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The pancreas is a gland organ in the digestive and endocrine system of vertebrates. It is both an endocrine gland producing several important hormones, including insulin, glucagon, and somatostatin, as well as an exocrine gland, secreting pancreatic juice containing digestive enzymes that pass to the small intestine. These enzymes help in the further breakdown of the carbohydrates, protein, and fat in the chyme.
Low levels of vitamin D, methylation in black teens may increase cancer risk

Low levels of vitamin D, methylation in black teens may increase cancer risk

Low levels of vitamin D in black teens correlates with low activity of a major mechanism for controlling gene expression that may increase their risk of cancer and other disease, researchers report. [More]
Nocturnal hypoxemia closely linked to diabetic microvascular complications

Nocturnal hypoxemia closely linked to diabetic microvascular complications

Examining the poorly understood link between obstructive sleep apnea (OSA) and type 2 diabetes complications, researchers identified specific measures of low blood oxygenation that are associated with impaired kidney function and diabetic nephropathy. [More]
Scientists uncover molecular identity of previously unknown Glima molecule in Type 1 diabetes

Scientists uncover molecular identity of previously unknown Glima molecule in Type 1 diabetes

Scientists have solved a decades-old medical mystery by finally identifying a previously unknown molecule which is attacked by the immune system in people with Type 1 diabetes. [More]
Study shows cancer cell death via necroptosis can drive pancreatic tumor growth

Study shows cancer cell death via necroptosis can drive pancreatic tumor growth

The most aggressive form of pancreatic cancer - often described as one of the hardest malignancies to diagnose and treat -- thrives in the presence of neighboring tumor cells undergoing a particular form of "orchestrated cell death." This is according to a major study recently published in the journal Nature. [More]
Specific oral microbiome linked to pancreatic cancer risk

Specific oral microbiome linked to pancreatic cancer risk

The presence of certain bacteria in the mouth may reveal increased risk for pancreatic cancer and enable earlier, more precise treatment. This is the main finding of a study led by researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center to be presented April 19 in New Orleans at the annual meeting of the American Association for Cancer Research. [More]
New clinical study to evaluate inexpensive drug to prevent type 1 diabetes

New clinical study to evaluate inexpensive drug to prevent type 1 diabetes

A clinical study evaluating a new hypothesis that an inexpensive drug with a simple treatment regimen can prevent type 1 diabetes will be launched in Dundee tomorrow. [More]
Study points to novel way to treat diabetes in some patients

Study points to novel way to treat diabetes in some patients

Blocking the hormone that raises sugar levels in the blood could increase insulin levels while keeping blood sugar levels down. [More]
Transplanted human islets prevent hypoglycemic events in Type 1 diabetes patients

Transplanted human islets prevent hypoglycemic events in Type 1 diabetes patients

Northwestern Medicine researchers are co-investigators in a breakthrough clinical trial that found transplanted human islets prevent hypoglycemic events and provide excellent glycemic control for patients with Type 1 diabetes with severe hypoglycemia. [More]
Low-carbohydrate diet helps reduce growth of glioblastoma tumor cells in mouse models

Low-carbohydrate diet helps reduce growth of glioblastoma tumor cells in mouse models

University of Florida Health researchers have slowed a notoriously aggressive type of brain tumor in mouse models by using a low-carbohydrate diet. [More]
Newly developed implantable device can deliver chemotherapy drugs directly to pancreatic tumors

Newly developed implantable device can deliver chemotherapy drugs directly to pancreatic tumors

Pancreatic cancer is the third leading cause of cancer deaths in the United States, in part because it is very difficult for chemotherapy drugs to reach the pancreas, which is located deep within the abdomen. [More]
Phenotypic personalized medicine can identify a person's optimal drug, dose combinations

Phenotypic personalized medicine can identify a person's optimal drug, dose combinations

For decades, doctors and scientists have predicted that personalized medicine — tailoring drug doses and combinations to people's specific diseases and body chemistry — would be the future of health care. [More]
WHO marks annual World Health Day, calls for global action on diabetes

WHO marks annual World Health Day, calls for global action on diabetes

The number of people living with diabetes has almost quadrupled since 1980 to 422 million adults, with most living in developing countries. Factors driving this dramatic rise include overweight and obesity, WHO announced ahead of World Health Day. [More]
Immune cell with 'Superman' power could lead to novel therapies for type 1 diabetes

Immune cell with 'Superman' power could lead to novel therapies for type 1 diabetes

A new study led by scientists at The Scripps Research Institute (TSRI) reveals a previously unknown type of immune cell. The discovery opens new avenues in the effort to develop novel therapies for autoimmune diseases such as type 1 diabetes. [More]
Liraglutide drug makes highly desirable foods less appealing to people

Liraglutide drug makes highly desirable foods less appealing to people

Understanding the motivations that drive humans to eat is an important consideration in the development of weight loss therapies. Now a study led by researchers at Beth Israel Deaconess Medical Center helps explain how the diabetes and weight loss drug liraglutide acts on brain receptors to make enticing foods seems less desirable. [More]
Oral Salmonella-based vaccine could prevent Type 1 diabetes

Oral Salmonella-based vaccine could prevent Type 1 diabetes

A combined vaccine therapy including live Salmonella is a safe and effective way to prevent diabetes in mice and may point to future human therapies, a new study finds. The results will be on Sunday, April 3, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston. [More]
New promising therapy may improve curative potential of islet transplant for Type 1 diabetes

New promising therapy may improve curative potential of islet transplant for Type 1 diabetes

New research suggests pretreating cells with a peptide hormone may improve the success rate of pancreatic islet cell transplants, a procedure that holds great promise for curing Type 1 diabetes. The results will be presented Saturday, April 2, at the Endocrine Society's annual meeting, ENDO 2016, in Boston. [More]
European researchers aim to spare people with type 1 diabetes from lifelong insulin therapy

European researchers aim to spare people with type 1 diabetes from lifelong insulin therapy

More and more children in Europe and the USA are suffering from diabetes. A Group of European Researchers has now joined forces under the leadership of the Gothe University Frankfurt. They are searching for a new method in order to spare people with Diabetes type 1 from lifelong insulin therapy. [More]
BIDMC investigators identify precise 5-gene classifier for discriminating early pancreatic cancer

BIDMC investigators identify precise 5-gene classifier for discriminating early pancreatic cancer

Pancreatic cancer, the fourth leading cause of cancer death in the United States, is often diagnosed at a late stage, when curative treatment is no longer possible. A team led by investigators at Beth Israel Deaconess Medical Center has now identified and validated an accurate 5-gene classifier for discriminating early pancreatic cancer from non-malignant tissue. [More]
Findings could help explain origin of type 2 diabetes in children of obese mothers

Findings could help explain origin of type 2 diabetes in children of obese mothers

A new study led by researchers at The Saban Research Institute of Children's Hospital Los Angeles reports that the presence of leptin - a hormone secreted by fat cells that is critical to maintaining energy balance in the body -- inhibits the prenatal development of neuronal connections between the brain and pancreas. The findings could help explain the origin of type 2 diabetes, particularly in children of obese mothers. [More]
Neurons in hypothalamus help maintain blood glucose levels, study finds

Neurons in hypothalamus help maintain blood glucose levels, study finds

To learn what different cells do, scientists switch them on and off and observe what the effects are. There are many methods that do this, but they all have problems: too invasive, or too slow, or not precise enough. Now, a new method to control the activity of neurons in mice, devised by scientists at Rockefeller University and Rensselaer Polytechnic Institute, avoids these downfalls by using magnetic forces to remotely control the flow of ions into specifically targeted cells. [More]
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