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Computer modeling to predict how peripheral nerve axon responds to electrical stimuli

Researchers at Case Western Reserve University have developed a computer modeling method to accurately predict how a peripheral nerve axon responds to electrical stimuli, slashing the complex work from an inhibitory weeks-long process to just a few seconds.

21 Jul 2011

Gene-based test for distinguishing harmless from precancerous pancreatic cysts

Johns Hopkins scientists have developed a gene-based test to distinguish harmless from precancerous pancreatic cysts. The test may eventually help some patients avoid needless surgery to remove the harmless variety.

21 Jul 2011

Promising results from phase I study of Genentech's GDC-0941 for advanced breast cancer

A new drug targeting the PI3K gene in patients with advanced breast cancer shows promising results in an early phase I investigational study conducted at Virginia G. Piper Cancer at Scottsdale Healthcare, according to a presentation by oncologist Dr. Daniel D. Von Hoff at the 47th annual meeting of the American Society of Clinical Oncology.

21 Jul 2011

Male infertility cause found in defective gene

Researchers have found a new cause of infertility that could allow millions of infertile couples around the world to have a child. The team found a common gene mutation that causes sperm to be far less able to swim through the mucus of the cervix and reach the egg.

20 Jul 2011

Latest advances in Alzheimer's research presented at AAIC 2011

This week, more than 5,000 scientists from around the world gathered in Paris to report the latest advances in Alzheimer's research at the Alzheimer's Association International Conference 2011.

20 Jul 2011

Inherited forms of Alzheimer's can be detected years before dementia develops

Inherited forms of Alzheimer's disease may be detectable as many as 20 years before problems with memory and thinking develop, scientists will report July 20, 2011, at the Alzheimer's Association International Conference on Alzheimer's Disease in Paris.

20 Jul 2011

Scientists discover new dominant gene linked to Parkinson's

The newly discovered gene is known as VPS35, the sixth one which has been associated with Parkinson's disease and the third dominant gene.

20 Jul 2011

Nuclear Factor I/B appears to drive progression of small cell lung cancer

A major challenge for cancer biologists is figuring out which among the hundreds of genetic mutations found in a cancer cell are most important for driving the cancer's spread.

20 Jul 2011

Altogen Labs introduces pyrosequencing services for hospitals, research institutions

Altogen Labs, a biology contract research organization and provider of pre-clinical research services, announced its launch of a pyrosequencing service today.

20 Jul 2011

Two key genes may help prevent childhood leukemia

Researchers at The University of Western Ontario have identified genes that may be important for preventing childhood leukemia. Acute lymphoblastic leukemia (ALL) is a cancer of the blood that occurs primarily in young children.

19 Jul 2011

Scientists identify new inherited form of Parkinson's disease

Scientists at the Helmholtz Zentrum München and the Technische Universität München working in cooperation with the Medical University of Vienna have identified a mutation associated with a inherited form of late-onset Parkinson's disease.

19 Jul 2011

Neutrons show how massive enzyme complexes inside cells control rate of sugar metabolism

Neutrons have shown how massive enzyme complexes inside cells might determine whether sugar is burnt for energy or stored as fat. These findings will improve understanding of diabetes and a range of metabolic diseases.

18 Jul 2011

Study reveals far more genetic mutations involved in formation of colon cancer

Researchers at UT Southwestern Medical Center say there are at least 70 genetic mutations involved in the formation of colon cancer, far more than scientists previously thought.

18 Jul 2011

Experimental online tool launched to guide HIV treatment decisions without the need for resistance testing

A new free online service with the potential to help HIV treatment in countries with limited healthcare resources was launched today. The system accurately predicts how patients will respond to different combinations of drugs without the need for expensive tests to read the viral genetic code. Data presented today at the 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2011) demonstrated the accuracy of the system for patients in Romania and South Africa whose treatment was failing (abstract MOPE146).

18 Jul 2011

Scientists use two methods to manipulate disease-causing mutations in stem cells

Using two distinct methods, Whitehead Institute researchers have successfully and consistently manipulated targeted genes in both human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.

16 Jul 2011

Research: 17 genetic mutations linked to colon cancer formation

Researchers at UT Southwestern Medical Center say there are at least 70 genetic mutations involved in the formation of colon cancer, far more than scientists previously thought.

16 Jul 2011

Researchers discover new gene mutation associated with Parkinson's

Researchers have discovered a new gene mutation they say causes Parkinson's disease. The mutation was identified in a large Swiss family with Parkinson's disease, using advanced DNA sequencing technology.

16 Jul 2011

Researchers discover new gene linked to intellectual disability

A gene linked to intellectual disability was found in a study involving the Centre for Addiction and Mental Health (CAMH) - a discovery that was greatly accelerated by international collaboration and new genetic sequencing technology, which is now being used at CAMH.

15 Jul 2011

Scientists analyze structural changes in calcium channels caused by Timothy-mutation

The human genome encodes 243 voltage-gated ion channels. Mutations in calcium channels can cause severe inherited diseases such as migraine, night blindness, autism spectrum disorders and Timothy syndrome, which leads to severe cardiovascular disorders.

15 Jul 2011

BioMarin commences BMN 673 Phase 1 trial in hematological malignancies

BioMarin Pharmaceutical Inc. today announced the initiation of a Phase 1 trial for BMN 673, a poly ADP-ribose polymerase (PARP) inhibitor, for the treatment of patients with advanced hematological malignancies.

15 Jul 2011