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Prana's PBT2 receives FDA Orphan Drug designation for treatment of Huntington disease

Prana's PBT2 receives FDA Orphan Drug designation for treatment of Huntington disease

Prana Biotechnology has today announced the US Food and Drug Administration has granted Orphan Drug designation to PBT2 for the treatment of Huntington Disease. [More]
Implantating DBS devices poses no greater risk of complications to older Parkinson's patients

Implantating DBS devices poses no greater risk of complications to older Parkinson's patients

Implantating deep brain stimulation devices poses no greater risk of complications to older patients than it does to younger patients with Parkinson's disease, researchers at Duke Medicine report. [More]
Treatments that involve neck manipulation may be linked with strokes

Treatments that involve neck manipulation may be linked with strokes

Treatments that involve neck manipulation may be associated with strokes, although this association is not proven, according to an American Heart Association Scientific Statement written by lead author Dr. Jose Biller of Loyola University Medical Center and other stroke experts. [More]
Study shows castor bean oil reduces epileptic seizures related to Glut1 deficiency

Study shows castor bean oil reduces epileptic seizures related to Glut1 deficiency

Two years ago, the parents of Chloe Olivarez watched painfully as their daughter experienced epileptic seizures hundreds of times a day. [More]
Nigral neuronal loss and α-synuclein pathology scrutinised in PD

Nigral neuronal loss and α-synuclein pathology scrutinised in PD

The severity of neurodegeneration and local burden of α-synuclein are closely coupled during disease progression in Parkinson’s disease, a post-mortem study has found. [More]
In vivo dopaminergic imaging strongly correlates with brain pathology

In vivo dopaminergic imaging strongly correlates with brain pathology

Striatal dopamine transporter binding, assessed using single-photon emission computed tomography, is strongly correlated with substantia nigra cell counts assessed at postmortem, say the authors of a study. [More]
New study explores processes that establish connections between nerve cells in the brain

New study explores processes that establish connections between nerve cells in the brain

New research provides an intriguing glimpse into the processes that establish connections between nerve cells in the brain. These connections, or synapses, allow nerve cells to transmit and process information involved in thinking and moving the body. [More]
Parkinson's disease drug could also help people with phobias or PTSD

Parkinson's disease drug could also help people with phobias or PTSD

A drug used to treat Parkinson's disease could also help people with phobias or post-traumatic stress disorder (PTSD). Scientists of the Translational Neurosciences Research Center at Johannes Gutenberg University Mainz are currently exploring the effects of psychotherapy to extinguish fears in combination with L-dopa. [More]
Cardiac stress test findings normal in premotor Parkinson’s disease patients

Cardiac stress test findings normal in premotor Parkinson’s disease patients

People who go on to develop Parkinson’s disease do not perform significantly differently from normal controls on exercise stress testing, an Israeli study has found. [More]
Researchers identify genetic mutation that may cause parkinsonism in young people

Researchers identify genetic mutation that may cause parkinsonism in young people

Researchers at the University of Copenhagen and the Copenhagen University Hospital have identified a particular genetic mutation that may cause parkinsonism in young people. The mutation interferes with the brain's transport of the important signal substance dopamine and may also plays a role in mental diseases, e.g. ADHD. [More]
REM sleep disorder: A sign of impending neurodegenerative disease

REM sleep disorder: A sign of impending neurodegenerative disease

How many millions of people suffer from sleep disturbance? One sleep disorder in particular, called REM behavior disorder, could be a sign of impending neurodegenerative disease, including Parkinson's and dementia, say scientists presenting their research at the Society of Nuclear Medicine and Molecular Imaging's 2014 Annual Meeting. [More]
Study heterogeneity hinders mortality predictions in Parkinson’s disease

Study heterogeneity hinders mortality predictions in Parkinson’s disease

Poor study quality and heterogeneity in study methods and patients make it difficult to determine the impact Parkinson’s disease has on mortality, UK researchers report. [More]
Studies show relation between spice and different types of psychosis

Studies show relation between spice and different types of psychosis

Professors of Medicine Degree at the CEU Cardenal Herrera University and the Provincial Hospital of Castellón, in collaboration with doctors of the Addictive Behaviors Unit of Valencia, have described the first case of catatonic psychosis caused by a synthetic derivate of Cannabis: the spice. [More]
Healthy tissue grafted to brains of patients with Huntington's disease also develops signs of illness

Healthy tissue grafted to brains of patients with Huntington's disease also develops signs of illness

A recent study published in Annals of Neurology reports that healthy human tissue grafted to the brains of patients with Huntington's disease in the hopes of treating the neurological disorder also developed signs of the illness, several years after the graft. [More]
Dopamine transporter availability predicts ICDs

Dopamine transporter availability predicts ICDs

Reduced striatal dopamine transporter availability is already present in patients with Parkinson’s disease who go on to develop impulse control disorders, a study shows. [More]
Newron Pharmaceuticals submits safinamide NDA to FDA

Newron Pharmaceuticals submits safinamide NDA to FDA

Newron Pharmaceuticals S.p.A. ("Newron"), a research and development company focused on novel CNS and pain therapies, and its partner Zambon S.p.A., an international pharmaceutical company strongly committed to the CNS therapeutic area with a long experience in respiratory disease therapies, woman care and primary care, announce that the New Drug Application (NDA) for safinamide was submitted today to the US Food and Drug Administration (FDA). [More]
UCLA’s BrainSPORT Program earns $10M to research, treat sport concussions in youth

UCLA’s BrainSPORT Program earns $10M to research, treat sport concussions in youth

Philanthropist Steve Tisch, co-owner of the New York Giants and an Academy Award-winning film producer, has pledged $10 million to the department of neurosurgery at the David Geffen School of Medicine at UCLA for the BrainSPORT Program, which has been renamed the UCLA Steve Tisch BrainSPORT Program. [More]
New research program to understand and treat debilitating psychiatric disorders

New research program to understand and treat debilitating psychiatric disorders

Scientists and physicians at UC San Francisco (UCSF) are leading a $26 million, multi-institutional research program in which they will employ advanced technology to characterize human brain networks and better understand and treat a range of common, debilitating psychiatric disorders, focusing first on anxiety disorders and major depression. [More]
Eye movement disorder increases as we age, study finds

Eye movement disorder increases as we age, study finds

Abnormal binocular vision, which involves the way eyes work together as a team, increases dramatically as we age, according to research from the University of Waterloo. The study also found a correlation between this condition, general health and antidepressant use. [More]
Mayo Clinic neuroscientists define subtype of Alzheimer's disease

Mayo Clinic neuroscientists define subtype of Alzheimer's disease

Neuroscientists at Mayo Clinic in Florida have defined a subtype of Alzheimer's disease (AD) that they say is neither well recognized nor treated appropriately. [More]