Metastasis News and Research RSS Feed - Metastasis News and Research

Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases
Vitamin D and androgen receptor-targeted therapy may help treat TNBC

Vitamin D and androgen receptor-targeted therapy may help treat TNBC

A recent study by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine revealed that triple-negative breast cancer (TNBC), which has generally been unresponsive to hormone receptor-targeted treatments, can indeed be treated using vitamin D and androgen receptor-targeted therapy. [More]
Cornell researchers develop nanoparticle-based drug delivery mechanism for combination cancer therapy

Cornell researchers develop nanoparticle-based drug delivery mechanism for combination cancer therapy

A team of researchers from Cornell University in Ithaca, New York demonstrated a drug delivery mechanism that utilizes two independent vehicles, allowing for delivery of chemically and physically dis-tinct agents. [More]
Two-way communication between cancer cells may be key to tumor metastasis

Two-way communication between cancer cells may be key to tumor metastasis

Two-way communication between cancer cells appears to be key to their becoming motile, clustering and spreading through metastasis, according to Rice University scientists. [More]
LIGR-Seq tool opens door to developing new understanding of ncRNA function

LIGR-Seq tool opens door to developing new understanding of ncRNA function

What used to be dismissed by many as "junk DNA" is back with a vengeance as growing data points to the importance of non-coding RNAs (ncRNAs) -- genome's messages that do not code for proteins -- in development and disease. [More]
AstraZeneca, MedImmune to provide update on extensive oncology pipeline at ASCO 2016

AstraZeneca, MedImmune to provide update on extensive oncology pipeline at ASCO 2016

AstraZeneca and its global biologics research and development arm, MedImmune, will provide an update on their extensive oncology pipeline at the annual meeting of the American Society of Clinical Oncology in Chicago, USA, on 3-7 June 2016. [More]
New ultrasound method provides way to measure acoustic-mechanic properties of cells

New ultrasound method provides way to measure acoustic-mechanic properties of cells

In brief, the new method involves exposing cells to ultrasound when they flow through a so-called micro-channel inside a chip. [More]
Researchers reveal new mechanism that helps breast cancer cells engage MDSCs

Researchers reveal new mechanism that helps breast cancer cells engage MDSCs

Not every breast cancer tumor follows the same path to grow. Some tumors have the assistance of myeloid-derived suppressor cells (MDSCs), a diverse type of immune cell involved in the suppression of the body's response against tumors. [More]
Inhibiting autophagy can effectively block tumor cell migration, breast cancer metastasis

Inhibiting autophagy can effectively block tumor cell migration, breast cancer metastasis

Researchers from the University of Chicago have shown that inhibiting autophagy, a self-devouring process used by cells to degrade large intra-cellular cargo, effectively blocks tumor cell migration and breast cancer metastasis in tumor models. [More]
Novel UBC-developed device could soon pave way for improved cancer diagnosis

Novel UBC-developed device could soon pave way for improved cancer diagnosis

A new UBC-developed method to isolate cancer cells that have escaped from a tumour could soon pave the way for improved diagnosis and treatment. [More]
Scientists discover reliable marker to spot CAFs in oral cancer tissues

Scientists discover reliable marker to spot CAFs in oral cancer tissues

For the first time, researchers have identified a reliable marker (PDGFRβ) to detect carcinoma-associated fibroblasts (cells within the tumor that encourage growth and metastasis) (CAFs) in oral cancer tissues. With this discovery, anti-PDGFRβ treatment could soon be combined with existing tumor treatments to provide a more effective cancer therapy. [More]
Patient-specific immunotherapeutic vaccines may improve overall survival of melanoma patients

Patient-specific immunotherapeutic vaccines may improve overall survival of melanoma patients

Two patients with melanoma that had spread to the liver survived for at least 8.5 and 12 years after resection of the hepatic tumor and treatment with patient-specific immunotherapeutic vaccines. [More]
MUSC Hollings Cancer Center receives $8.9 million grant to explore signaling in sphingolipids

MUSC Hollings Cancer Center receives $8.9 million grant to explore signaling in sphingolipids

The Medical University of South Carolina's Hollings Cancer Center received an $8.9 million grant from the National Cancer Institute designed to foster collaboration across clinical and laboratory research for the study of signaling in sphingolipids, a class of lipids known to be involved in the growth of solid tumor cancers. [More]
Importance of understanding ovarian cancer on molecular level

Importance of understanding ovarian cancer on molecular level

Nearly 70 percent of ovarian cancer cases are detected after metastasis, which is the development of secondary malignant growths distant from the primary site of cancer. [More]
Controlling cholesterol metabolism could help reduce pancreatic cancer spread

Controlling cholesterol metabolism could help reduce pancreatic cancer spread

Researchers have shown how controlling cholesterol metabolism in pancreatic cancer cells reduces metastasis, pointing to a potential new treatment using drugs previously developed for atherosclerosis. [More]
Combination of existing chemotherapy drugs can reduce breast cancer stem cells, improve survival

Combination of existing chemotherapy drugs can reduce breast cancer stem cells, improve survival

Two existing chemotherapy drugs appear to be a powerful pair in targeting errant stem cells that are making breast cancer and enabling its spread and recurrence, scientists report. [More]
Curve along edge of tumor may play major role in cancer cell metastasis

Curve along edge of tumor may play major role in cancer cell metastasis

Only a few cells in a cancerous tumor are able to break away and spread to other parts of the body, but the curve along the edge of the tumor may play a large role in activating these tumor-seeding cells, according to a new University of Illinois study. [More]
New research reveals sliding ability of cancer cells that helps in tumor spread

New research reveals sliding ability of cancer cells that helps in tumor spread

Metas­tasis. The very word evokes fear. Defined as the spread of cancer cells from one part of the body to another, metastasis is the cause of approximately 90 percent of deaths among cancer patients. How does metastasis come about? And can we stop it?
New research from a team led by Northeastern's Anand Asthagiri, associate professor of bioengineering and chemical engineering, helps to answer those questions. It provides an astonishing look at the biophysical properties that permit breast cancer cells to "slide" by obsta­les and travel out of their primary tumor toward a blood vessel that will carry them to a new site. [More]
Study reveals surprising results that may impair future therapeutic approaches in TGF-beta pathway

Study reveals surprising results that may impair future therapeutic approaches in TGF-beta pathway

Researchers at Helmholtz Zentrum München describe how breast cancer cells challenged with a small-molecule inhibitor targeting specific invasive properties switch to an alternative mode-of-action, rendering them even more aggressive. The results may impair future therapeutic approaches in the TGF-beta pathway and are published in the journal 'Oncotarget'. [More]
Novel function of PLK1 gene in prostate cancer metastasis

Novel function of PLK1 gene in prostate cancer metastasis

Researchers at VCU Massey Cancer Center have uncovered a novel function of the gene PLK1 (polo-like kinase 1) that helps prostate cancer cells metastasize (spread) to other parts of the body. This mechanism highlights new potential targets for cancer therapies and challenges the previous understanding of PLK1's role in cancer growth and progression. [More]
Researchers find new insights on disease stages for gastric cancer patients

Researchers find new insights on disease stages for gastric cancer patients

Diagnosis of gastric cancer in the early stages is difficult because of the lack of simple and cheap methods of inspection and specific markers of gastric cancer while the symptoms of the disease are vague and tend to overlap with other common and benign conditions. Better tumor characterization and more individualized treatment planning can be expected only with the implementation of better diagnostic tools combined with advances in molecular and genetic analysis. [More]
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