [More]
Study detects biomarkers from secondhand marijuana smoke exposure in children

Study detects biomarkers from secondhand marijuana smoke exposure in children

Relaxing with a joint around children is not very wise. Not only do youngsters inhale harmful secondary smoke in the process, but the psychoactive chemicals in the drug are taken up by their bodies as well. [More]
Researchers identify metabolite that promotes epithelial-mesenchymal transition of colorectal cancer cells

Researchers identify metabolite that promotes epithelial-mesenchymal transition of colorectal cancer cells

Osaka University researchers revealed that the metabolite D-2-hydroxyglurate (D-2HG) promotes epithelial-mesenchymal transition of colorectal cancer cells, leading them to develop features of lower adherence to neighboring cells, increased invasiveness, and greater likelihood of metastatic spread. [More]
New global network to explore link between genes and environmental factors to tackle health challenges

New global network to explore link between genes and environmental factors to tackle health challenges

A new global network linking leading research centres across the world has launched today to tackle some of the most pressing global health challenges of our time such as autism, cancer, diabetes and dementia. [More]
New urine test could potentially reduce fatigue-related mistakes

New urine test could potentially reduce fatigue-related mistakes

Doctors, pilots, air traffic controllers and bus drivers have at least one thing in common — if they're exhausted at work, they could be putting lives at risk. But the development of a new urine test, reported in the ACS journal Analytical Chemistry, could help monitor just how weary they are. [More]
Researchers develop virtual liver model to better understand metabolism of non-prescription painkiller

Researchers develop virtual liver model to better understand metabolism of non-prescription painkiller

Researchers at Indiana University's Biocomplexity Institute have developed a virtual model of the human liver to better understand how the organ metabolizes acetaminophen, a common non-prescription painkiller and fever-reducer used in over-the-counter drugs such as Tylenol. [More]
TUM scientists explore link between gastrointestinal microbiota and dietary fats

TUM scientists explore link between gastrointestinal microbiota and dietary fats

Gut bacteria play a little-understood role in the body’s energy balance, which is influenced by diet. However, the crucial nutritional components are unknown. A team at the Technical University of Munich was able to demonstrate for the very first time that mice without gastrointestinal microbiota grow obese when fed with dietary fat from plant sources, but not from animal sources. [More]
New research provides insights into how gut microbes drive host gene expression

New research provides insights into how gut microbes drive host gene expression

In our guts, and in the guts of all animals, resides a robust ecosystem of microbes known as the microbiome. Consisting of trillions of organisms — bacteria, fungi and viruses — the microbiome is essential for host health, providing important services ranging from nutrient processing to immune system development and maintenance. [More]
Stuttering linked to changes in speech and language-based brain circuits

Stuttering linked to changes in speech and language-based brain circuits

Researchers at Children's Hospital Los Angeles have conducted the first study of its kind, using proton magnetic resonance spectroscopy (MRS) to look at brain regions in both adults and children who stutter. [More]
Researchers develop new rapid diagnostic test for cocaine in urine and oral fluid

Researchers develop new rapid diagnostic test for cocaine in urine and oral fluid

Academics in the University of Surrey's Department of Chemistry have developed a new diagnostic test for cocaine and benzoylecgonine (the main metabolite for cocaine) in urine and oral fluid. [More]
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