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Scientists identify new molecular pathway that controls axonal degeneration following injury

Scientists identify new molecular pathway that controls axonal degeneration following injury

Axons connect neurons with each other to form the neural networks that underpin the vital functions of perception, motility, cognition, and memory. In many neurodegenerative disorders, from traumatic injury or toxic damage to diseases such as Alzheimer's or Parkinson's disease, axonal degeneration represents an essential pathological feature. [More]
Findings could lead to new therapeutic approach to Parkinson's disease

Findings could lead to new therapeutic approach to Parkinson's disease

E.. coli usually brings to mind food poisoning and beach closures, but researchers recently discovered a protein in E.. coli that inhibits the accumulation of potentially toxic amyloids--a hallmark of diseases such as Parkinson's. [More]
Research findings may lead to new treatment for hypothyroidism

Research findings may lead to new treatment for hypothyroidism

An international research team led by physician-scientists at Rush University Medical Center have gained new insights into hypothyroidism - a condition affecting about 10 million people in the U.S. - that may lead to new treatment protocols for the disease, particularly among the approximately 15 percent of patients for whom standard treatments are less effective. [More]
Biogen Idec, Columbia University Medical Center form $30 million genomics research alliance

Biogen Idec, Columbia University Medical Center form $30 million genomics research alliance

Biogen Idec and Columbia University Medical Center have formed a $30 million strategic alliance to conduct genetics discovery research on the underlying causes of disease and to identify new treatment approaches. As part of this agreement, a sequencing and analysis facility and shared postdoctoral program will be established at Columbia to support collaborative genetics studies. [More]
Man-made insulin nasal spray may improve memory in adults with Alzheimer's-related dementia

Man-made insulin nasal spray may improve memory in adults with Alzheimer's-related dementia

A man-made form of insulin delivered by nasal spray may improve working memory and other mental capabilities in adults with mild cognitive impairment and Alzheimer's disease dementia, according to a pilot study led by researchers at Wake Forest Baptist Medical Center. [More]
Research findings could lead to new drug design for neurological diseases

Research findings could lead to new drug design for neurological diseases

A new intermediate step and unexpected enzymatic activity in a metabolic pathway in the body, which could lead to new drug design for psychiatric and neurodegenerative diseases, has been discovered by researchers at Georgia State University. [More]
BrainStorm's phase 2a ALS study meets primary endpoint

BrainStorm's phase 2a ALS study meets primary endpoint

BrainStorm Cell Therapeutics Inc., a leading developer of adult stem cell technologies for neurodegenerative diseases, today announced positive final results from its phase 2a clinical trial of NurOwn™ in amyotrophic lateral sclerosis (ALS) patients, which enrolled 14 subjects at Hadassah Medical Center in Jerusalem. [More]
Spark Therapeutics files Form S-1 registration statement for initial public offering of common stock

Spark Therapeutics files Form S-1 registration statement for initial public offering of common stock

Spark Therapeutics announced today that it has filed a registration statement on Form S-1 with the U.S. Securities and Exchange Commission relating to the proposed initial public offering of its common stock. [More]
Novastem uses Stemedica's stem cell products to treat patient in ischemic stroke study

Novastem uses Stemedica's stem cell products to treat patient in ischemic stroke study

Novastem, a leader in regenerative medicine, announces the treatment of its first patient in its study for ischemic stroke at Clinica Santa Clarita. [More]
Clinatec chairman receives Lifetime Achievement Award for breakthrough research on Parkinson's disease

Clinatec chairman receives Lifetime Achievement Award for breakthrough research on Parkinson's disease

Prof. Alim-Louis Benabid, board chairman of Clinatec - The Edmond J. Safra Biomedical Research Center, received the Lifetime Achievement award on Dec. 13 from the North American Neuromodulation Society (NANS) for his work in developing deep brain stimulation to relieve symptoms in Parkinson’s disease patients. [More]
New technique allows rapid, large-scale studies of gene function

New technique allows rapid, large-scale studies of gene function

Using a gene-editing system originally developed to delete specific genes, MIT researchers have now shown that they can reliably turn on any gene of their choosing in living cells. [More]
Vaccinex completes VX15/2503 Phase 1 clinical trial in patients with advanced, refractory solid tumors

Vaccinex completes VX15/2503 Phase 1 clinical trial in patients with advanced, refractory solid tumors

Vaccinex, Inc. today announced the successful completion of a multicenter Phase 1, multiple ascending dose clinical trial of VX15/2503 anti-Semaphorin 4D (SEMA4D) antibody in 42 adult patients with advanced, refractory solid tumors. [More]
Researchers gain new insights into potential treatment for Alzheimer's disease

Researchers gain new insights into potential treatment for Alzheimer's disease

It is estimated that about 35 million people worldwide currently suffer from dementia and it is expected that the number will increase to 135 million by the year 2050. The disease is already one of the most common health problems in the elderly, which is why experts predict that the numbers of people affected will increase over time. [More]

Landmark call for neurodegenerative disease research

The EU Joint Programme - Neurodegenerative Disease Research has announced a EUR 30 million call for neurodegenerative disease research topped-up with EUR 10 million from the Horizon 2020 framework programme for research and innovation of the European Union. [More]
Drinking 3-5 cups of coffee per day may protect against Alzheimer’s Disease

Drinking 3-5 cups of coffee per day may protect against Alzheimer’s Disease

Drinking 3-5 cups of coffee per day may help to protect against Alzheimer’s Disease, according to research highlighted in an Alzheimer Europe session report published by the Institute for Scientific Information on Coffee, a not-for-profit organisation devoted to the study and disclosure of science related to coffee and health. [More]
Authors review current progress in developing transgenic pig models for human diseases

Authors review current progress in developing transgenic pig models for human diseases

Genetically engineered pigs, minipigs, and microminipigs are valuable tools for biomedical research, as their lifespan, anatomy, physiology, genetic make-up, and disease mechanisms are more similar to humans than the rodent models typically used in drug discovery research. [More]
Special receptor signalling mediates astrocytic hyperactivity in  Alzheimer's disease mouse model

Special receptor signalling mediates astrocytic hyperactivity in Alzheimer's disease mouse model

It has long been known that astrocytes change their shapes as a consequence of Alzheimer's. Cells located near the "plaques", as the protein deposits typical for this disease are called, grow in size and form additional extensions. [More]
Scientists unravel molecular mechanisms that drive ferroptosis signaling

Scientists unravel molecular mechanisms that drive ferroptosis signaling

Ferroptosis is a recently recognized form of regulated necrosis. Up until now, this form of cell death has only been thought to be a possible therapeutic approach to treat tumour cells. Yet, ferroptosis also occurs in non-transformed tissues as demonstrated by this study, thus implicating this cell death pathway in the development of a wide range of pathological conditions. More specifically, the deletion of the ferroptosis-regulating enzyme Gpx4 in a pre-clinical model results in high ferroptosis rates in kidney tubular epithelial cells causing acute renal failure. [More]
Stanford scientists explore how out-of-sync circadian clock impairs brain function

Stanford scientists explore how out-of-sync circadian clock impairs brain function

Anyone who has struggled with a foggy brain while adjusting to daylight saving time knows first-hand how an out-of-sync circadian clock can impair brain function. [More]
Scientists identify how ADAR1 gene mutation can lead to diseases

Scientists identify how ADAR1 gene mutation can lead to diseases

Scientists have discovered how a gene mutation can lead to diseases that occur when the immune system attacks the body by mistake. [More]