Nephropathy News and Research

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Nephropathy is a broad medical term used to denote disease or damage of the kidney, which can eventually result in kidney failure. The primary and most obvious functions of the kidney are to excrete any waste products and to regulate the water and acid-base balance of the body – therefore loss of kidney function is a potentially fatal condition.

Hypertension drug combination yields high rate of blood pressure control in hard-to-treat patients

The study, conducted at the University of Maryland School of Medicine and 118 other sites, was focused on bringing down systolic blood pressure, the top number in a blood pressure reading, which is the more difficult number to bring down.

18 May 2005

Distributing medications in specially designed blister packages rather than in bottles may increase the likelihood that medications will be taken properly

The study found that patients taking lisinopril – a medication used to treat chronic high blood pressure – were more likely to have their prescriptions refilled on time if the medication came in a blister package rather than as loose tablets in a bottle. In this case, the blister package clearly started the day on which to take each pill.

16 May 2005

Metabolic syndrome costing four times that for all other patients

It is well known that hypertension, diabetes, and obesity are each taking a toll on Americans' health, but according to a new analysis, metabolic syndrome, a condition characterized by a combination of these and/or other risk factors, is fast becoming one of the nation's costliest health concerns.

9 May 2005

Chronic kidney disease linked to a single gene mutation

New research in the US has found that a mutation in a single gene causes a form of chronic kidney disease.

5 May 2005

Specific variants of genes predict bleeding after heart surgery

Duke University Medical Center researchers have found that the presence of specific variants of genes that control clotting and the contractility, or "tone," of blood vessels can double the ability of physicians to predict those heart surgery patients at greatest risk of bleeding after surgery.

4 May 2005

Diabetes appears to rob women of usual advantage in heart disease risk

For men, a heart attack increases the risk of dying from coronary heart disease more than diabetes does, but for women, diabetes is sometimes the greater threat, according to a new study (PDF) in the May 3, 2005, issue of the Journal of the American College of Cardiology.

4 May 2005

Age-related macular degeneration is triggered, possibly by an infection

Age-related macular degeneration, the leading cause of blindness in the elderly, occurs when a common inherited gene variation is triggered, possibly by an infection, according to a new study led by researchers at Columbia University Medical Center and the University of Iowa, with an international research team.

1 May 2005

New guidelines for managing chronic kidney disease in patients living with HIV infection

The HIV Medicine Association has released guidelines for managing chronic kidney disease in patients living with HIV infection. They are published in the June 1 issue of Clinical Infectious Diseases.

27 Apr 2005

Scientists add an important piece to the intricate puzzle of type-1 diabetes

For some time, scientists have known that a regenerative or repair process -- involving the development of specialized structures called tubular complexes -- is switched on during physical and chemical trauma to the pancreas (the gland that manufactures and secretes crucial insulin in the body).

27 Apr 2005

Number and quality of kidney transplants much greater if national matching program adopted

A collaboration between Johns Hopkins and Massachusetts Institute of Technology scientists has mathematically demonstrated that a national matching program for kidney paired donation, also called paired kidney exchange, would ensure the best possible kidney for the greatest number of recipients who have incompatible donors.

19 Apr 2005

Novel human kidney protein called renalase that regulates both heart contraction and blood pressure

Researchers at Yale School of Medicine and the VA Connecticut Healthcare System in West Haven identified a novel human kidney protein called renalase that regulates both heart contraction and blood pressure; it is a strong candidate for easily administered treatment of advanced kidney and cardiovascular disease.

10 Apr 2005

Largest "gene deserts" yet discovered in the human genome sequence

A detailed analysis of chromosomes 2 and 4 has detected the largest "gene deserts" known in the human genome and uncovered more evidence that human chromosome 2 arose from the fusion of two ancestral ape chromosomes, researchers supported by the National Human Genome Research Institute (NHGRI).

6 Apr 2005

Important link between kidney damage and cardiac problems

Scientists have identified an important link between kidney damage and cardiac problems, creating new possibilities for treating the primary cause of death in kidney disease patients.

29 Mar 2005

KCP protein protects kidneys from damage caused by chronic renal disease and injury

University of Michigan scientists have identified a new and unusual protein that reduces, in laboratory mice, kidney damage caused by chronic renal disease and acute toxic injuries.

28 Mar 2005

E. coli petting zoo link in Florida

A 12-year-old girl's death is being investigated for possible links to an outbreak of E. coli bacterial infections among people who attended one of two fairs in early March that included petting zoos, the Strawberry Festival in Plant City and the Central Florida Fair in Orlando.

28 Mar 2005

NASA scientists find clues about kidney disease

NASA scientists and academic colleagues are studying tiny hairs inside microorganisms to find clues about kidney disease.

8 Mar 2005

Mutations in newly discovered gene, NPHP5 cause Senior-Loken syndrome

Scientists at the University of Michigan Medical School have discovered a gene called NPHP5 and found mutations in this gene that cause a rare genetic disease called Senior-Loken syndrome. Children with this syndrome develop a type of cystic kidney disease called nephronophthisis, as well as a form of blindness called retinitis pigmentosa.

3 Mar 2005