Nephritis News and Research

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Nephritis is the general term used to describe inflammation of the glomerulus, tubules or interstitial tissue in the kidneys. The condition affects functioning of the kidney and its ability to filter blood and excrete waste products via the urine.

Promise in reversing kidney damage caused by lupus shown by cancer drug

A drug used for cancer therapy has shown promise in reversing kidney damage caused by systemic lupus erythematosus.

8 Apr 2020

Low socioeconomic status associated with certain kidney diseases

A new study found an inverse association between socioeconomic status and certain kidney diseases. The findings appear in an upcoming issue of CJASN.

20 Feb 2020

High bacterial levels in half of lupus skin rashes

A new study published in the Journal of Investigative Dermatology reports that half the skin lesions present in patients with lupus show the presence of viable staph bacteria. This makes them more susceptible to skin infections and also increases the risk that the infection will spread to others.

9 Feb 2020

Kidney damage common in patients receiving immunotherapy for cancer, study finds

A new study indicates that kidney damage is fairly common in patients who take immunotherapy medications for treating cancer. The findings, which appear in an upcoming issue of CJASN, will be important for maintaining the kidney health of patients who are prescribed these drugs.

31 Oct 2019

UAB researchers find key role for IgG autoantibodies in IgA nephropathy

The most common form of the kidney disease called glomerulonephritis is IgA nephropathy.

24 Sep 2019

Gut bacterial changes influence lupus treatment results in pregnancy

The course of pregnancy, like that of true love, doesn’t always run smooth when you have lupus, correctly called systemic lupus erythematosus (SLE). This autoimmune disease is an occasionally violent, occasionally subdued, chronic inflammation that constantly smolders within multiple tissues in the body.

16 Sep 2019

Blood clotting proteins in urine act as potent biomarkers for lupus

The team of researchers at the University of Houston found that blood clotting proteins, both the ones that promote blood clotting (prothrombic) and those that disperse them (thrombolytic) are elevated in the urine of patients with lupus nephritis (LN).

7 Aug 2019

Researchers discover blood clotting proteins in urine as biomarkers of lupus nephritis

University of Houston researcher Chandra Mohan is reporting in Arthritis Research and Therapy that clotting proteins, both those that promote blood clots (pro-thrombotic) and those that work to dissipate them (thrombolytic), are elevated in the urine of patients who suffer from lupus nephritis (LN).

7 Aug 2019

Study shows potential culprit behind Lupus

A team of researchers at the Emory University School of Medicine show that patients with SLE or lupus, have abnormal activation of B cells, which is part of the body’s immune system

8 Jul 2019

Researchers identify new clues on tissue damage in rheumatoid arthritis and lupus

Research supported by the Accelerating Medicines Partnership on Rheumatoid Arthritis and Systemic Lupus Erythematosus provides new insights into tissue damage for these autoimmune conditions.

19 Jun 2019

New study shows how a kidney biopsy can be used to tailor treatment for lupus patients

The kidneys of patients living with systemic lupus erythematosus are often under assault, and not all those living with the disease will respond to standard treatment.

21 May 2019

Adverse childhood experiences may contribute to poor health in adults with lupus

Adults with lupus who report having had adverse childhood experiences, such as abuse, neglect and household challenges, report higher disease activity, depression and poorer overall health compared to those without such experiences, according to a study by researchers at UC San Francisco.

9 May 2019

Researchers developing new tests for early detection, monitoring of lupus nephritis

With $5 million in grants from the National Institutes of Health, two University of Houston biomedical researchers are moving the needle on early detection and monitoring of kidney nephritis, or inflammation, in patients who have Systemic Lupus Erythematosus, known simply as lupus.

2 Apr 2019

Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis

A synthetic peptide appears to directly disrupt the destructive inflammation that occurs in nephritis, enabling the kidneys to better recover and maintain their important functions, investigators report.

