PDE News and Research

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Association of genetically proxied PDE5 inhibition with measures of fertility, sexual behavior, and wellbeing

Researchers performed a two-sample Mendelian randomization analysis to investigate the associations between genetically proxied suppression of PDE5, a recognized pharmacological target for erectile dysfunction, fertility, subjective wellness, and sexual behavior.

14 Dec 2023

Charting the future of IBD treatment: From immune modulators to microRNA therapies

In a recent study published in the journal eGastroenterology, researchers delved into the latest therapeutic strategies for managing inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The paper discusses emerging treatments ranging from immune-modulating drugs and biologics to novel approaches like microRNA upregulators and stem cell therapies, highlighting the need for precision medicine in IBD care.

8 Nov 2023

Novel and emerging therapies offer new hope for patients with inflammatory bowel disease

Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) that affect the gastrointestinal tract.

7 Nov 2023

Gestational dexamethasone exposure impairs learning and memory function across generations

This new article publication from Acta Pharmaceutica Sinica B, discusses how gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effects.

15 Oct 2023

Ginger shows promise as a natural defense against autoimmune diseases

Comprehensive study reveals that whole ginger extracts have a significant impact on inhibiting neutrophil hyperactivity, a key factor in autoimmune diseases like APS and lupus. Consuming ginger for just a week showed promising results in both animal models and human trials, positioning it as a natural and affordable treatment option for a range of autoimmune disorders.

2 Oct 2023

The standard of care and recent advancements in the control of skin inflammation

Researchers discuss current therapeutic interventions for atopic dermatitis in children and adolescents.

21 Aug 2023

Pathogens in ancient DNA could explain how two civilizations collapsed

The current study has strongly indicated the presence of Y. pestis and S. enterica on the island of Crete that contributed to societal changes during 2,000 BCE.

9 Aug 2022

C-reactive protein levels predict ED risk

A recent meta-analysis aimed to describe the relationship between C-reactive protein levels and erectile dysfunction.

27 Jun 2022

McMaster-Hamburg collaboration discovers promising new antimalarial compound

A study out of the Michael G. DeGroote Institute for Infectious Disease Research at McMaster University has resulted in the discovery of a promising new antimalarial compound.

27 Oct 2021

Biomarker discovery can open door to screening newborn babies for pyridoxine-dependent epilepsy

The door has finally opened on screening newborn babies for pyridoxine-dependent epilepsy (PDE), a severe inherited metabolic disorder. This screening promises to enable better and earlier treatment of the disease.

8 Jul 2021

Pattern Computer develops novel test for 15 sec diagnosis of COVID-19

Pattern Computer,® Inc. has developed a novel test for near real-time diagnosis of SARS-CoV-2 infections.

21 Jun 2021

Shift working hours out of sync with body clock linked to greater cardiovascular risk

Working hours that deviate from an individual's natural body clock are associated with greater cardiovascular risk, according to research presented at ESC Preventive Cardiology 2021, an online scientific congress of the European Society of Cardiology (ESC).

16 Apr 2021

Study shows how a nervous system coordinates distinct behavioral outputs

For a nematode worm, a big lawn of the bacteria that it eats is a great place for it to disperse its eggs so that each hatchling can emerge into a nutritive environment.

11 Jun 2020

New Leica platform adds an additional dimension of information to confocal imaging

Leica Microsystems, has announced the launch of its flagship new confocal microscopy platform, called STELLARIS.

From Leica Microsystems GmbH 28 Apr 2020

Using drug-eluting medical devices to fight bacterial infections

Medical practitioners routinely outfit patients with devices ranging from cardiovascular stents, pacemakers, catheters, and therapeutic lenses to orthopedic, breast, dental, and cochlear implants and prostheses.

5 Dec 2019

AAD honors dermatologist for her role in treating a patient with rare skin disease

The American Academy of Dermatology has honored board-certified dermatologist Karen Wiss, MD, FAAD, as a Patient Care Hero for her role in treating a patient born with an extremely rare skin disease caused by a genetic mutation.

19 Sep 2019

Scientists develop new class of drugs to treat hereditary kidney disease

Scientists from the University of Sheffield are part of an international collaboration to develop a new class of drugs to treat a common genetic kidney disease which is a major cause of kidney failure.

18 Jun 2019

UCI discovery may lead to mitigation of side effects caused by erectile dysfunction drugs

In a study published in Science Advances magazine, researchers from the University of California, Irvine have captured, for the first time, the full-length structure of the rod photoreceptor phosphodiesterase 6 (PDE6), an enzyme that plays an indispensable role in human vision.

5 Apr 2019

Surgically-removed tumor specimens can help quickly evaluate cancer drug efficacy

Genetic differences can affect the susceptibility of cancer cells to different drugs. In a new Molecular Oncology study, investigators show that surgically-removed breast and prostate tumor specimens can be used to rapidly screen different drugs to see which ones most effectively target an individual's cancer cells.

22 Aug 2018

Drug in clinical trials for Parkinson's disease offers hope for treating heart failure

A drug currently in clinical trials for treating symptoms of Parkinson's disease may someday have value for treating heart failure, according to results of early animal studies by Johns Hopkins Medicine researchers.

20 Jul 2018