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Chromosome X microduplications implicated in infancy-onset gigantism

Chromosome X microduplications implicated in infancy-onset gigantism

Researchers report that heritable microduplications on chromosome Xq26.3 may underlie a “striking” form of gigantism with onset in late infancy, and reveal a candidate culprit gene. [More]
Single biopsy site may reveal all lung adenocarcinoma genetic mutations

Single biopsy site may reveal all lung adenocarcinoma genetic mutations

Genetic sequencing of a single tumour site sample may be adequate for identifying cancer gene mutations in patients with lung andenocarcinoma, research published in Science suggests. [More]
Older adults participating in hospital-based exercise program report less pain, stiffness and fatigue

Older adults participating in hospital-based exercise program report less pain, stiffness and fatigue

It may seem counterintuitive, but exercise can be beneficial for people suffering from arthritis and other muscle and joint conditions. A new study at Hospital for Special Surgery finds that older adults experienced less pain, reduced stiffness and less fatigue after participating in a hospital-based exercise program. [More]
Metastatic lung cancer outcomes independent of KRAS mutation subtypes

Metastatic lung cancer outcomes independent of KRAS mutation subtypes

Overall survival in patients with metastatic lung cancer does not correlate with Kirsten rat sarcoma viral oncogene homologue mutation subtypes, US researchers report. [More]
First-line dacomitinib may improve advanced NSCLC survival

First-line dacomitinib may improve advanced NSCLC survival

Preliminary research suggests that the second-generation tyrosine kinase inhibitor dacomitinib may improve progression-free survival in patients with advanced non-small-cell lung cancer with epidermal growth factor receptor mutations. [More]
PD-L1 expression tied to favourable prognosis in SCLC

PD-L1 expression tied to favourable prognosis in SCLC

Programmed death-ligand 1 is expressed by around 70% of small-cell lung cancers and is associated with favourable patient outcomes, Japanese researchers report. [More]
Molecular response criteria examined for CML

Molecular response criteria examined for CML

The limitations in determining molecular response in patients with chronic myeloid leukaemia treated with tyrosine kinase inhibitor therapy have been reviewed in Cancer. [More]
PD-1, PD-L1 differentially expressed in NSCLC

PD-1, PD-L1 differentially expressed in NSCLC

The expression of the immune checkpoint protein programmed death-1 receptor and its ligand varies according to tumour and patient characteristics in oncogene-addicted non-small-cell lung cancer, research indicates. [More]
SI-BONE wins Gold 2014 International MarCom Award for SI Joint Patient Community website

SI-BONE wins Gold 2014 International MarCom Award for SI Joint Patient Community website

SI-BONE, Inc., a medical device company that pioneered the use of the iFuse Implant System, a minimally invasive surgical (MIS) device indicated for fusion for certain disorders of the sacroiliac (SI) joint, won the Gold 2014 International MarCom Award for its SI Joint Patient Community website and an Honorable Mention for the SI Buddy Patient Networking Program. [More]
Good Samaritan Hospital receives $417,560 grant to implement telemedicine program

Good Samaritan Hospital receives $417,560 grant to implement telemedicine program

The U.S. Department of Agriculture (USDA) Rural Development awards Good Samaritan Hospital, a prominent downtown Los Angeles hospital, a $417,560 grant to implement a telemedicine program that will connect members of the medical staff at Good Samaritan Hospital with public health and primary care providers and their patients at six Public Health sites on the island of Guam. [More]
Current evidence does not support routine minimally invasive disc surgery, say researchers

Current evidence does not support routine minimally invasive disc surgery, say researchers

McMaster University researchers have found that current evidence does not support the routine use of minimally invasive surgery to remove herniated disc material pressing on the nerve root or spinal cord in the neck or lower back. [More]
Early support and education program has positive impact on people with rheumatoid arthritis

Early support and education program has positive impact on people with rheumatoid arthritis

A study at Hospital for Special Surgery finds that a support group addressing the psychological and educational needs of people recently diagnosed with rheumatoid arthritis (RA) has a strong positive impact on their lives. [More]
Auxilium Pharmaceuticals presents STENDRA clinical data for ED treatment at SMSNA Scientific Meeting

Auxilium Pharmaceuticals presents STENDRA clinical data for ED treatment at SMSNA Scientific Meeting

Auxilium Pharmaceuticals, Inc., a specialty biopharmaceutical company, today announced that data were presented regarding the use of STENDRA® (avanafil) tablets for the treatment of erectile dysfunction (ED) at the 20th Annual Fall Scientific Meeting of the Sexual Medicine Society of North America (SMSNA) held in Miami from November 20-23, 2014. [More]
EvergreenHealth, Valley General Hospital approve final phase of alliance agreement

EvergreenHealth, Valley General Hospital approve final phase of alliance agreement

EvergreenHealth and Valley General Hospital announced today that their respective Boards of Commissioners have voted to approve the third and final phase of an alliance agreement in which Valley General Hospital in Monroe, Washington will become part of the Kirkland-based health care system and managed by EvergreenHealth. [More]
Biomarker-directed chemotherapy detrimental in NSCLC

Biomarker-directed chemotherapy detrimental in NSCLC

Treating non-small-cell lung cancer patients with chemotherapy customised according to expression of BRCA1 and receptor-associated protein 80 does not improve progression-free survival compared with nonselected, cisplatin-based chemotherapy, show study findings. [More]
BMI plays role in rheumatoid arthritis patients' ability to achieve sustained remission

BMI plays role in rheumatoid arthritis patients' ability to achieve sustained remission

A study by Hospital for Special Surgery researchers finds that body mass index (BMI) plays a role in rheumatoid arthritis (RA) patients' ability to achieve a sustained remission. Looking at patients who had received an RA diagnosis within the past 12 months, investigators found that those who were significantly underweight or overweight/obese were the least likely to remain in remission. [More]
Total hip replacement: An excellent option for younger patients with juvenile idiopathic arthritis

Total hip replacement: An excellent option for younger patients with juvenile idiopathic arthritis

When you think of hip replacement surgery, you generally envision an older adult with painful osteoarthritis. But the procedure is also used for younger patients with juvenile idiopathic arthritis (JIA) whose joints have been severely damaged by the disease. [More]
Load bearing, biodegradable implants can reduce the number of second surgeries

Load bearing, biodegradable implants can reduce the number of second surgeries

No other joint in the human body is as highly mobile as is the shoulder. However, it is also very sensitive and prone to injury, with athletes being particularly affected. [More]
Sutter Health network hospitals recognized as ‘Top Performers on Key Quality Measures’

Sutter Health network hospitals recognized as ‘Top Performers on Key Quality Measures’

For the fourth year, The Joint Commission, the nation's leading accreditor of health care organizations, recognized hospitals in the Sutter Health network as among the nation's Top Performers on Key Quality Measures®. Sutter Health-affiliated hospitals have earned these quality recognitions each year since the program began in 2011. [More]
Bevacizumab–erlotinib combined efficacy may depend on VEGF level

Bevacizumab–erlotinib combined efficacy may depend on VEGF level

Bevacizumab may enhance the antitumour activity of erlotinib by increasing the intratumoural concentration of erlotinib in some non-small-cell lung cancers expressing high levels of vascular endothelial growth factor, Japanese researchers report. [More]