MicroRNA News and Research

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In genetics, microRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein (i.e. they are non-coding RNAs); instead each primary transcript (a pri-miRNA) is processed into a short stem-loop structure called a pre-miRNA and finally into a functional miRNA. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression.

Understanding regulatory effects of miRNAs on myocardial cell injury after coronary microembolization

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Coronary microembolization (CME) occurs in patients with acute coronary syndrome and is caused primarily by atherosclerotic plaque rupture associated with surgery.

15 Apr 2024

Restoring insulin sensitivity without TZD side effects

Thiazolidinediones (TZDs) are a class of drug that can be used to treat type 2 diabetes by reversing insulin resistance, one of the main hallmarks of the disease.

13 Apr 2024

miR-205 knockout surprises with enhanced mammary development and cancer insights

New research unveils the paradoxical role of miR-205 in mammary gland development and its potential impact on breast cancer, highlighting the miRNA's complex involvement in stem cell regulation and tumor suppression.

2 Apr 2024

Researchers pioneer a novel approach to enhance diabetic wound healing

Researchers unveiled a novel therapy for diabetic wound healing. This research highlights the use of exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells (BMSCs) to significantly enhance wound healing by promoting keratinocyte autophagy.

14 Mar 2024

Innovative diagnostic platform uses sound waves for exosome-based disease detection

Mechanical engineers at Duke University have devised a new type of diagnostic platform that uses sound waves to spin an individual drop of water up to 6,000 revolutions per minute.

13 Mar 2024

Novel therapy harnesses stem cell-derived exosomes for diabetic wound healing

20 Feb 2024

Mediterranean diet linked to better semen quality, study finds

A systematic review reveals that adherence to the Mediterranean diet improves semen quality in men of reproductive age, suggesting a positive impact on male reproductive health.

19 Feb 2024

New cervical cancer detection method promises to reduce unnecessary screenings

The BMC Medicine study introduces the CerMe detection method, using PCDHGB7 hypermethylation to effectively triage high-risk HPV-positive women, potentially reducing unnecessary colposcopy referrals.

8 Feb 2024

Study shows how low dose of cadmium produces deleterious stress in lung epithelial cells

Cigarette smoke exposure is associated with the development and severity of chronic obstructive pulmonary disease, or COPD, which is the third leading cause of death worldwide.

2 Feb 2024

New study identifies key role of microRNA-29 in scar-free wound healing

New findings in The American Journal of Pathology, published by Elsevier, report that a class of small RNAs (microRNAs), microRNA-29, can restore normal skin structure rather than producing a wound closure by a connective tissue (scar).

2 Feb 2024

New brush test outperforms biopsies in early oral cancer detection

A new test invented by University of Illinois Chicago researchers allows dentists to screen for the most common form of oral cancer with a simple and familiar tool: the brush.

17 Jan 2024

3D nanomatrix vascular sheet model for high-throughput atherosclerosis drug testing

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

12 Jan 2024

Paternal sperm microRNAs also play a role in offspring health

A recent study has reported that changes in mice sperm microRNAs brought about by aging may affect the growth and development of offspring.

12 Jan 2024

Intestine epithelium-derived exosomes serve as novel mediator in regulating hepatic lipid metabolism

Non-alcoholic fatty liver disease (NAFLD), characterized by excessive hepatic lipid accumulation, poses a high prevalence and can progress to cirrhosis and liver cancer.

11 Dec 2023

Scientists unmask molecule that fuels leukemia growth

In a study published in the journal Genes & Diseases, researchers from Beckman Research Institute of City of Hope, explored the impact of m6A modification on the maturation process of precursor microRNAs (pre-miRNAs) and its potential role in tumorigenesis.

4 Dec 2023

Study shows how aging affects communication between skin cells

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 22, entitled, "Chronological aging impacts abundance, function and microRNA content of extracellular vesicles produced by human epidermal keratinocytes."

30 Nov 2023

MicroRNA News and Research

Further Reading

Understanding regulatory effects of miRNAs on myocardial cell injury after coronary microembolization

Restoring insulin sensitivity without TZD side effects

miR-205 knockout surprises with enhanced mammary development and cancer insights

Researchers pioneer a novel approach to enhance diabetic wound healing

Innovative diagnostic platform uses sound waves for exosome-based disease detection

Novel therapy harnesses stem cell-derived exosomes for diabetic wound healing

Mediterranean diet linked to better semen quality, study finds

New cervical cancer detection method promises to reduce unnecessary screenings

Study shows how low dose of cadmium produces deleterious stress in lung epithelial cells

New study identifies key role of microRNA-29 in scar-free wound healing

New brush test outperforms biopsies in early oral cancer detection

3D nanomatrix vascular sheet model for high-throughput atherosclerosis drug testing

Paternal sperm microRNAs also play a role in offspring health

Intestine epithelium-derived exosomes serve as novel mediator in regulating hepatic lipid metabolism

Scientists unmask molecule that fuels leukemia growth

Study shows how aging affects communication between skin cells

Silencing galectin 1 protein shrinks liver cancer tumors in mice

Novel miRNA-based therapy shows promise for treatment of drug-resistant biliary tract cancer

Study uses cellulose sheets to map body's extracellular vesicles, unlocking disease insights

Researchers identify specific genes, brain regions, and cognitive features associated with depression

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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