Mitochondria News and Research

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UT Southwestern researchers identify protein that can kick-start more efficient, healthful breakdown of fat

Researchers at UT Southwestern Medical Center have found that a protein often located on the surface of fat droplets within cells - and especially abundant in the muscles of endurance athletes - can kick-start the more efficient and healthful breakdown of fat.

27 Aug 2016

TSRI study sheds light on how mitochondrial calcium can affect learning and memory

While calcium's importance for our bones and teeth is well known, its role in neurons—in particular, its effects on processes such as learning and memory—has been less well defined.

26 Aug 2016

UCSF researchers identify new strategy to cultivate beneficial energy-burning fat

UC San Francisco researchers studying beige fat — a calorie-burning tissue that can help to ward off obesity and diabetes — have discovered a new strategy to cultivate this beneficial blubber.

25 Aug 2016

Surgical repair of mitral valve may provide greater benefit in patients with no symptoms

A new study recently published in the Journal of Thoracic and Cardiovascular Surgery questions whether patients with isolated moderate to severe mitral valve regurgitation should receive treatment in earlier stages instead of waiting until symptoms appear.

25 Aug 2016

UT Southwestern researchers discover protein that can promote healthful breakdown of fat

25 Aug 2016

Novel innovation could help scientists study new treatments for mitochondrial diseases

A new study published in the Proceedings of the National Academy of Sciences from the University of Missouri has succeeded in creating embryos with "heteroplasmy," or the presence of both maternal and paternal mitochondrial DNA.

23 Aug 2016

Umbilical cells from babies of obese mothers show impaired expression of vital genes regulating metabolism

Scientists have long known that infants born to women who are obese show higher risks of obesity, but they don't fully understand what boosts those risks.

23 Aug 2016

Injecting omega-3 fatty acid reduces brain damage in neonatal mouse model of stroke

Researchers from Columbia University Medical Center found that omega-3 fatty acids reduced brain damage in a neonatal mouse model of stroke.

23 Aug 2016

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Before I explain the discovery, I would take a step back and explain an interesting event that takes place in the cancer cells. Normal cells follow a rapid and irreversible process to efficiently eradicate dysfunctional cells. This is a natural process by which damaged cells commit ‘suicide’. This process is known as apoptosis or programmed cell death.

15 Aug 2016

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic biguanide, also inhibits respiration, but proguanil, which is widely used for the prevention of malaria, does not.

12 Aug 2016

Pancreatic cancer cells find alternative source of nutrition to avoid starvation

Pancreatic cancer cells avert starvation in dense tumors by ordering nearby support cells to supply them with an alternative source of nutrition.

11 Aug 2016

Cutting off fuel to cancer cells may be potential therapeutic strategy for Kras-driven lung cancers

Research from investigators at Rutgers Cancer Institute of New Jersey and Princeton University has identified a new approach to cancer therapy in cutting off a cancer cell's 'fuel supply' by targeting a cellular survival mechanism known as autophagy.

11 Aug 2016

Penn study sheds light on role of essential compound in maintaining optimal muscle function

Maintaining proper levels of an essential helper molecule is crucial for optimal muscle function, according to a study led by Joseph Baur, PhD, an assistant professor of Physiology in the Perelman School of Medicine at the University of Pennsylvania.

10 Aug 2016

Wistar scientists discover novel mechanism that helps tumors adapt to hypoxia

One of the many reasons tumors are so difficult to treat is that they are able to adapt whenever they are exposed to unfavorable conditions.

9 Aug 2016

Research findings may have implications for ALS and other neurological disorders

Amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease) is a progressive disorder that devastates motor nerve cells. People diagnosed with ALS slowly lose the ability to control muscle movement, and are ultimately unable to speak, eat, move, or breathe.

4 Aug 2016

Metabolic-checkpoint inhibitor combination approach may improve cancer therapies

Reprogramming of the molecular pathways underlying normal metabolism is essential for T cell infection-fighting function and for the immune system to form a "memory" of the microbes it has already encountered. But exactly how metabolism in exhausted T cells is maintained in chronic infections and cancer is a missing element in this line of research.

3 Aug 2016

Biologists discover male-harming mtDNA mutant that substantiates mother's curse hypothesis

There is new evidence that the "mother's curse" - the possibility that moms may transmit genes to their children that harm their sons but not their daughters - holds true in animals.

3 Aug 2016

Research finding opens door to potential clinical approaches that may boost body's ability to battle cancer

The microenvironment that supports a cancerous tumor also starves the immune cells that the body sends in to destroy the cancer, University of Pittsburgh Cancer Institute scientists revealed in a discovery that holds the potential to significantly boost the performance of breakthrough immunotherapy drugs.

2 Aug 2016

Researchers find promising new therapy for both pediatric and adult cancers

A study conducted at Nationwide Children's Hospital has found that a new chemotherapy is effective against both pediatric and adult cancers, and that it allows other chemotherapies to more readily reach their targets.

28 Jul 2016

Large study of familial ALS finds new gene variant present in 3% of all patients with disease

Variations in a gene with multiple functions in neurons are present in approximately 3 percent of all cases of ALS in North American and European populations, both sporadic and familial, making it one of the most common genetic causes of the disease, according to a paper published in Nature Genetics.

26 Jul 2016

Mitochondria News and Research

UT Southwestern researchers identify protein that can kick-start more efficient, healthful breakdown of fat

TSRI study sheds light on how mitochondrial calcium can affect learning and memory

UCSF researchers identify new strategy to cultivate beneficial energy-burning fat

Surgical repair of mitral valve may provide greater benefit in patients with no symptoms

UT Southwestern researchers discover protein that can promote healthful breakdown of fat

Novel innovation could help scientists study new treatments for mitochondrial diseases

Umbilical cells from babies of obese mothers show impaired expression of vital genes regulating metabolism

Injecting omega-3 fatty acid reduces brain damage in neonatal mouse model of stroke

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

Pancreatic cancer cells find alternative source of nutrition to avoid starvation

Cutting off fuel to cancer cells may be potential therapeutic strategy for Kras-driven lung cancers

Penn study sheds light on role of essential compound in maintaining optimal muscle function

Wistar scientists discover novel mechanism that helps tumors adapt to hypoxia

Research findings may have implications for ALS and other neurological disorders

Metabolic-checkpoint inhibitor combination approach may improve cancer therapies

Biologists discover male-harming mtDNA mutant that substantiates mother's curse hypothesis

Research finding opens door to potential clinical approaches that may boost body's ability to battle cancer

Researchers find promising new therapy for both pediatric and adult cancers

Large study of familial ALS finds new gene variant present in 3% of all patients with disease

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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