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New step towards the development of non-addictive painkillers

Opioid-containing painkillers are virtually indispensable in clinical practice and are typically used in postoperative patients and patients undergoing cancer treatment.

3 Mar 2020

Researchers solve long-standing mystery linked to contraction of heart cells

We've all felt the effects of an adrenaline rush. Faced with danger, real or perceived, the heart beats faster, breathing quickens and muscles tighten as the body prepares to fight a threat or flee from it.

23 Jan 2020

Sensitive Analysis of Sugars with HPLC-Electrochemical Detection

An interview with Dr. Kristin Folmert, Application & Academy, KNAUER Wissenschaftliche Geräte GmbH.

From KNAUER Wissenschaftliche Geräte GmbH 23 Jan 2020

Forgetful? Look at the time

An interesting new paper describes the discovery of a gene in mice that affects the degree of memory recall at various times of day. They found that this gene makes mice most forgetful at the time immediately before they wake.

18 Dec 2019

Researchers identify first gene in mice specific to memory retrieval

Can't remember something? Try waiting until later in the day. Researchers identified a gene in mice that seems to influence memory recall at different times of day and tracked how it causes mice to be more forgetful just before they normally wake up.

18 Dec 2019

Using anion exchange chromatography and electrochemical detection for determination of carbohydrates

Carbohydrates are among the most widespread organic compounds in the living nature. As monosaccharides and di-saccharides, they primarily serve the direct supply of energy in the organism. In the form of oligomers or polymers, they are used more for storage of energy or information, or take over tasks as a structural element in cell walls, primarily of plants.

From KNAUER Wissenschaftliche Geräte GmbH 3 Sep 2019

Cells and organisms evolved complex biochemical circuits that follow control theory

In the last 150 years, engineers have developed and mastered ways to stabilize dynamic systems, without lag or overshoot, using what's known as control theory.

12 Aug 2019

UC Davis researchers identify how diabetes increases risk of vascular diseases

A team of UC Davis Health scientists and physicians has identified a cellular connection between diabetes and one of its major complications - blood vessel narrowing that increases risks of several serious health conditions, including heart disease and stroke.

25 Jul 2019

Study shows how high glucose damages the vascular system

Diabetes, which is marked by increased glucose levels in the body, eventually leads to certain complications, including cardiovascular disease. Now, a new study shows a cellular connection between diabetes and blood vessel narrowing that boosts one’s risk of chronic and potentially fatal health conditions, including stroke and heart disease.

22 Jul 2019

Researchers elucidate how embryonic cells and tissues respond to force

Accumulated evidence suggests that physical force plays an important role in various developmental processes of fertilized animal eggs.

8 Mar 2019

Study shows how a novel regulatory mechanism serves as key biomarker for diabetes

A recent study led by researchers in Texas A&M University's department of nutrition and food science shows how a novel regulatory mechanism serves as an important biomarker for the development of diabetes, as well as a potential therapeutic target for its prevention.

20 Dec 2018

InSysBio evaluates tau protein phosphorylation related targets for treatment of AD

InSysBio continues to investigate the mechanisms underlying Alzheimer's disease using the quantitative systems pharmacology modeling approach. The part of QSP model describing tau protein was published in the PLOS ONE journal. This is one of more than dozen InSysBio publications in AD area during last seven years.

28 Feb 2018

Fat-busting ingredients in cinnamon

Researchers have found that certain ingredients in cinnamon can help burn fat in humans. They along with several other previous studies have noted that cinnamon – a common kitchen spice – contains cinnamaldehyde. This is an essential oil that gives the special flavor to cinnamon.

23 Nov 2017

Scientists find new drug target to improve cardiac output in heart failure patients

Researchers led by Julian E. Stelzer, PhD, associate professor in the department of physiology and biophysics at Case Western Reserve University School of Medicine, have found a new target for drug developers seeking straightforward ways to improve cardiac output in heart failure patients.

4 Apr 2017

Short-term fasting during chemotherapy may counteract side effects of common cancer drugs

A short-term fast appears to counteract increases in blood sugar caused by common cancer drugs and protect healthy cells in mice from becoming too vulnerable to chemotherapy, according to new research from the University of Southern California.

4 Apr 2017

Researchers develop optimized sensors to study biochemical underpinnings of learning and memory

Learning and memory are crucial aspects of everyday life. When we learn, our neurons use chemical and molecular signals to change their shapes and strengthen connections between neurons, a process known as synaptic plasticity.

9 Mar 2017

Factors secreted by intestinal bacteria may help prevent or treat kidney stones

Researchers have discovered that factors secreted by gut bacteria might help prevent or treat kidney stones.

14 Oct 2016

Study reveals new activation mechanism for protein kinases

Protein kinases, most scientists would agree, regulate nearly every aspect of cell life. It is no surprise, then, that having faulty protein kinases may lead to a number of human conditions, including cardiovascular diseases, cancer and diabetes.

11 Apr 2016

UNC researchers show how a genetic mutation disables molecular switch and causes autism

Last December, researchers identified more than 1,000 gene mutations in individuals with autism, but how these mutations increased risk for autism was unclear. Now, UNC School of Medicine researchers are the first to show how one of these mutations disables a molecular switch in one of these genes and causes autism.

7 Aug 2015

Study explains why COPD patients develop tolerance to roflumilast drug

Roflumilast, a drug recently approved in the United States to treat severe chronic obstructive pulmonary disease (COPD), increases the production of a protein that causes inflammation, which possibly results in patients developing a tolerance to the drug after repeated use and makes the drug less effective, according to researchers at Georgia State University, Kumamoto University and the University of Rochester Medical Center.

24 Mar 2015