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Neuroscientists shed new light on how the brain works

Neuroscientists shed new light on how the brain works

Neuroscientists in Bonn and Heidelberg have succeeded in providing new insights into how the brain works. Researchers at the DZNE and the German Cancer Research Center analyzed tissue samples from mice to identify how two specific proteins, ‘CKAMP44’ and ‘TARP Gamma-8’, act upon the brain’s memory center. [More]
CanTx, Novogen name two key CMOs to manufacture clinical batches of anti-cancer drug Cantrixil

CanTx, Novogen name two key CMOs to manufacture clinical batches of anti-cancer drug Cantrixil

Oncology drug developer, CanTx Inc., and its parent company, Novogen Ltd., today announced that they have named two key contract manufacturing organizations (CMOs) to produce clinical batches of the experimental anti-cancer drug, Cantrixil. [More]
BU researchers find possible way to prevent Alzheimer's disease

BU researchers find possible way to prevent Alzheimer's disease

Boston University School of Medicine researchers may have found a way to delay or even prevent Alzheimer's disease (AD). They discovered that pre-treatment of neurons with the anti-aging protein Klotho can prevent neuron death in the presence of the toxic amyloid protein and glutamate. [More]
Autophagy prevents accumulation of toxic proteins associated with type 2 diabetes

Autophagy prevents accumulation of toxic proteins associated with type 2 diabetes

People with Type 2 diabetes have an excess of a protein called islet amyloid polypeptide, or IAPP, and the accumulation of this protein is linked to the loss of insulin-producing pancreatic beta cells. [More]

Study: Dementia carers may require more support with medication management

Family carers of people with dementia may need more support with medication management, according to a recent study. [More]
Study reveals novel epilepsy pathway linked to neurodegenerative diseases

Study reveals novel epilepsy pathway linked to neurodegenerative diseases

A recent scientific discovery showed that mutations in prickle genes cause epilepsy, which in humans is a brain disorder characterized by repeated seizures over time. However, the mechanism responsible for generating prickle-associated seizures was unknown. [More]

Researchers identify molecular mechanisms of cognitive decline using high-throughput proteomics

From telephone numbers to foreign vocabulary, our brains hold a seemingly endless supply of information. However, as we are getting older, our ability to learn and remember new things declines. [More]
Study finds microglia increase neuronal firing and enhance brain cell survival after injury

Study finds microglia increase neuronal firing and enhance brain cell survival after injury

A type of immune cell widely believed to exacerbate chronic adult brain diseases, such as Alzheimer's disease and multiple sclerosis (MS), can actually protect the brain from traumatic brain injury (TBI) and may slow the progression of neurodegenerative diseases, according to Cleveland Clinic research published today in the online journal Nature Communications. [More]
Researchers identify group of cells in brain that plays important role in Down syndrome

Researchers identify group of cells in brain that plays important role in Down syndrome

Researchers from UC Davis School of Medicine and Shriners Hospitals for Children - Northern California have identified a group of cells in the brain that they say plays an important role in the abnormal neuron development in Down syndrome. [More]
Deadly neurodegenerative disease treated in worms gives hope for humans

Deadly neurodegenerative disease treated in worms gives hope for humans

An untreatable and deadly neurodegenerative disease has been modelled and treated in worms by University of Liverpool researchers, suggesting a cure could be found for humans. [More]
Sleep problems in PD patients can worsen in later stages of disease

Sleep problems in PD patients can worsen in later stages of disease

Up to 70% of Parkinson's disease (PD) patients experience sleep problems that negatively impact their quality of life. [More]
New study sheds light on role of RPM-1 protein in neuron development

New study sheds light on role of RPM-1 protein in neuron development

In a new study, scientists from the Florida campus of The Scripps Research Institute have shed new light on these complex processes, showing that a particular protein plays a far more sophisticated role in neuron development than previously thought. [More]
Clinicians launches ACEmobile app to support assessment of dementia

Clinicians launches ACEmobile app to support assessment of dementia

A team of clinicians from Plymouth, UK, and Sydney, Australia, have today (Wednesday 9th July 2014 UK, Thursday 10th July Australia) launched ACEmobile - a free-to-use app to support the assessment of dementia, worldwide. [More]
MEF2 gene: A potential therapeutic target to protect neuronal loss in Alzheimer's, Parkinson's

MEF2 gene: A potential therapeutic target to protect neuronal loss in Alzheimer's, Parkinson's

A new study by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) has identified a chemical "switch" that controls both the generation of new neurons from neural stem cells and the survival of existing nerve cells in the brain. [More]
Researchers identify pathogenic mechanism common to several neurodegenerative diseases

Researchers identify pathogenic mechanism common to several neurodegenerative diseases

An international team of researchers identified a pathogenic mechanism that is common to several neurodegenerative diseases. The findings suggest that it may be possible to slow the progression of dementia even after the onset of symptoms. [More]
Persons with reduced levels of TREM2 protein at greater risk for neurodegenerative diseases

Persons with reduced levels of TREM2 protein at greater risk for neurodegenerative diseases

Persons with reduced levels of the TREM2 protein could be at greater risk of developing neurodegenerative diseases such as Alzheimer's disease or frontotemporal dementia, according to an international study which included the participation of the Universitat Autònoma de Barcelona and the Sant Pau Biomedical Research Institute. [More]

Short sleep linked to cognitive decline in older adults

Researchers at Duke-NUS Graduate Medical School Singapore (Duke-NUS) have found evidence that the less older adults sleep, the faster their brains age. [More]

Scientists one step closer to understanding the causes of Parkinson's disease

Scientists have taken a step closer to understanding the causes of Parkinson's disease, identifying what's happening at a cellular level to potentially help develop future treatments. [More]
Study reveals that inflammasomes remain active even after cell death

Study reveals that inflammasomes remain active even after cell death

Even after a cell dies, components of the immune system remain active and continue to fuel inflammatory reactions. [More]
Alternative disposal process in optic nerve cells has implications for neurodegenerative diseases

Alternative disposal process in optic nerve cells has implications for neurodegenerative diseases

Biologists have long considered cells to function like self-cleaning ovens, chewing up and recycling their own worn out parts as needed. [More]