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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases
New orthotopic model recapitulates more closely metastatic steps in Ewing sarcoma

New orthotopic model recapitulates more closely metastatic steps in Ewing sarcoma

The Sarcoma research group of Bellvitge Biomedical Research Institute, led by Dr. Òscar Martínez-Tirado, has developed a modified version of an orthotopic model that allows researchers to recreate more closely the metastatic steps in Ewing sarcoma (ES), the second most common bone tumor in children and adolescents. [More]
NEJM publishes MINDACT trial results

NEJM publishes MINDACT trial results

Agendia, Inc., a world leader in personalized medicine and molecular cancer diagnostics, announces the peer-reviewed publication of the primary outcome results of the Microarray In Node-negative and 1 to 3 positive lymph node Disease may Avoid ChemoTherapy (MINDACT) clinical trial in the prestigious New England Journal of Medicine (NEJM). (i, iii, iv) The publication demonstrates that 46% of breast cancer patients considered for chemotherapy, whose tumors are classified MammaPrint Low Risk, have excellent survival without chemotherapy, and can thus be candidates to avoid this toxic therapy. [More]
Newly-developed epigenetic test can be used to identify tumors responsible for metastasis in cancer patient

Newly-developed epigenetic test can be used to identify tumors responsible for metastasis in cancer patient

In patients with cancer, initial diagnosis most often includes the detection of the primary or original tumor and the presence or absence of metastases, ie cells from the original tumor that have escaped from their original location and are growing into other tissues of the patient. [More]
Study shows lymph node stage may have clinical importance among NSCLC patients with M1a disease

Study shows lymph node stage may have clinical importance among NSCLC patients with M1a disease

Analysis of a large non-small cell lung cancer (NSCLC) patient cohort with stage IV M1a disease identified lymph node staging as having clinical significance and an impact on prognosis. [More]
Tel Aviv University researchers unravel how melanoma spreads to distant organs

Tel Aviv University researchers unravel how melanoma spreads to distant organs

In a landmark discovery, researchers at Tel Aviv University have unraveled the metastatic mechanism of melanoma, the most aggressive of all skin cancers. [More]
Fruit fly models may help scientists understand underlying mechanism of HPV-induced cancer

Fruit fly models may help scientists understand underlying mechanism of HPV-induced cancer

Human papillomavirus (HPV) is one of the most common sexually transmitted infections in the United States and has been identified as a primary cause of cervical cancer in women. [More]
Cold plasma could help bones heal faster, study shows

Cold plasma could help bones heal faster, study shows

Cold plasma looks like the glow from the "Star Wars" blue light saber but this beam of energy, made of electrons that change polarity at micro-second or nanosecond speeds, could help bones heal faster, according to a study published August 11th in the Journal of Tissue Engineering and Regenerative Medicine. [More]
Scientists clarify how tumour cells kill specific cells in vascular wall to establish metastases

Scientists clarify how tumour cells kill specific cells in vascular wall to establish metastases

Many cancers only become a mortal danger if they form metastases elsewhere in the body. Such secondary tumours are formed when individual cells break away from the main tumour and travel through the bloodstream to distant areas of the body. [More]
Watch-and-wait approach may prove successful in subset of adults with advanced kidney cancer

Watch-and-wait approach may prove successful in subset of adults with advanced kidney cancer

Watch-and-wait approach means some patients could delay taking highly toxic non-curative anticancer drugs that come with substantial side effects [More]
Research could help develop better therapies for new subtype of adenocarcinoma  patients

Research could help develop better therapies for new subtype of adenocarcinoma patients

Lung cancer is the most common cause of cancer deaths, accounting for about a third of all tumor-related deaths. Adenocarcinomas, a non-small cell lung cancer (NSCLC), account for about 40 percent of cancer diagnoses, but few treatments are available for the disease. [More]
Rice University bioengineer receives NIH grant to study use of AAV-based therapy to combat ovarian cancer

Rice University bioengineer receives NIH grant to study use of AAV-based therapy to combat ovarian cancer

Rice University bioengineer Junghae Suh has been awarded a prestigious R01 grant by the National Institutes of Health to research the use of viral gene therapy to fight ovarian cancer. [More]
Study shows how cancer cells pursue path toward greater concentrations of oxygen

Study shows how cancer cells pursue path toward greater concentrations of oxygen

Cancer cells need oxygen to survive, as do most other life forms, but scientists had never tracked their search for oxygen in their early growth stages until now -- a step toward a deeper understanding of one way cancer spreads that could help treat the disease. [More]
UCI molecular biologists find new way to combat skin cancer

UCI molecular biologists find new way to combat skin cancer

Using new and innovative immune-therapeutic approaches to silence "don't eat me" signaling proteins recognized by specialized cells of the immune system, University of California, Irvine molecular biologists and their colleagues have identified an effective way to combat metastatic melanoma. [More]
T-cell technology could be used to treat ovarian tumors with no adverse effects

T-cell technology could be used to treat ovarian tumors with no adverse effects

With only incremental improvements in ovarian cancer survival over the last 40 years, there is a clear need for new treatment options with long-lasting results. Many researchers have turned toward the development of immunotherapies that direct T-cells to selectively eliminate ovarian tumor cells, but an appropriate therapeutic target for ovarian cancers has remained elusive. [More]
ZMYND8 protein can suppress metastasis-linked genes in prostate cancer

ZMYND8 protein can suppress metastasis-linked genes in prostate cancer

Although it reads like European license plate number, a protein known as ZMYND8 has demonstrated its ability to block metastasis-linked genes in prostate cancer, according to a study at The University of Texas MD Anderson Cancer Center. [More]
New study uncovers way to characterize black box of malignant melanoma

New study uncovers way to characterize black box of malignant melanoma

When malignant melanoma metastasizes to the brain, it is a death sentence for most patients. Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery. [More]
Adhesive patch can deliver triple combination therapy to tumor sites

Adhesive patch can deliver triple combination therapy to tumor sites

Approximately one in 20 people will develop colorectal cancer in their lifetime, making it the third-most prevalent form of the disease in the U.S. In Europe, it is the second-most common form of cancer. [More]
ASTRO clinical practice statement outlines recommendations to customize treatment for rectal cancer

ASTRO clinical practice statement outlines recommendations to customize treatment for rectal cancer

The American Society for Radiation Oncology recently issued a new clinical practice statement, "Appropriate Customization of Radiation Therapy for Stage II and III Rectal Cancer: An ASTRO Clinical Practice Statement Using the RAND/UCLA Appropriateness Method." [More]
New subcutaneous treatment reduces pain, increases survival chances of breast cancer patients

New subcutaneous treatment reduces pain, increases survival chances of breast cancer patients

Breast cancer treatments are usually painful, time consuming and aggressive, which leads to long term hospitalization, medical staff and high economic expenses. [More]
New mathematical model can help predict breast cancer growth, occurrence of metastases

New mathematical model can help predict breast cancer growth, occurrence of metastases

Personalized medicine is a healthcare approach in which medical procedures are tailored to the individual patient's genetic, physiological, and biochemical type along with other characteristics. Cancer treatment is one type of care where a personalized approach is most needed and often applied. [More]
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