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Scientists identify signaling pathway in liver cells linked to fibrosis

A healthy liver filters all the blood in your body, breaks down toxins and digests fats. It produces collagen to repair damaged cells when the liver is injured.

25 Apr 2024

Synthetic nanomaterial could be an effective tool for treating neurodegenerative diseases

A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases.

25 Apr 2024

Study identifies molecular pathway in liver cancer development

As a malignant disease of the liver cells, hepatocellular carcinoma (HCC) is one of the main causes of cancer-related deaths.

23 Apr 2024

Immune dysfunction mechanism discovered in stroke and heart attack patients

Every year, between 250,000 and 300,000 people in Germany suffer from a stroke or heart attack.

23 Apr 2024

Innovative malaria prodrug targets liver, enhances efficacy while reducing toxicity, preclinical studies show

Tafenoquine, a prodrug that could fulfill the criteria for a mass eradication campaign.

23 Apr 2024

Breakthrough study reveals role of histone deacetylases in inflammatory bowel disease

In a scientific breakthrough, Mount Sinai researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.

22 Apr 2024

Study explores the effects of ovulation inducing method on embryo quality

Low birth rates have become a serious problem in many developed countries throughout the world, with Japan being a prime example. In Japan particularly, aging and stress have led to a massive rise in infertility, which now affects one in every 4.4 couples.

22 Apr 2024

Liver cells effectively serve as immune checkpoint regulating anti-cancer immunity

Liver inflammation, a common side-effect of cancers elsewhere in the body, has long been associated with worse cancer outcomes and more recently associated with poor response to immunotherapy.

22 Apr 2024

Study explores tocotrienols' neuroprotective effects in obesity-related cognitive decline

Obesity has become a pressing worldwide health issue, with rates steadily rising over recent decades.

18 Apr 2024

Study identifies genomic variant linked to unique human skull base morphology

Humans, Homo sapiens, have unique features compared with other closely related hominin species and primates, including the shape of the base of the skull.

17 Apr 2024

Exploring how gene variants affect brain cells in children with severe epilepsy

Epilepsy is a brain disorder that causes recurring seizures.

16 Apr 2024

U-M study reveals potential pathway to reverse lung fibrosis

The most common type of lung fibrosis -; scarring of the lungs -- is idiopathic, meaning of unknown cause.

13 Apr 2024

Link between aldehydes and premature aging revealed

A team of researchers at Nagoya University in Japan has discovered that aldehydes are metabolic byproducts associated with premature aging.

12 Apr 2024

Researchers create novel drug that can prevent flu-induced lung injury

Infection with the influenza virus leads to lung injury through inflammation over-activation that causes collateral damage to cells required for breathing.

10 Apr 2024

CNIC researchers unravel complexities of Andersen-Tawil syndrome

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has made a breakthrough discovery in the understanding of cardiac arrhythmias by unraveling the complexities of Andersen-Tawil syndrome (ATS), an extremely rare inherited cardiac disorder.

10 Apr 2024

Novel immune cell therapy may be a promising strategy for combating HBV infection

Chronic infection with the hepatitis B virus (HBV) causes progressive liver problems, and eradication of the virus remains a formidable challenge.

10 Apr 2024

CMS121 holds promise for treating metabolic diseases

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 6, entitled, "CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction."

9 Apr 2024

Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

9 Apr 2024