Necrotizing Enterocolitis News and Research

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Necrotizing enterocolitis (NEC) is a life-threatening condition that manifests as inflammation of the intestines. This devastating disease affects mostly premature babies, who account for up to 8 out of every 10 cases. In NEC, bacteria invade the intestinal wall. The resulting local infection and inflammation lead to the destruction of the intestinal lining, even through its entire thickness.

Association between HMO concentrations and infant weight, body composition

Breastfeeding affects infant growth and, researchers have found, helps prevent obesity, both in childhood and later in life. However, the components of breast milk responsible for these beneficial effects remain mostly a mystery.

18 Feb 2020

Award to help advance development of diagnostic test for necrotizing enterocolitis

The Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health has awarded Chosen Diagnostics Inc, a spin-out company, a $299,641 Phase I Small Business Technology Transfer award.

9 Dec 2019

Study finds reliable biomarker for noninvasive detection of deadly infant disease

A diagnostic study of 136 premature infants found that a protein involved in managing harmful bacteria in the human intestine is a reliable biomarker for the noninvasive detection of necrotizing enterocolitis.

8 Nov 2019

Newborn mouse model yields clues to cause of devastating gut disease in anemic preemies

Physicians have long suspected that red blood cell transfusions given to premature infants with anemia may put them in danger of developing necrotizing enterocolitis, or NEC, a potentially lethal inflammatory disease of the intestines.

From Johns Hopkins Medicine 13 Aug 2019

Growth problems in preterm infants associated with altered gut bacteria

A team of researchers at Ann & Robert H. Lurie Children's Hospital of Chicago found that extremely premature babies fail to grow while others develop normally due to certain metabolic differences triggered by specific gut microbiome alterations.

10 Jul 2019

New initiative to increase mothers' ability to provide milk for very low birth weight infants

Researchers at Boston Medical Center initiated a statewide quality improvement imitative to increase mothers' ability to produce and provide milk for very low birth weight infants at their discharge, as well reduce the racial/ethnic disparities in milk production and provision to these infants.

20 Jun 2019

Breastmilk antibody necessary to prevent necrotizing enterocolitis in preterm infants

A new study from the University of Pittsburgh and UPMC Children's Hospital of Pittsburgh finds that an antibody in breastmilk is necessary to prevent necrotizing enterocolitis (NEC)- an often deadly bacterial disease of the intestine-in preterm infants.

17 Jun 2019

First milk expression within 8 hours related to lactation success for very low-birth-weight infants

A study led by physician researchers at Boston Medical Center has shown that first milk expression within eight hours of giving birth is associated with the highest probability of mothers of very low-birth-weight infants being able to provide milk throughout hospitalization in the neonatal intensive care unit.

10 May 2019

Revolutionary discovery paves new way for treatment of necrotizing enterocolitis

Cutting-edge discovery in the lab of Catherine Hunter, MD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago offers a new direction toward treatment of necrotizing enterocolitis - a devastating intestinal emergency that occurs in up to 10 percent of premature infants

19 Apr 2019

Gut bacteria and pregnancy

Researchers from Bar-Ilan University have found that with pregnancy there is a change in the composition of gut bacteria in women. This could be associated with the changing hormonal status they speculate. The results of their study titled, “Progesterone Increases Bifidobacterium Relative Abundance during Late Pregnancy,” were published in the latest issue of the journal Cell Reports.

17 Apr 2019

CHOP researchers use machine-learning models for early detection of sepsis in NICU infants

Automated programs can identify which sick infants in a neonatal intensive care unit (NICU) have sepsis hours before clinicians recognize the life-threatening condition.

1 Mar 2019

Mother’s milk important to protect infants with congenital heart disease from infection

With a lower risk of serious complications and improved feeding and growth outcomes, human milk is strongly preferred as the best diet for infants with congenital heart disease (CHD), according to a research review in Advances in Neonatal Care, official journal of the National Association of Neonatal Nurses. The journal is published in the Lippincott portfolio by Wolters Kluwer.

31 Jan 2019

Researchers gain new insights into development of necrotizing enterocolitis in preemies

Researchers at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, and colleagues, discovered a promising direction toward understanding the development of necrotizing enterocolitis, a devastating intestinal disease commonly affecting premature infants, in order to treat it.

23 Jan 2019

New study finds change in complex sugars found in breastmilk of women taking probiotic

The complex sugars found in human breastmilk, long believed to be fixed in their composition, may change in women who are taking probiotics, according to new research from the University of Rochester Medical Center.

23 Jan 2019

Johns Hopkins researchers identify molecular causes of necrotizing enterocolitis in preemies

Using a mouse model of necrotizing enterocolitis -- a potentially fatal condition that causes a premature infant's gut to suddenly die -- researchers at Johns Hopkins say they have uncovered the molecular causes of the condition and its associated brain injury.

14 Dec 2018

Standardizing feeding practices improves growth trends for micro-preemies

Standardizing feeding practices, including the timing for fortifying breast milk and formula with essential elements like zinc and protein, improves growth trends for the tiniest preterm infants, according to Children's research presented during the Institute for Healthcare Improvement 2018 Scientific Symposium.

11 Dec 2018

Necrotizing Enterocolitis News and Research

Further Reading

Association between HMO concentrations and infant weight, body composition

Award to help advance development of diagnostic test for necrotizing enterocolitis

Study finds reliable biomarker for noninvasive detection of deadly infant disease

Newborn mouse model yields clues to cause of devastating gut disease in anemic preemies

Growth problems in preterm infants associated with altered gut bacteria

New initiative to increase mothers' ability to provide milk for very low birth weight infants

Breastmilk antibody necessary to prevent necrotizing enterocolitis in preterm infants

First milk expression within 8 hours related to lactation success for very low-birth-weight infants

Revolutionary discovery paves new way for treatment of necrotizing enterocolitis

Gut bacteria and pregnancy

CHOP researchers use machine-learning models for early detection of sepsis in NICU infants

Mother’s milk important to protect infants with congenital heart disease from infection

Researchers gain new insights into development of necrotizing enterocolitis in preemies

New study finds change in complex sugars found in breastmilk of women taking probiotic

Johns Hopkins researchers identify molecular causes of necrotizing enterocolitis in preemies

Standardizing feeding practices improves growth trends for micro-preemies

Transplantation of feces may protect preterm children from deadly bowel disease

Prenatal inflammation may explain why some infants are more prone to neonatal sepsis

Researchers find human milk oligosaccharides in amniotic fluid

Researchers develop biofilm formulations that protect from necrotizing enterocolitis

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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