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Nicotine is an alkaloid found in the nightshade family of plants (''Solanaceae'') which constitutes approximately 0.6–3.0% of dry weight of tobacco, with biosynthesis taking place in the roots, and accumulating in the leaves.
Penn investigators explore new treatment option for cocaine dependence

Penn investigators explore new treatment option for cocaine dependence

In the ongoing fight against drug addiction, researchers from the University of Pennsylvania's School of Nursing and Perelman School of Medicine have discovered a unique application for an FDA-approved drug currently used for obese patients and type 2 diabetics: treatment for cocaine dependence. [More]
Cherry-flavoured e-cigarette users may be exposed to potentially harmful chemical

Cherry-flavoured e-cigarette users may be exposed to potentially harmful chemical

An analysis of 145 different electronic-cigarette flavoring products reveals that many e-cigarette users may be exposed to a potentially harmful chemical. In a research letter published online today in the peer-reviewed journal Thorax, a research team led by Maciej Goniewicz, PhD, PharmD, of Roswell Park Cancer Institute reports that high levels of the respiratory irritant benzaldehyde were detected in the vapor from most of the flavored nicotine products they studied, with the highest concentrations in vapor from cherry-flavored products. [More]
Researchers developing new methods to better analyze effects of e-cig flavorings

Researchers developing new methods to better analyze effects of e-cig flavorings

Faculty and student researchers at Rochester Institute of Technology's National Technical Institute for the Deaf are developing methods to better analyze the effects of flavorings used in electronic cigarettes (e-cigs). [More]
Second-hand smoke exposure linked to larger waist, poorer cognition in children

Second-hand smoke exposure linked to larger waist, poorer cognition in children

Exposure to second-hand smoke is associated with a larger waist and poorer cognition in children, researchers say. [More]
Indoor air quality in hospitality venues that allow smoking is worse than outdoor, study finds

Indoor air quality in hospitality venues that allow smoking is worse than outdoor, study finds

Research carried out in six cities with dangerous levels of air pollution indicates that air quality inside venues that allow smoking is even worse than outdoors. [More]
Study shows regular caffeine consumption does not lead to extra heartbeats

Study shows regular caffeine consumption does not lead to extra heartbeats

Contrary to current clinical belief, regular caffeine consumption does not lead to extra heartbeats, which, while common, can lead in rare cases to heart- or stroke-related morbidity and mortality, according to UC San Francisco researchers. [More]
E-cigarettes suppress immune defenses, alter inflammation and boost bacterial virulence

E-cigarettes suppress immune defenses, alter inflammation and boost bacterial virulence

Researchers at the University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System report data suggesting that e-cigarettes are toxic to human airway cells, suppress immune defenses and alter inflammation, while at the same time boosting bacterial virulence. [More]
TSRI scientists discover molecular ‘switch’ that could reduce nicotine addiction

TSRI scientists discover molecular ‘switch’ that could reduce nicotine addiction

Scientists at The Scripps Research Institute have discovered that a lipid in brain cells may act as a “switch” to increase or decrease the motivation to consume nicotine. [More]
Adult smokers who use e-cigarettes 28% less likely to quit smoking

Adult smokers who use e-cigarettes 28% less likely to quit smoking

Electronic cigarettes are widely promoted and used to help smokers quit traditional cigarettes, but a new analysis from UC San Francisco found that adult smokers who use e-cigarettes are actually 28 percent less likely to stop smoking cigarettes. [More]
Topiramate drug curbs marijuana use among young smokers, but with serious side effects

Topiramate drug curbs marijuana use among young smokers, but with serious side effects

Combining the drug topiramate with psychological counseling curbed marijuana use among young smokers significantly more than did counseling alone, according to newly published results of a small randomized, controlled trial at Brown University. The results come with a caveat, however: many study volunteers couldn't tolerate the medicine's side effects. [More]

Teens who rate e-cigarettes ads as effective more likely to try them in the future

Adolescents are more likely to say they will try electronic cigarettes if they perceive TV ads for these products as effective, according to a new study by RTI International researchers. [More]
Small differences in specific genetic variant could alter nicotine consumption

Small differences in specific genetic variant could alter nicotine consumption

Nicotine is an addictive substance and genetic factors are known to play a role in smoking behaviors. Recently, a team of researchers at Penn State and the University of Colorado determined how small differences in a particular region of the mouse genome can alter nicotine consumption. [More]
E-cigarettes share similar short-term safety profile as Nicorette products

E-cigarettes share similar short-term safety profile as Nicorette products

A new study, published in the Journal of Regulatory Toxicology and Pharmacology, found that e-cigarettes share a similar short-term safety profile as Nicorette products and are comparable in reducing tobacco withdrawal symptoms. [More]
Nearly 7 in 10 middle and high school students exposed to e-cigarette ads

Nearly 7 in 10 middle and high school students exposed to e-cigarette ads

About 7 in 10 middle and high school students – more than 18 million young people – see e-cigarette advertising in stores, online, in newspapers and magazines, or on television and in movies, according to a new CDC Vital Signs report. [More]
SDSU researchers explore ways to eradicate thirdhand smoke

SDSU researchers explore ways to eradicate thirdhand smoke

When cigarette smoke is blown into the environment, its chemical constituents don't just vanish into thin air. Residue from the smoke settles into, accumulates and is stored in the surrounding environment, such as upholstery, carpets, walls, clothing and curtains. [More]
E-cigarettes damage cells in ways that could lead to cancer

E-cigarettes damage cells in ways that could lead to cancer

Adding to growing evidence on the possible health risks of electronic cigarettes, a lab team at the Veterans Affairs San Diego Healthcare System tested two products and found they damaged cells in ways that could lead to cancer. The damage occurred even with nicotine-free versions of the products. [More]
Enteric nerves of irritable bowel syndrome patients respond poorly to inflammatory substances

Enteric nerves of irritable bowel syndrome patients respond poorly to inflammatory substances

For the first time, biopsies of patients with irritable bowel syndrome have shown that the nerves in their gut wall respond poorly to a cocktail of inflammatory substances. This refutes the previous theory that patients with irritable bowel syndrome have an overly sensitive gut. [More]
Teens with moderate mental health problems vape e-cigarettes

Teens with moderate mental health problems vape e-cigarettes

Teenagers with moderate mental health problems who may not have considered smoking conventional cigarettes are turning to electronic cigarettes, a new USC study has found. [More]
Drug use remains stable among teens, MTF survey shows

Drug use remains stable among teens, MTF survey shows

The 2015 Monitoring the Future survey (MTF) shows decreasing use of a number of substances, including cigarettes, alcohol, prescription opioid pain relievers, and synthetic cannabinoids ("synthetic marijuana"). Other drug use remains stable, including marijuana, with continued high rates of daily use reported among 12th graders, and ongoing declines in perception of its harms. [More]
CAMH survey finds risky drinking behaviour among Ontario students

CAMH survey finds risky drinking behaviour among Ontario students

Alcohol remains the most popular drug of choice for Ontario students in grades 7 through 12, with 29 percent of 12th graders engaging in hazardous drinking, according to the 2015 Ontario Student Drug Use and Health Survey (OSDUHS) released today by the Centre for Addiction and Mental Health. [More]
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