Mitochondria News and Research

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Study reveals relationship between circadian rhythm and mitochondrial network

Cellular energy metabolism also follows the rhythm of the circadian clock. A University of Basel study has now shown exactly how this works by revealing the relationship between the circadian rhythm and the mitochondrial network for the first time.

6 Mar 2018

TSRI research offers explanation for why neurons die off in Parkinson's disease

An estimated 10 million people worldwide are living with Parkinson's disease--an incurable neurodegenerative disorder that leads to an increasing loss of motor control.

6 Mar 2018

University of Guelph researcher discovers cause of nerve cell death in Parkinson's disease

A University of Guelph researcher has discovered one of the factors behind nerve cell death in Parkinson's disease, unlocking the potential for treatment to slow the progression of this fatal neurodegenerative disorder.

27 Feb 2018

Research reveals how mutant p53 enhances tumor metastasis

Scientists at The Wistar Institute have found a novel mechanism through which mutant p53 enhances metastasis by controlling tumor metabolism. The research, published online in Genes & Development, also revealed how this process is influenced by a naturally occurring p53 gene variant.

26 Feb 2018

Researchers discover new weakness in sleeping sickness parasites

Trypanosomes are single-celled parasites that cause diseases such as human African sleeping sickness and Nagana in animals. But they are also used in basic research as a model system to study fundamental biological questions.

21 Feb 2018

Researchers discover that activation of specific enzyme may help suppress tumor metastasis

To stop the spread of cancer, cancer cells must die. Unfortunately, many types of cancer cells seem to use innate mechanisms that block cancer cell death, therefore allowing the cancer to metastasize.

19 Feb 2018

DNA plays unexpected architectural role in shaping cells, study finds

As a basic unit of life, the cell is one of the most carefully studied components of all living organisms. Yet details on basic processes such as how cells are shaped have remained a mystery.

8 Feb 2018

Scientists develop new technique to 'turn off' multi-drug resistance capabilities in cancer cells

The ability for cancer cells to develop resistance to chemotherapy drugs - known as multi-drug resistance - remains a leading cause for tumor recurrence and cancer metastasis, but recent findings offer hope that oncologists could one day direct cancer cells to "turn off" their resistance capabilities.

8 Feb 2018

HDAC6 inhibition could be promising therapeutic approach for peripheral neuropathies

Inhibiting HDAC6 improves the structural stability of cells and protects against neuronal damage. Leuven research uncovered that targeting this mechanism could be a promising therapeutic approach for peripheral neuropathies, whether due to Charcot-Marie-Tooth disease (CMT) or as a side effect of chemotherapy.

8 Feb 2018

Loss of coenzyme Q10 increases pre-diabetes risk

Levels of CoQ and the presence of insulin resistance were analyzed in a range of experimental laboratory settings, mouse models and samples from humans, as part of an ambitious research collaboration conducted with the University of Sydney, Victor Chang Cardiac Research Institute, Duke University School of Medicine, Garvan Institute of Medical Research, Genentech Inc. and the University of New South Wales.

7 Feb 2018

Mitochondrial DNA may play more important role in metastatic cancer than previously thought

DNA found in the mitochondria may play a more significant role in metastatic cancer than originally thought.

6 Feb 2018

Ribosomes found to be cause of somatic cell pluripotency

In 2012, a Japanese research group discovered that human skin cells acquire pluripotency when introduced to lactic acid bacteria. Now, the same group of researchers have found that the cause of somatic cell conversion into pluripotent stem cells is the ribosome, a protein synthesizing cellular organelle.

5 Feb 2018

Doctors receive permission to carry out first “three-person baby” procedure in UK

Doctors have been given permission to assist two women in becoming pregnant with “three-person” babies for the first time in the UK.

5 Feb 2018

Study uncovers potential targets for treatment of aggressive triple-negative breast cancers

As part of a breast-cancer diagnosis, doctors analyze the tumor to determine which therapies might best attack the malignancy.

2 Feb 2018

Specialized cellular structures may hold clues to health effects of psychological stress

How does psychological stress translate into physical health effects? A key piece of the puzzle may be found in specialized cellular structures known as mitochondria, according to a pair of articles in the January issue of Psychosomatic Medicine: Journal of Biobehavioral Medicine, the official journal of the American Psychosomatic Society.

2 Feb 2018

Vitamin deficiency prevents proliferation of cancer stem cells

DPI effectively switches off the cancer stem cells, preventing their proliferation. "It's extraordinary; the cells just sit there as if in a state of suspended animation" explains Professor Michael Lisanti, Chair of Translational Medicine and lead investigator.

30 Jan 2018

Viral replication process weak spot may help develop cure for infections

Researchers at the Morgridge Institute for Research believe they have identified a weak spot in the replication process of positive-strand RNA viruses, which could yield treatment for viral infections such as Zika, Polio, Chikungunya, Hepatitis C and even common cold viruses.

29 Jan 2018

Scientists discover direct physical contact between two key cellular structures

Northwestern Medicine scientists have discovered that two key cellular structures, called mitochondria and lysosomes, come into direct contact with each other in the cell to regulate their respective functions.

27 Jan 2018

EXD2 enzyme facilitates protein production in mitochondria

Researchers from the Genomic Instability and Cancer Laboratory at Institute for Research in Biomedicine (IRB Barcelona) have identified a key role for EXD2 in protein production in the mitochondria, the cellular organelles responsible for the majority of energy generation.

17 Jan 2018

Bile acids: A new therapy against obesity

Obesity arises from an imbalance between energy intake and energy expenditure. As a result, current treatments try to decrease calorie intake and/or increase energy expenditure.

17 Jan 2018

Mitochondria News and Research

Study reveals relationship between circadian rhythm and mitochondrial network

TSRI research offers explanation for why neurons die off in Parkinson's disease

University of Guelph researcher discovers cause of nerve cell death in Parkinson's disease

Research reveals how mutant p53 enhances tumor metastasis

Researchers discover new weakness in sleeping sickness parasites

Researchers discover that activation of specific enzyme may help suppress tumor metastasis

DNA plays unexpected architectural role in shaping cells, study finds

Scientists develop new technique to 'turn off' multi-drug resistance capabilities in cancer cells

HDAC6 inhibition could be promising therapeutic approach for peripheral neuropathies

Loss of coenzyme Q10 increases pre-diabetes risk

Mitochondrial DNA may play more important role in metastatic cancer than previously thought

Ribosomes found to be cause of somatic cell pluripotency

Doctors receive permission to carry out first “three-person baby” procedure in UK

Study uncovers potential targets for treatment of aggressive triple-negative breast cancers

Specialized cellular structures may hold clues to health effects of psychological stress

Vitamin deficiency prevents proliferation of cancer stem cells

Viral replication process weak spot may help develop cure for infections

Scientists discover direct physical contact between two key cellular structures

EXD2 enzyme facilitates protein production in mitochondria

Bile acids: A new therapy against obesity

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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