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Penn researchers discover antimicrobial that thwarts Zika viral entry into human cells

Penn researchers discover antimicrobial that thwarts Zika viral entry into human cells

A panel of small molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor of Zika viral entry into relevant human cell types, was discovered by researchers from the Perelman School of Medicine at the University of Pennsylvania. [More]
Epigenetic changes drive successful metastases of pancreatic cancer cells

Epigenetic changes drive successful metastases of pancreatic cancer cells

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells. [More]
Researchers find explanation for link between persistent infection and long-term immunity

Researchers find explanation for link between persistent infection and long-term immunity

Many infectious diseases are one and done; people get sick once and then they are protected from another bout of the same illness. [More]
Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Metastatic pancreatic cancer -- cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths -- changes its metabolism and is "reprogrammed" for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics. [More]
Scientists identify Smurf1 protein that plays role in autophagy of TB bacteria

Scientists identify Smurf1 protein that plays role in autophagy of TB bacteria

UT Southwestern Medical Center researchers have identified a protein that is central to the immune system's ability to recognize and destroy the bacterium responsible for the global tuberculosis (TB) epidemic. [More]
Penn Vet researchers identify potential target to fight against Ebola

Penn Vet researchers identify potential target to fight against Ebola

Viruses and their hosts are in a eternal game of one-upmanship. If a host cell evolves a way to stop a virus from spreading, the virus will look for a new path. And so on and so forth. [More]
S. pneumoniae uses hosts' immune defenses to spread infection, study reveals

S. pneumoniae uses hosts' immune defenses to spread infection, study reveals

The bacteria that cause most cases of pneumonia worldwide secrete a toxin that helps them jump from one body to the next - with help from the hosts' immune defenses. This is the finding of a study led by researchers from NYU Langone Medical Center and published online January 11 in Cell Host & Microbe. [More]
MUSC scientists design novel antibody-based therapy to fight against cancer

MUSC scientists design novel antibody-based therapy to fight against cancer

Scientists at the Medical University of South Carolina (MUSC) have designed an antibody-based therapy that could target the functions of TGF-beta that cause cancer [More]
Study shows how phage-resistant cells become susceptible upon co-incubation with sensitive bacteria

Study shows how phage-resistant cells become susceptible upon co-incubation with sensitive bacteria

Bacteriophages (phages) are probably the most abundant entities in nature, often exceeding bacterial densities by an order of magnitude. [More]
UJI researchers develop new light-activated antimicrobial material to combat hospital infections

UJI researchers develop new light-activated antimicrobial material to combat hospital infections

Researchers at the Universitat Jaume I in Castellón, Spain, have developed a new light-activated antimicrobial material for use in the fight against the most common hospital infections. [More]
Researchers identify sub-population of HIV-1 strains with biological properties to transmit new infections

Researchers identify sub-population of HIV-1 strains with biological properties to transmit new infections

Upon sexual exposure, the AIDS virus must overcome some mighty barriers to find the right target cell and establish a new infection. [More]
New research paves way for better strategies to diagnose and manage vascular graft infections

New research paves way for better strategies to diagnose and manage vascular graft infections

A rising prevalence of cardiovascular disease has generated substantial growth in the use of medical implants, such as vascular grafts. [More]
Archaeologist discovers 800-year-old genomes from bacterial infection in Byzantine skeleton

Archaeologist discovers 800-year-old genomes from bacterial infection in Byzantine skeleton

Eight hundred years ago, in a hardscrabble farming community on the outskirts of what was once one of the fabled cities of the ancient world, Troy, a 30-year-old woman was laid to rest in a stone-lined grave. [More]
Penn State researchers develop novel compound to combat cytomegalovirus

Penn State researchers develop novel compound to combat cytomegalovirus

A Retro94-based compound may prevent a common and sometimes fatal virus -- human cytomegalovirus (CMV) -- from reproducing and help to protect immunocompromised patients, such as those with HIV, on chemotherapy, with transplants, and infants from the effects of the disease, according to Penn State College of Medicine researchers. [More]
Dutch scientists discover favorable conditions for growth of Legionella bacteria

Dutch scientists discover favorable conditions for growth of Legionella bacteria

The bacteria that cause Legionnaire's disease grow well in warm tap water installations with ample dissolved organic matter--conditions that support the growth of biofilms. The research is published January 6th in Applied and Environmental Microbiology, a journal of the American Society for Microbiology. [More]
Anemia protects children against blood-stage malaria in Africa, UNC study finds

Anemia protects children against blood-stage malaria in Africa, UNC study finds

Iron deficiency is the most common nutritional deficiency in the world and causes long-term adverse consequences in children. [More]
ESCMID grant helps young investigators to study microorganisms, find better approaches to treat infectious diseases

ESCMID grant helps young investigators to study microorganisms, find better approaches to treat infectious diseases

The European Society of Clinical Microbiology and Infectious Diseases through its annual grant programme helps young investigators pursue ground-breaking research to advance our understanding of microorganisms and find better approaches to diagnose, prevent and treat infectious diseases. [More]
How does the brain control appetite?

How does the brain control appetite?

Energy balance between energy intake and expenditure in our bodies is important for maintaining energy homeostasis to keep our bodies functioning properly. The appetite determines how much we eat, the energy intake, by communication between the brain and body. [More]
Specific gene pathway appears to regulate growth, structure, and organization of cerebral cortex

Specific gene pathway appears to regulate growth, structure, and organization of cerebral cortex

One of the most significant ways in which the human brain is unique is the size and structure of the cerebral cortex. But what drives the growth of the human cortex, likely the foundation for our unique intellectual abilities? [More]
Genomic sequencing reveals new insights into major shigellosis outbreaks in California

Genomic sequencing reveals new insights into major shigellosis outbreaks in California

In a study that could have significant impact on how disease outbreaks are managed, researchers at UC Davis and the California Department of Public Health have sequenced and analyzed genomes from Shigella sonnei (S. sonnei) bacteria associated with major shigellosis outbreaks in California in 2014 and 2015. [More]
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