Oligonucleotides News and Research

RSS

Oligonucleotides are short sequences of nucleotides (RNA or DNA), typically with twenty or fewer bases. Automated synthesizers allow the synthesis of oligonucleotides up to 160 to 200 bases.

New therapeutic approach for Parkinson’s and other neurodegenerative diseases

Xiang-Dong Fu, PhD, has never been more excited about something in his entire career. He has long studied the basic biology of RNA, a genetic cousin of DNA, and the proteins that bind it. But a single discovery has launched Fu into a completely new field: neuroscience.

25 Jun 2020

Tumor cell–based vaccine may prevent relapse of mantle cell lymphoma

A phase I/II clinical trial by researchers at Stanford University suggests that vaccines prepared from a patient's own tumor cells may prevent the incurable blood cancer mantle cell lymphoma (MCL) from returning after treatment.

22 Jun 2020

Mapping RNA sequences of therapeutic value in the SARS-CoV-2 genome

Now, in new research published on the preprint server bioRxiv European scientists have performed RNA structure probing to obtain a single-base resolution secondary structure map of the full SARS-CoV-2 coronavirus genome.

17 Jun 2020

AFFiRiS announces preclinical results of monoclonal antibody mAB C6-17 in Huntington's

AFFiRiS, a clinical-stage biotechnology company developing novel disease-modifying specific active immunotherapies, today announced that detailed preclinical results with its monoclonal antibody mAB C6-17 to treat Huntington's Disease were published in the peer-reviewed journal Neurobiology of Disease.

3 Jun 2020

IDT opens new manufacturing facility to expand capacity of COVID-19 products

Integrated DNA Technologies, a leading comprehensive genomics solutions provider, announced the opening of its new manufacturing facility located in the Research Triangle Park in North Carolina.

From Integrated DNA Technologies 18 May 2020

Scientists gain new insight into the pathological mechanisms behind two neurodegenerative diseases

An international team led by Emory scientists has gained insight into the pathological mechanisms behind two devastating neurodegenerative diseases.

6 May 2020

Horizon Discovery and Pharmahungary report positive early-stage results for novel micro-RNA therapeutic for ischemic heart diseases

Horizon Discovery Group plc and Pharmahungary Group announced positive early-stage results for a novel micro-RNA therapeutic for ischemic heart diseases.

31 Mar 2020

New partnership aims to explore, cultivate innovations in cell and gene therapy

Some patients who have not responded to traditional medicines are now experiencing remarkable recoveries thanks to next-generation immunotherapies. These therapies equip a patient's own immune cells to recognize, target, and destroy cancer cells.

25 Nov 2019

Potential new therapy for progeria

Aging is a complex and natural process that affects all living organisms. As people age, normal biological processes are affecting, resulting in a decline in various organs and age-related conditions. Though aging is normal, some children affected by a disease called Progeria may age way faster than others.

18 Nov 2019

LSU Health New Orleans awarded $1.74 million to advance research on Usher syndrome

Jennifer J. Lentz, PhD, Associate Professor at LSU Health New Orleans Neuroscience Center of Excellence and Departments of Otorhinolaryngology, Genetics and Ophthalmology, in collaboration with Robert K. Koenekoop MD, PhD and Professor of Pediatric Surgery, Human Genetics and Ophthalmology at McGill University in Montreal, Quebec, Canada, has been awarded a $1.74 million USD grant to advance research on Usher syndrome.

22 Oct 2019

Pluripotent stem cells help advance understanding of how Huntington's disease develops

Huntington's disease (HD) is a fatal hereditary disease for which there is no cure. A novel study from Cedars-Sinai Medical Center, Los Angeles, using pluripotent stem cells advances understanding of how the disease develops and may help pave the way for identifying pathways for future treatments.

21 Oct 2019

Researchers develop customized drug treatment to bypass patient’s unique mutation

An unprecedented case at Boston Children's Hospital shows that it's possible to do something that's never been done before: identify a patient's unique mutation, design a customized drug to bypass it, manufacture and test the drug, and obtain permission from the Food and Drug Administration (FDA) to begin treating the patient -- all in less than one year.

11 Oct 2019

Spatial Gene Expression Profiling of Neurological Disorders

In this interview, Cedric Uytingco discusses the key benefits of being able to visualize gene expression patterns in neurological samples.

From 10x Genomics, Inc. 7 Oct 2019

Experimental treatment shows early promise to help nearly half of DMD patients

A new therapeutic being tested by University of Alberta researchers is showing early promise as a more effective treatment that could help nearly half of patients with Duchenne muscular dystrophy.

25 Sep 2019

Promising new drug being developed for polycystic kidney disease

Researchers have developed a potential new drug for the treatment of Polycystic kidney disease (PKD) – a deadly genetic condition affecting the kidneys that leads to formation of swellings or cysts within the kidney that cause it to fail.

12 Sep 2019

Breast cancer gene could be key to developing targeted therapy for hepatoblastoma

Hepatoblastoma is a rare form of liver cancer affecting just a few individuals per million. However, it is the leading cause of liver cancer in infants and young children, with most patients diagnosed before their third birthday.

4 Sep 2019

IDT launches high quality, ready-to-use custom oligo pools

Continuing its mission to advance biological research worldwide, Integrated DNA Technologies has launched oPools Oligo Pools – ready-to-use pools of high quality DNA oligonucleotides (oligos) up to 350 nucleotides in length.

From Integrated DNA Technologies 16 Aug 2019

Prion disease in mice treated successfully with antisense oligonucleotides

Prion proteins are known to cause scrapie – a neurodegenerative condition. It is capable of debilitating damage to the nervous system. Researchers have successfully devised a treatment for this condition which prolonged the lives of the lab mice infected with the prions.

1 Aug 2019

HDO-antimiR could be a potent weapon to combat microRNA-related disease

MicroRNA (miRNA) is a type of RNA that plays an important role in various cellular processes and is also involved in developing defenses against pathogens. Increasing numbers of studies have indicated that certain human diseases are caused by altered expression and organization of miRNA.

27 Jul 2019

IDT and 3CR team up to widen access to custom solutions for genotyping screening

In the latest collaboration in a series to advocate for genomics research, Integrated DNA Technologies is teaming up with 3CR Bioscience to widen access to quality custom solutions for genotyping screening.

From Integrated DNA Technologies 3 Jul 2019