Metastasis News and Research RSS Feed - Metastasis News and Research

Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases
Importance of understanding ovarian cancer on molecular level

Importance of understanding ovarian cancer on molecular level

Nearly 70 percent of ovarian cancer cases are detected after metastasis, which is the development of secondary malignant growths distant from the primary site of cancer. [More]
Controlling cholesterol metabolism could help reduce pancreatic cancer spread

Controlling cholesterol metabolism could help reduce pancreatic cancer spread

Researchers have shown how controlling cholesterol metabolism in pancreatic cancer cells reduces metastasis, pointing to a potential new treatment using drugs previously developed for atherosclerosis. [More]
Combination of existing chemotherapy drugs can reduce breast cancer stem cells, improve survival

Combination of existing chemotherapy drugs can reduce breast cancer stem cells, improve survival

Two existing chemotherapy drugs appear to be a powerful pair in targeting errant stem cells that are making breast cancer and enabling its spread and recurrence, scientists report. [More]
Curve along edge of tumor may play major role in cancer cell metastasis

Curve along edge of tumor may play major role in cancer cell metastasis

Only a few cells in a cancerous tumor are able to break away and spread to other parts of the body, but the curve along the edge of the tumor may play a large role in activating these tumor-seeding cells, according to a new University of Illinois study. [More]
New research reveals sliding ability of cancer cells that helps in tumor spread

New research reveals sliding ability of cancer cells that helps in tumor spread

Metas­tasis. The very word evokes fear. Defined as the spread of cancer cells from one part of the body to another, metastasis is the cause of approximately 90 percent of deaths among cancer patients. How does metastasis come about? And can we stop it?
New research from a team led by Northeastern's Anand Asthagiri, associate professor of bioengineering and chemical engineering, helps to answer those questions. It provides an astonishing look at the biophysical properties that permit breast cancer cells to "slide" by obsta­les and travel out of their primary tumor toward a blood vessel that will carry them to a new site. [More]
Study reveals surprising results that may impair future therapeutic approaches in TGF-beta pathway

Study reveals surprising results that may impair future therapeutic approaches in TGF-beta pathway

Researchers at Helmholtz Zentrum München describe how breast cancer cells challenged with a small-molecule inhibitor targeting specific invasive properties switch to an alternative mode-of-action, rendering them even more aggressive. The results may impair future therapeutic approaches in the TGF-beta pathway and are published in the journal 'Oncotarget'. [More]
Novel function of PLK1 gene in prostate cancer metastasis

Novel function of PLK1 gene in prostate cancer metastasis

Researchers at VCU Massey Cancer Center have uncovered a novel function of the gene PLK1 (polo-like kinase 1) that helps prostate cancer cells metastasize (spread) to other parts of the body. This mechanism highlights new potential targets for cancer therapies and challenges the previous understanding of PLK1's role in cancer growth and progression. [More]
Researchers find new insights on disease stages for gastric cancer patients

Researchers find new insights on disease stages for gastric cancer patients

Diagnosis of gastric cancer in the early stages is difficult because of the lack of simple and cheap methods of inspection and specific markers of gastric cancer while the symptoms of the disease are vague and tend to overlap with other common and benign conditions. Better tumor characterization and more individualized treatment planning can be expected only with the implementation of better diagnostic tools combined with advances in molecular and genetic analysis. [More]
Inhibiting adrenaline receptors reduces breast cancer brain metastases

Inhibiting adrenaline receptors reduces breast cancer brain metastases

While we look to invent new medicines to treat cancer, a parallel approach to repurpose existing medicines may be highly effective. Stress, mediated by adrenaline, has been suspected to promote cancer growth and this research study shows that by blocking adrenaline receptors in breast cancers, they are less successful in spreading to and growing in the brain. [More]
Newly developed implantable device can deliver chemotherapy drugs directly to pancreatic tumors

