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The pancreas is a gland organ in the digestive and endocrine system of vertebrates. It is both an endocrine gland producing several important hormones, including insulin, glucagon, and somatostatin, as well as an exocrine gland, secreting pancreatic juice containing digestive enzymes that pass to the small intestine. These enzymes help in the further breakdown of the carbohydrates, protein, and fat in the chyme.
New research collaboration aims to advance clinical trials of Cell Pouch System in people with type 1 diabetes

New research collaboration aims to advance clinical trials of Cell Pouch System in people with type 1 diabetes

A new research funding agreement between the Juvenile Diabetes Research Foundation and Sernova, a clinical-stage regenerative medicine biotech, aims to address people with severe type 1 diabetes (T1D) who are hypoglycemia unaware, a condition in which a person with diabetes does not experience the usual early warning symptoms of hypoglycemia (low blood sugar) following an insulin injection. [More]
Study suggests failure of specialised beta cells may lead to diabetes

Study suggests failure of specialised beta cells may lead to diabetes

The significant role of beta cell 'hubs' in the pancreas has been demonstrated for the first time, suggesting that diabetes may due to the failure of a privileged few cells, rather than the behaviour of all cells. [More]
Risk of hypoglycemia differs between SU agents, study reveals

Risk of hypoglycemia differs between SU agents, study reveals

Adding sulphonylureas (SUs) to metformin remains a commonly used strategy for treating type 2 diabetes, but individual SUs differ and may confer different risks of abnormally low blood sugar, or hypoglycemia. SUs-which include newer generation agents such as gliclazide, glipizide, glimepiride, and glibenclamide-stimulate the production of insulin in the pancreas and increase the effectiveness of insulin in the body. [More]
Scientists identify marker that subdivides insulin-producing beta cells of the pancreas

Scientists identify marker that subdivides insulin-producing beta cells of the pancreas

The marker Flattop subdivides the insulin-producing beta cells of the pancreas into those that maintain glucose metabolism and into immature cells that divide more frequently and adapt to metabolic changes. [More]
Immunotherapy drug combination shows prominent therapeutic effect against advanced and metastatic cancers in mice

Immunotherapy drug combination shows prominent therapeutic effect against advanced and metastatic cancers in mice

A drug combination designed to enhance the immune system's ability to zero in and attack cancer cells has shown a pronounced therapeutic effect against advanced and metastatic cancers in mice, according to a Mayo Clinic study, published in the July 12 edition of the online journal Oncotarget. [More]
Research on Flattop protein could provide starting point for regenerative diabetes therapies

Research on Flattop protein could provide starting point for regenerative diabetes therapies

The marker Flattop subdivides the insulin-producing beta cells of the pancreas into those that maintain glucose metabolism and into immature cells that divide more frequently and adapt to metabolic changes. [More]
MGH researchers discover how obesity increases inflammation, desmoplasia in PDAC patients

MGH researchers discover how obesity increases inflammation, desmoplasia in PDAC patients

Massachusetts General Hospital investigators have discovered the mechanism by which obesity increases inflammation and desmoplasia - an accumulation of connective tissue - in the most common form of pancreatic cancer. [More]
Liraglutide drug lowers blood sugar levels in diabetic patients taking large doses of insulin

Liraglutide drug lowers blood sugar levels in diabetic patients taking large doses of insulin

When Amy Sweat was 19 years old, while she was in the hospital recovering from surgery, she was diagnosed with Type 2 diabetes. Ms. Sweat was treated for her diabetes, first on oral drugs, then on increasingly larger doses of insulin, but the years went by and she never was able to achieve good blood sugar control. [More]
MIT engineers develop new way to visualize RNA molecules in higher resolution

MIT engineers develop new way to visualize RNA molecules in higher resolution

Cells contain thousands of messenger RNA molecules, which carry copies of DNA's genetic instructions to the rest of the cell. MIT engineers have now developed a way to visualize these molecules in higher resolution than previously possible in intact tissues, allowing researchers to precisely map the location of RNA throughout cells. [More]
Immunotherapy in conjunction with drugs could be effective in treating pancreatic cancer

Immunotherapy in conjunction with drugs could be effective in treating pancreatic cancer

While immune therapy has proven effective in treating certain types of cancer, especially lung cancer and melanoma, tumors of the pancreas remain among the most difficult to treat and, so far, are impervious to immune-based therapies. [More]
Study links proteins involved in cell division to insulin signaling

Study links proteins involved in cell division to insulin signaling

Proteins that play key roles in the timing of cell division also moonlight in regulating blood sugar levels, UT Southwestern Medical Center researchers have found. [More]
New study may help develop effective medication for severe pain

New study may help develop effective medication for severe pain

The nerve cells that transmit pain signals in the body are called nociceptors. When activated they release pro-inflammatory neuropeptides. In order to recognise harmful external influences, nociceptors are equipped with a wide range of receptors. [More]
Appetite hormone CART helps increase insulin secretion, reduce glucagon production

Appetite hormone CART helps increase insulin secretion, reduce glucagon production

The study shows that the appetite hormone CART not only controls the sensation of satiety, but it also helps increase insulin secretion and decrease glucagon production. [More]
Excess or insufficient sleep may increase diabetes risk in men

Excess or insufficient sleep may increase diabetes risk in men

Men who sleep either fewer or more hours than average may face a greater risk of developing diabetes, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. [More]
Researchers identify new potential target for pancreatic cancer treatment

Researchers identify new potential target for pancreatic cancer treatment

Using an innovative approach to identify a cancer's genetic vulnerabilities by more swiftly analyzing human tumors transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell Reports. [More]
Study shows Alzheimer's disease can lead to diabetes

Study shows Alzheimer's disease can lead to diabetes

Drugs used to treat diabetes could also be used to treat Alzheimer's disease, and vice versa, according to new research from the University of Aberdeen. [More]
Scientists aim to explore how gestational diabetes can put babies at lifelong risk for cardiovascular disease

Scientists aim to explore how gestational diabetes can put babies at lifelong risk for cardiovascular disease

Gestational diabetes can put babies at a lifelong risk for cardiovascular disease, and scientists want to better understand how. [More]
Researchers uncover potential therapeutic benefit of PI3K protein in PanNETs

Researchers uncover potential therapeutic benefit of PI3K protein in PanNETs

Researchers from the 'Angiogenesis signaling pathways' research group of the Institute of Biomedical Investigation of Bellvitge, led by Dr. Mariona Graupera, have unveiled the potential therapeutic benefit of a selective inhibitior of the PI3-kinase (PI3K) protein in pancreatic neuroendocrine tumors (PanNETs). [More]
MPC outperforms PID in automated insulin delivery for patients with type 1 diabetes mellitus

MPC outperforms PID in automated insulin delivery for patients with type 1 diabetes mellitus

The so-called artificial pancreas — an automated insulin delivery system for people with type 1 diabetes mellitus — uses an advanced control algorithm to regulate how much insulin a pump should deliver and when. Regulating glucose is challenging because levels respond to a wide-array of variables, including food, physical activity, sleep, stress, hormones, metabolism and more. [More]
Molecular imaging technique could help optimize radiotherapy dose to combat NETs

Molecular imaging technique could help optimize radiotherapy dose to combat NETs

Aggressive neuroendocrine cancer is something of a dark horse--a rare, elusive and persevering force linked to discouraging long-term survival rates. [More]
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