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An opioid is a chemical that works by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract. The receptors in these two organ systems mediate both the beneficial effects and the side effects of opioids.
Minister Ambrose calls for proposals to tackle prescription drug abuse

Minister Ambrose calls for proposals to tackle prescription drug abuse

The Honourable Rona Ambrose, Minister of Health, today issued a national Call for Proposals to improve the prescribing practices for prescription drugs that have a high risk of abuse or addiction. [More]
FDA approves Targiniq ER to treat severe pain

FDA approves Targiniq ER to treat severe pain

Today, the U.S. Food and Drug Administration approved Targiniq ER (oxycodone hydrochloride and naloxone hydrochloride extended-release tablets), an extended-release/long-acting (ER/LA) opioid analgesic to treat pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. [More]
Telecare approach improves chronic musculoskeletal pain management

Telecare approach improves chronic musculoskeletal pain management

A collaborative care approach delivered by telephone is effective for managing chronic musculoskeletal pain, show findings from the Stepped Care to Optimize Pain Care Effectiveness study. [More]
Viewpoints: GOP's 'cynical' lawsuit against Obama; debt crisis is not over

Viewpoints: GOP's 'cynical' lawsuit against Obama; debt crisis is not over

There's not much that Republicans like about the 2010 Affordable Care Act, but one thing they particularly dislike is the requirement that employers with 50 or more full-time workers provide comprehensive health insurance. [More]
New study finds highest rates of decline in prescription drug misuse nationwide

New study finds highest rates of decline in prescription drug misuse nationwide

Five states that have implemented multi-faceted prescription drug abuse prevention programs in recent years showed the highest rate of decline in prescription drug misuse rates nationwide, according to a new study issued today by Quest Diagnostics, the world's leading provider of diagnostic information services. [More]
Once-a-day pill for patients experiencing opioid-induced constipation

Once-a-day pill for patients experiencing opioid-induced constipation

Opioids - strong morphine-based painkillers - are widely prescribed to patients experiencing chronic severe pain. While these drugs are very effective for treating and managing pain, they have one particularly bothersome side effect: constipation. [More]
Telecare intervention leads to improvement in chronic musculoskeletal pain

Telecare intervention leads to improvement in chronic musculoskeletal pain

A telephone-delivered intervention, which included automated symptom monitoring, produced clinically meaningful improvements in chronic musculoskeletal pain compared to usual care, according to a study in the July 16 issue of JAMA. [More]
Pennsylvania releases statewide guidelines on use of prescription opioids for chronic non-cancer pain

Pennsylvania releases statewide guidelines on use of prescription opioids for chronic non-cancer pain

On behalf of Governor Tom Corbett, the Pennsylvania Departments of Drug and Alcohol Programs and Health, in partnership with the Pennsylvania Medical Society, today released statewide guidelines to address the use of prescription opioids to treat chronic non-cancer pain. [More]
Kaleo announces U.S. availability of EVZIO for emergency treatment of opioid overdose

Kaleo announces U.S. availability of EVZIO for emergency treatment of opioid overdose

Kaleo, a privately-held pharmaceutical company headquartered in Richmond, Virginia, today announced the United States (U.S.) commercial availability of EVZIO for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression. [More]
State highlights: N.Y. legalizes medical marijuana; La. Medicaid paid for ineligible inmate care; Md. checking Medicaid rolls for unqualified

State highlights: N.Y. legalizes medical marijuana; La. Medicaid paid for ineligible inmate care; Md. checking Medicaid rolls for unqualified

New York on Monday became the 23rd state to legalize certain forms of marijuana for medical reasons as Gov. Andrew Cuomo signed legislation into law at an event in Manhattan. The measure, which passed both houses of the legislature during the final moments of the legislative session, in June, is significantly more restrictive than other medical-marijuana laws in the nation (Orden, 7/7). [More]
State highlights: N.C. lawmakers reach Medicaid agreement; Idaho asks SCOTUS to take up Medicaid reimbursement

State highlights: N.C. lawmakers reach Medicaid agreement; Idaho asks SCOTUS to take up Medicaid reimbursement

For the past few weeks, two big issues have kept the two chambers of the General Assembly from reaching an agreement on next year's state budget: teacher salaries and Medicaid. But on Wednesday, the Senate and the House of Representatives finally moved closer to agreement on their Medicaid forecasts, loosening a logjam that's kept legislators in Raleigh past July 1, the beginning of the fiscal year (Hoban, 7/3). [More]

Prescription drug deaths drop in Fla. after crackdown on doctors

Deaths involving narcotic painkillers dropped 26 percent over two years in Florida after stricter doctor scrutiny, according to a report from the federal Centers for Disease Control and Prevention. [More]
Targeting ASIC-related neurotransmission may lead to new therapies for treating drug addiction

Targeting ASIC-related neurotransmission may lead to new therapies for treating drug addiction

University of Iowa researchers have discovered a new form of neurotransmission that influences the long-lasting memory created by addictive drugs, like cocaine and opioids, and the subsequent craving for these drugs of abuse. Loss of this type of neurotransmission creates changes in brains cells that resemble the changes caused by drug addiction. [More]
Trevena's Phase 1b data for TRV130 published in the journal Pain

Trevena's Phase 1b data for TRV130 published in the journal Pain

Trevena, Inc., a clinical stage biopharmaceutical company and the leader in the discovery of G protein coupled receptor (GPCR) biased ligands, today announced the publication of its Phase 1b data for TRV130 in the journal Pain. [More]
BioLineRx announces in-licensing of BL-1110 compound for treatment of neuropathic pain

BioLineRx announces in-licensing of BL-1110 compound for treatment of neuropathic pain

BioLineRx Ltd., a clinical-stage biopharmaceutical company dedicated to identifying, in-licensing and developing promising therapeutic candidates, announced today it has in-licensed BL-1110, a novel compound for the treatment of neuropathic pain. [More]
Trevena reports positive results from TRV734 Phase 1 trial for treating acute/chronic pain

Trevena reports positive results from TRV734 Phase 1 trial for treating acute/chronic pain

Trevena, Inc. (NASDAQ:TRVN) today announced positive results from its Phase 1 trial of TRV734, which Trevena is developing with the goal of providing improved analgesia while avoiding gastrointestinal and respiratory side effects typically associated with opioids. [More]
Physician describes ways to combat post-cancer pain

Physician describes ways to combat post-cancer pain

More and more people are surviving their cancer. Unfortunately, sometimes survival can come with pain. Although many people won't feel any pain after their cancer treatment, some may have chronic, bothersome pain. [More]
Researchers find sharp increase in deaths from commonly prescribed painkillers in US, Canada

Researchers find sharp increase in deaths from commonly prescribed painkillers in US, Canada

The number of deaths involving commonly prescribed painkillers is higher than the number of deaths by overdose from heroin and cocaine combined, according to researchers at McGill University. [More]
Use of opioid linked to higher levels of dissatisfaction following spine surgery

Use of opioid linked to higher levels of dissatisfaction following spine surgery

A new study appearing in the Journal of Bone and Joint Surgery (JBJS) links the use of opioid pain relievers (prescription medications, such as Percocet) to less improvement and higher levels of dissatisfaction following spine surgery. [More]
8.5 million on Medicare get opioids

8.5 million on Medicare get opioids

The number of senior citizens getting narcotic painkillers and anti-anxiety medications under Medicare's prescription drug program is climbing sharply, and those older patients are being put on the drugs for longer periods of time, a USA TODAY examination of federal data shows. [More]