25 Mar 2019

Lupus Research Alliance announces research awards to accelerate development of new therapies

Can "borrowed" drugs for treating other diseases protect the skin in patients with lupus? Can researchers coax the body to weed out harmful immune cells that drive tissue destruction in lupus? Those are just two of the innovative approaches for lupus therapies recognized by the Lupus Research Alliance with the latest round of its Target Identification in Lupus grants.

11 Jan 2019

Lupus Research Alliance announces 2018 recipients of the Distinguished Innovator Award

The Lupus Research Alliance is proud to announce the 2018 recipients of the Dr. William E. Paul Distinguished Innovator Award in Lupus and Autoimmunity: Nir Hacohen, PhD and Vijay Kuchroo, DVM, PhD. Dr. Hacohen is seeking better ways to treat lupus kidney disease, the major cause of illness and death among patients with lupus.

21 Dec 2018

Combination of Opdivo and Yervoy shows four-year survival benefits in patients with advanced melanoma

Bristol-Myers Squibb Company today announced four-year data from the Phase 3 CheckMate -067 clinical trial - the longest follow-up to date - which continues to demonstrate durable, long-term survival benefits with the first-line combination of Opdivo (nivolumab) and Yervoy (ipilimumab), versus Yervoy alone, in patients with advanced melanoma.

22 Oct 2018

Merck presents MK-1454 Phase 1 data for treatment of advanced solid tumors or lymphomas

Merck, known as MSD outside the United States and Canada, today announced the first presentation of preliminary data from a Phase 1 clinical trial evaluating MK-1454, an investigational STING (stimulator of interferon genes) agonist, as monotherapy and in combination with KEYTRUDA (pembrolizumab), Merck's anti-PD-1 therapy, in patients with advanced solid tumors or lymphomas.

22 Oct 2018

Merck presents KEYNOTE-057 trial results for patients with high-risk non-muscle invasive bladder cancer

Merck, known as MSD outside the United States and Canada, today announced the first presentation of results from an interim analysis of KEYNOTE-057, a Phase 2 trial evaluating KEYTRUDA, Merck's anti-PD-1 therapy, for previously treated patients with high-risk non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ or CIS plus papillary disease (Cohort A).

22 Oct 2018

Organs actively fighting back against autoimmune diseases, finds study

Organs affected by autoimmune disease could be fighting back by "exhausting" immune cells that cause damage using methods similar to those used by cancer cells to escape detection, according to a study by researchers at the University of Pittsburgh School of Medicine published today in the Journal of Clinical Investigation.

25 Sep 2018

Nephritis News and Research

Further Reading

Promise in reversing kidney damage caused by lupus shown by cancer drug

Low socioeconomic status associated with certain kidney diseases

High bacterial levels in half of lupus skin rashes

Kidney damage common in patients receiving immunotherapy for cancer, study finds

UAB researchers find key role for IgG autoantibodies in IgA nephropathy

Gut bacterial changes influence lupus treatment results in pregnancy

Blood clotting proteins in urine act as potent biomarkers for lupus

Researchers discover blood clotting proteins in urine as biomarkers of lupus nephritis

Study shows potential culprit behind Lupus

Researchers identify new clues on tissue damage in rheumatoid arthritis and lupus

New study shows how a kidney biopsy can be used to tailor treatment for lupus patients

Adverse childhood experiences may contribute to poor health in adults with lupus

Researchers developing new tests for early detection, monitoring of lupus nephritis

Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis

Lupus Research Alliance announces research awards to accelerate development of new therapies

Lupus Research Alliance announces 2018 recipients of the Distinguished Innovator Award

Combination of Opdivo and Yervoy shows four-year survival benefits in patients with advanced melanoma

Merck presents MK-1454 Phase 1 data for treatment of advanced solid tumors or lymphomas

Merck presents KEYNOTE-057 trial results for patients with high-risk non-muscle invasive bladder cancer

Organs actively fighting back against autoimmune diseases, finds study

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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