Nitric Oxide News and Research

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Research shows a correlation between air pollution and heart attacks in non-smokers

Research presented at ESC Congress 2022 supports a causal relationship between air pollution and heart attacks since smokers, who already inhale smoke, were unaffected by dirty air.

23 Aug 2022

Interferon beta reduces binding of three components to RBCs, study finds

Drugs called interferon betas are common treatments for multiple sclerosis (MS), reducing relapses and slowing motor function decline. Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce proinflammatory molecules and even increase production of anti-inflammatory species in MS patients.

11 Aug 2022

Research paves the way for therapies to treat or delay preterm labor

Researchers have identified a cause of preterm labor, an enigma that has long challenged researchers. New research published in The Journal of Physiology suggests a protein, called Piezo1, is responsible for regulating the behavior of the uterus.

9 Aug 2022

Microvascular disease and Alzheimer's associated with more white matter damage, more inflammation

Disease of the microscopic blood vessels that feed the white matter of our brain is associated with worse cognitive function and memory deficits in individuals with Alzheimer's, scientists report.

2 Aug 2022

Carbon monoxide foam in the fight against inflammation

News-Medical speaks to Leo Otterbein about a novel way to deliver carbon monoxide to the body while bypassing its potentially hazardous effects.

2 Aug 2022

How COVID-19 affects the brain microvasculature

A recent study discusses the effects of COVID-19 on the brain microvascular system.

25 Jul 2022

Does high-dose inhaled nitric oxide improve respiratory function and outcomes among pregnant patients hospitalized with severe COVID-19 pneumonia?

Researchers demonstrated that inhaled nitric oxide 200 (iNO200) enhances oxygenation in pregnant COVID-19 patients with severe pneumonia.

13 Jul 2022

Nitric oxide use in cardiopulmonary bypass surgery does not improve the recovery of children

Infants undergoing heart surgery are connected to a heart-lung machine and given nitric oxide as an anti-inflammatory.

27 Jun 2022

C-reactive protein levels predict ED risk

A recent meta-analysis aimed to describe the relationship between C-reactive protein levels and erectile dysfunction.

27 Jun 2022

Midgestation increase in leptin puts child and mother at risk of cardiovascular disease

Before a baby is ever born, critical supply chain problems with nutrition and oxygen can result in premature birth or even death and increase the child and mother's lifelong risk of cardiovascular disease.

23 Jun 2022

Potential applications of bioactive molecules present in fruit peels

A recent study published in Current Issues in Molecular Biology reviewed the potential biological applications of fruit peel extracts.

13 Jun 2022

The link between androgens and COVID-19

A new paper examines the association between androgens and COVID-19, as revealed by the research carried out on this topic throughout the pandemic.

20 May 2022

Patients with COVID-19 pneumonitis and moderate to severe ARDS treated with sildenafil

A new study published in the British Journal of Anaesthesia aimed to determine whether sildenafil could improve gaseous exchange in patients with COVID-19 ARDS with pulmonary hypertension, RV dysfunction, or both.

17 May 2022

Researchers demonstrate link between high-fat diet, nitric oxide levels and cancer development

It has long been hypothesized that dietary habits can precede and even exacerbate the development of cancer.

17 May 2022

Novel therapy using nitric oxide may be an efficient and safe way to treat multiple metabolic diseases

A novel therapy developed at the University of Alabama at Birmingham ameliorates obesity and Type 2 diabetes in mice fed a high-fat diet.

29 Apr 2022

Understanding sex differences in the pathophysiology of SARS-CoV-2 infection

A recent study published in the journal Immunology analyzed whether sex mattered in the immune response to SARS-CoV-2.

29 Apr 2022

A cigarette smoke compound affects cartilage homeostasis

Cigarette smoke has been shown to deleteriously affect human health. For example, degenerative disc diseases are increasingly linked to cigarette smoking.

28 Apr 2022

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

In a recent study posted to the bioRxiv* preprint server, researchers developed aminoadamantane nitrates compounds that inhibit the ion channels formed by the envelope (E) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and enable targeted drug delivery of nitric oxide (NO)-related group for S-nitrosylation of host angiotensin-converting enzyme 2 (ACE2), which would inhibit ACE2 binding with the viral spike (S) protein and thereby inhibit viral replication in the host.

11 Apr 2022

Study reveals how pancreatic tumors program macrophages to construct fibrotic barriers

In the presence of pancreatic tumors, certain immune cells break down structural proteins into molecules that trigger the building of dense tissue, a known barrier to therapy, a new study finds.

4 Apr 2022

Cell stress-related biochemical events may be partly driving Parkinson's disease

Parkinson's disease may be driven in part by cell stress-related biochemical events that disrupt a key cellular cleanup system, leading to the spread of harmful protein aggregates in the brain, according to a new study from scientists at Scripps Research.

23 Feb 2022