Methotrexate News and Research

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Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.

Methotrexate is approved by the Food and Drug Administration (FDA) to be used by itself to treat the following types of gestational trophoblastic tumors, Chorioadenoma destruens, Choriocarcinoma, Hydatidiform mole. Methotrexate is also approved to be used alone or with other drugs to treat acute lymphoblastic leukemia (ALL) that has spread to the central nervous system (CNS) or to keep it from spreading there, and to treat the following, breast cancer, certain types of head and neck cancer, lung cancer, advanced non-Hodgkin lymphoma (NHL), advanced mycosis fungoides (a type of cutaneous T-cell lymphoma), osteosarcoma that has not spread to other parts of the body, following surgery to remove the primary tumor. Methotrexate is also approved to treat the following non-cancer conditions, rheumatoid arthritis, severe psoriasis.
New BSR guideline provides evidence-based recommendations for clinicians prescribing non-biologic DMARDs

New BSR guideline provides evidence-based recommendations for clinicians prescribing non-biologic DMARDs

Researchers develop new assay for measuring underlying autoimmunity in rheumatoid arthritis patients

Researchers develop new assay for measuring underlying autoimmunity in rheumatoid arthritis patients

UTHealth and Children's Memorial Hermann begin two new clinical trials for pediatric brain cancer

UTHealth and Children's Memorial Hermann begin two new clinical trials for pediatric brain cancer

Phenotypic Personalized Medicine could surmount treatment challenges for acute lymphoblastic leukemia

Phenotypic Personalized Medicine could surmount treatment challenges for acute lymphoblastic leukemia

Research unlocks potential new therapies for inflammatory diseases

Research unlocks potential new therapies for inflammatory diseases

Over-the-counter and prescription pain medications linked to drug-induced liver injury

Over-the-counter and prescription pain medications linked to drug-induced liver injury

Smoking, excess weight may influence how rheumatoid arthritis symptoms improve with treatment

Smoking, excess weight may influence how rheumatoid arthritis symptoms improve with treatment

CreakyJoints announces first patient-friendly guidelines for rheumatoid arthritis

CreakyJoints announces first patient-friendly guidelines for rheumatoid arthritis

FDA approves expanded use of systemic therapy for treating chronic moderate-to-severe pediatric psoriasis

FDA approves expanded use of systemic therapy for treating chronic moderate-to-severe pediatric psoriasis

Scientists discover genomic alterations in pediatric relapsed ALL

Scientists discover genomic alterations in pediatric relapsed ALL

Can-Fite BioPharma reports financial results, provides update on drug development programs

Can-Fite BioPharma reports financial results, provides update on drug development programs

Penn State dermatologist clarifies common myths about psoriasis

Penn State dermatologist clarifies common myths about psoriasis

Psoriasis treatments may help improve cardiovascular symptoms by reducing skin inflammation

Psoriasis treatments may help improve cardiovascular symptoms by reducing skin inflammation

Immunotherapy-treated cancer patients may develop rheumatic disorders

Immunotherapy-treated cancer patients may develop rheumatic disorders

Factors other than just cost may influence prescribing of TNF inhibitors for RA patients

Factors other than just cost may influence prescribing of TNF inhibitors for RA patients

Study sheds light on why many RA patients do not adhere to treatment

Study sheds light on why many RA patients do not adhere to treatment

Smoking, obesity lower chances of achieving sustained remission in early RA patients

Smoking, obesity lower chances of achieving sustained remission in early RA patients

BNPs have potential to enable early diagnosis, long-term treatment of RA with minimal side effects

BNPs have potential to enable early diagnosis, long-term treatment of RA with minimal side effects

Study finds differences in hospitalization trends for gout and rheumatoid arthritis

Study finds differences in hospitalization trends for gout and rheumatoid arthritis

Pembrolizumab drug shows significant clinical responses in metastatic head and neck cancer patients

Pembrolizumab drug shows significant clinical responses in metastatic head and neck cancer patients