Newly developed implantable device can deliver chemotherapy drugs directly to pancreatic tumors

Pancreatic cancer is the third leading cause of cancer deaths in the United States, in part because it is very difficult for chemotherapy drugs to reach the pancreas, which is located deep within the abdomen. [More]
Scientists reveal mechanism involved in regulation of lymphangiogenesis

Scientists reveal mechanism involved in regulation of lymphangiogenesis

After an injury to tissues, such as in organ transplantation, the body grows new lymphatic vessels in a process known as lymphangiogenesis. A new study in Nature Communications reveals a mechanism involved in the regulation of this process, specifically in corneal transplants and infectious eye disease. [More]
High levels of COMP protein may lead to worse breast cancer prognosis

High levels of COMP protein may lead to worse breast cancer prognosis

Research from Lund University in Sweden shows that the protein COMP, which mainly exists in cartilage, can also be found in breast cancer tumours in patients with a poor prognosis. Studies on mice also showed that COMP contributed to the development and metastasis of the breast cancer. [More]
Moffitt study reports that liver metastases have different sensitivities to radiation therapy

Moffitt study reports that liver metastases have different sensitivities to radiation therapy

Radiation is a commonly used therapeutic option to treat liver metastases, with the majority of tumors maintained under control after one year. However, some patients do not respond as well to radiation treatment, and the factors that predict patient outcomes are unclear. Moffitt Cancer Center researchers report that liver metastases have different sensitivities to radiation therapy based on the location of the primary tumor. [More]
Study assesses risk factors for metastases in prostate cancer patients on active surveillance

Study assesses risk factors for metastases in prostate cancer patients on active surveillance

Radical treatment such as surgery and radiation for localized prostate cancer may cause significant side effects. Active surveillance is increasingly accepted as an option for treating patients with clinically insignificant disease to maintain their quality of life. [More]
Metabolic pathway activates cell signaling protein to promote breast cancer metastasis

Metabolic pathway activates cell signaling protein to promote breast cancer metastasis

A metabolic pathway that is up-regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biology. [More]
Novel metabolic pathways help cancer cells thrive under certain conditions

Novel metabolic pathways help cancer cells thrive under certain conditions

Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) have identified a novel metabolic pathway that helps cancer cells thrive in conditions that are lethal to normal cells. [More]
Blocking blood supply of small cell lung cancer tumors may help delay cancer relapse

Blocking blood supply of small cell lung cancer tumors may help delay cancer relapse

A study by researchers at Marshall University Joan C. Edwards School of Medicine has found that blocking the blood supply of small cell lung cancer tumors may help reduce their growth and delay the regrowth process after treatment. Small cell lung cancer is considered the most lethal of all lung cancers. [More]
Aged tumor cells in melanoma behave in a different way than younger tumor cells

Aged tumor cells in melanoma behave in a different way than younger tumor cells

Cancer risk increases with one's age as accumulated damage to our cells and chronic inflammation occur over time. Now, an international team of scientists led by The Wistar Institute have shown that aged tumor cells in melanoma behave differently than younger tumor cells, according to study results published in the journal Nature. [More]
Low-oxygen conditions spur growth of breast cancer stem cells

Low-oxygen conditions spur growth of breast cancer stem cells

Working with human breast cancer cells and mice, scientists at The Johns Hopkins University say new experiments explain how certain cancer stem cells thrive in low oxygen conditions. Proliferation of such cells, which tend to resist chemotherapy and help tumors spread, are considered a major roadblock to successful cancer treatment. [More]
Japanese scientists decode sugar molecule linked to muscular dystrophy

Japanese scientists decode sugar molecule linked to muscular dystrophy

A group of Japanese scientists have succeeded in decoding a sugar molecule and clarifying a mechanism linked to muscular dystrophy. Their discovery has potential implications for muscular dystrophy treatment. The results of their research were published in the journal Cell Reports on February 25, 2016 EST. [More]
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