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Study detects biomarkers from secondhand marijuana smoke exposure in children

Study detects biomarkers from secondhand marijuana smoke exposure in children

Relaxing with a joint around children is not very wise. Not only do youngsters inhale harmful secondary smoke in the process, but the psychoactive chemicals in the drug are taken up by their bodies as well. [More]
Researchers identify metabolite that promotes epithelial-mesenchymal transition of colorectal cancer cells

Researchers identify metabolite that promotes epithelial-mesenchymal transition of colorectal cancer cells

Osaka University researchers revealed that the metabolite D-2-hydroxyglurate (D-2HG) promotes epithelial-mesenchymal transition of colorectal cancer cells, leading them to develop features of lower adherence to neighboring cells, increased invasiveness, and greater likelihood of metastatic spread. [More]
New global network to explore link between genes and environmental factors to tackle health challenges

New global network to explore link between genes and environmental factors to tackle health challenges

A new global network linking leading research centres across the world has launched today to tackle some of the most pressing global health challenges of our time such as autism, cancer, diabetes and dementia. [More]
New urine test could potentially reduce fatigue-related mistakes

New urine test could potentially reduce fatigue-related mistakes

Doctors, pilots, air traffic controllers and bus drivers have at least one thing in common — if they're exhausted at work, they could be putting lives at risk. But the development of a new urine test, reported in the ACS journal Analytical Chemistry, could help monitor just how weary they are. [More]
Researchers develop virtual liver model to better understand metabolism of non-prescription painkiller

Researchers develop virtual liver model to better understand metabolism of non-prescription painkiller

Researchers at Indiana University's Biocomplexity Institute have developed a virtual model of the human liver to better understand how the organ metabolizes acetaminophen, a common non-prescription painkiller and fever-reducer used in over-the-counter drugs such as Tylenol. [More]
TUM scientists explore link between gastrointestinal microbiota and dietary fats

TUM scientists explore link between gastrointestinal microbiota and dietary fats

Gut bacteria play a little-understood role in the body’s energy balance, which is influenced by diet. However, the crucial nutritional components are unknown. A team at the Technical University of Munich was able to demonstrate for the very first time that mice without gastrointestinal microbiota grow obese when fed with dietary fat from plant sources, but not from animal sources. [More]
New research provides insights into how gut microbes drive host gene expression

New research provides insights into how gut microbes drive host gene expression

In our guts, and in the guts of all animals, resides a robust ecosystem of microbes known as the microbiome. Consisting of trillions of organisms — bacteria, fungi and viruses — the microbiome is essential for host health, providing important services ranging from nutrient processing to immune system development and maintenance. [More]
Stuttering linked to changes in speech and language-based brain circuits

Stuttering linked to changes in speech and language-based brain circuits

Researchers at Children's Hospital Los Angeles have conducted the first study of its kind, using proton magnetic resonance spectroscopy (MRS) to look at brain regions in both adults and children who stutter. [More]
Researchers develop new rapid diagnostic test for cocaine in urine and oral fluid

Researchers develop new rapid diagnostic test for cocaine in urine and oral fluid

Academics in the University of Surrey's Department of Chemistry have developed a new diagnostic test for cocaine and benzoylecgonine (the main metabolite for cocaine) in urine and oral fluid. [More]
De-risking drug development free webinar from Envigo

De-risking drug development free webinar from Envigo

De-risking represents a relatively new but developing strategy designed to quickly assess if a new drug has a liability. Knowing your compound’s risk for drug-to-drug interactions (DDI), drug induced liver injury (DILI) and metabolites in safety testing (MIST) early on in drug development, leads to greater confidence and added value on your molecule’s journey to market. [More]
New bioinformatic framework identifies protein that plays key role in diabetic kidney disease

New bioinformatic framework identifies protein that plays key role in diabetic kidney disease

A new bioinformatic framework developed by researchers at University of California San Diego School of Medicine has identified key proteins significantly altered at the gene-expression level in biopsied tissue from patients with diabetic kidney disease, a result that may reveal new therapeutic targets. [More]
Retinitis pigmentosa can be slowed by reprogramming metabolism of photoreceptors, study shows

Retinitis pigmentosa can be slowed by reprogramming metabolism of photoreceptors, study shows

Columbia University Medical Center researchers have demonstrated that vision loss associated with a form of retinitis pigmentosa (RP) can be slowed dramatically by reprogramming the metabolism of photoreceptors, or light sensors, in the retina. [More]
Scientists discover new mechanism responsible for regulation of glucose metabolism

Scientists discover new mechanism responsible for regulation of glucose metabolism

Diabetes mellitus is a chronic disease that has become increasingly prevalent in the population: More than six million people are affected by the disease alone in Germany. [More]
Researchers shed light on how success of gut microbiome treatments may depend on genetics

Researchers shed light on how success of gut microbiome treatments may depend on genetics

Our gut microbiomes--the bacteria that live in our digestive tract--play major roles in our health. Scientists around the world are studying therapies that manipulate the microbiome, including probiotics (such as live bacterial cultures in yogurt), prebiotics (edible fibers meant to promote beneficial bacteria), antibiotics and transplants of microbes from healthy people. [More]
Researchers develop new blood test that can accurately diagnose concussions

Researchers develop new blood test that can accurately diagnose concussions

Scientists from Children's Health Research Institute, a program of Lawson Health Research Institute, and Western University have developed a new blood test that identifies with greater than 90 per cent certainty whether or not an adolescent athlete has suffered a concussion. [More]
Study shows metabolite concentration can be controlled in bioreactors using OPC enabled BioProfile FLEX analyser

Study shows metabolite concentration can be controlled in bioreactors using OPC enabled BioProfile FLEX analyser

Current initiatives within the biopharmaceutical industry to adopt PAT (Process Analytical Technology) approaches in manufacturing, include activities in early process development. [More]
Omega-3 fatty acids could promote clearance of metabolites in the brain, research shows

Omega-3 fatty acids could promote clearance of metabolites in the brain, research shows

New research published online in The FASEB Journal suggests that omega-3 polyunsaturated fatty acids, which are found in fish oil, could improve the function of the glymphatic system, which facilitates the clearance of waste from the brain, and promote the clearance of metabolites including amyloid-β peptides, a primary culprit in Alzheimer's disease. [More]
WSU researchers identify potential new diagnostic tool for early detection of colorectal cancer

WSU researchers identify potential new diagnostic tool for early detection of colorectal cancer

Scientists at Washington State University and Johns Hopkins Medical School have discovered a fast, noninvasive method that could lead to the early diagnosis of colorectal cancer. [More]
Benefit and harm of tandem mass spectrometry screening for tyrosinaemia type 1 remain unclear

Benefit and harm of tandem mass spectrometry screening for tyrosinaemia type 1 remain unclear

Tyrosinaemia type 1 is a rare, hereditary metabolic disease that, if left untreated, can already lead to serious liver and kidney damage in infancy. [More]
Choline deficiency in sows during pregnancy impacts nutrient composition of milk

Choline deficiency in sows during pregnancy impacts nutrient composition of milk

Choline is an essential nutrient that is used by the body in a number of ways. However, nearly 90 percent of adults do not get the recommended amount in their diets. [More]
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