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Studies shed light on propensity for habit formation in obsessive-compulsive disorder

Studies shed light on propensity for habit formation in obsessive-compulsive disorder

Two new studies published this week in Biological Psychiatry shed light on the propensity for habit formation in obsessive-compulsive disorder (OCD). These studies suggest that a tendency to develop habits, i.e., the compulsive component of the disorder, may be a core feature of the disorder rather than a consequence of irrational beliefs. [More]
New lab at the Nencki Institute conducts research on neurodegenerative diseases

New lab at the Nencki Institute conducts research on neurodegenerative diseases

The Laboratory of Preclinical Studies of Higher Standard, the newest lab of the Neurobiology Center at the Nencki Institute in Warsaw, Poland, will conduct basic research aimed to explain molecular mechanisms responsible for neurodegenerative diseases. [More]
FDA clears Omeros' OMS721 IND for inhibition of complement‑mediated TMAs

FDA clears Omeros' OMS721 IND for inhibition of complement‑mediated TMAs

Omeros Corporation today announced that its Investigational New Drug Application (IND) to evaluate OMS721 for the inhibition of complement‑mediated thrombotic microangiopathies (TMAs) has been cleared by the U.S. Food and Drug Administration. [More]
International scientists identify novel genetic defects that induce oesophageal cancer

International scientists identify novel genetic defects that induce oesophageal cancer

A team of scientists from the Cancer Science Institute of Singapore at the National University of Singapore and National University Cancer Institute Singapore, and their collaborators from the Cedars-Sinai Medical Centre, UCLA School of Medicine, demonstrated that a number of novel genetic defects are able to induce oesophageal cancer. [More]
Primary negative symptoms worsen functioning in schizophrenia

Primary negative symptoms worsen functioning in schizophrenia

Primary negative symptoms adversely affect social, vocational and recreational functioning in patients with schizophrenia, even when the potential influence of secondary negative symptoms has been accounted for, Canadian researchers report. [More]
Nine fellows selected to receive Dennis Weatherstone Predoctoral Fellowship for next two years

Nine fellows selected to receive Dennis Weatherstone Predoctoral Fellowship for next two years

​Autism Speaks, the world's leading autism science and advocacy organization, today announced the sixth class of The Dennis Weatherstone Predoctoral Fellows funded by the Stavros Niarchos Foundation. [More]

Ironwood Pharmaceuticals starts Phase IIa clinical study of IW-3718 for gastroesophageal reflux disease

Ironwood Pharmaceuticals, Inc. (NASDAQ: IRWD) announced today that dosing has begun in its Phase IIa clinical study of its investigational compound IW-3718 in patients suffering from gastroesophageal reflux disease (GERD) who have not responded adequately to treatment with a proton pump inhibitor (PPI). Data are expected in the first half of 2015. [More]

Vitamin D receptor gene variant protects against male LUTS

An international research effort aimed at identifying the genetic basis of lower urinary tract symptoms has identified five candidate genes, one of which – encoding the vitamin D receptor – is consistently protective against these symptoms in men. [More]

Nerve growth factor may be dynamic marker of OAB pathophysiology

Urine levels of nerve growth factor fluctuate in line with changes in bladder pathophysiology, a 5-year study of people with overactive bladder has found. [More]
Findings suggest that IBS is linked to detectable gut microbiota alterations

Findings suggest that IBS is linked to detectable gut microbiota alterations

Irritable bowel syndrome (IBS) belongs to the most widespread diseases in Western countries, causing up to sixty per cent of the workload of gastrointestinal physicians. One of the most frequent symptoms of IBS is bloating, which reduces quality of life considerably as patients perceive it as particularly bothersome. [More]
Scientists use novel metagenomic approaches to characterize microbial communities that reside in human gut

Scientists use novel metagenomic approaches to characterize microbial communities that reside in human gut

The gut microbiota contains a vast number of microorganisms from all three domains of life, including bacteria, archaea and fungi, as well as viruses. These interact in a complex way to contribute towards both health and the development of disease - interactions that are only now being elucidated thanks to the application of advanced DNA sequencing technology in this field. [More]
Inflammation and stress combine in bipolar and schizophrenia subtypes

Inflammation and stress combine in bipolar and schizophrenia subtypes

Researchers have found that some individuals with bipolar disorder or schizophrenia have combined stress response and immune dysfunctions. [More]

Interhemispheric disconnectivity highlighted in bipolar disorder

Research shows that patients with bipolar I disorder have reduced white matter integrity, including in the corpus callosum, which connects the brain’s hemispheres. [More]
New treatments for depression on the horizon

New treatments for depression on the horizon

New insights into the physiological causes of depression are leading to treatments beyond common antidepressants such as Prozac and Zoloft, researchers are reporting in the in the journal Current Psychiatry. [More]

Rhythmicity of activity linked to bipolar mania

Circadian rhythm disturbances are associated with bipolar disorder, and particularly with mania, indicate study findings. [More]
Rare and de novo mutations flesh out schizophrenia picture

Rare and de novo mutations flesh out schizophrenia picture

Two studies in Nature show that rare disruptive and de novo mutations may contribute to the pathophysiology of schizophrenia. [More]

6-month-old infants later diagnosed with autism divert gaze from facial features

From birth, infants naturally show a preference for human contact and interaction, including faces and voices. These basic predispositions to social stimuli are altered in individuals diagnosed with autism spectrum disorders (ASD). [More]
Scientists, clinicians to examine role of human gut microbiota in digestive and overall health

Scientists, clinicians to examine role of human gut microbiota in digestive and overall health

​The microbial communities that reside in the human gut and their impact on human health and disease are one of the most exciting new areas of research today. To address the most recent advances in this rapidly developing field, scientists and health-care professionals from all over the world will come together at the Gut Microbiota for Health World Summit in Miami, Florida, on March 8 and 9, 2014. [More]

Cortical thickness may distinguish bipolar from unipolar disorder

Patients with depression have areas of reduced cortical thickness, with clear distinctions between those with bipolar disorder and major depressive disorder, report US researchers. [More]
BrainScope receives award from GE and NFL to enhance portable concussion assessment system

BrainScope receives award from GE and NFL to enhance portable concussion assessment system

BrainScope Company, Inc. today announced that it has received an award from GE and the National Football League to further enhance its portable concussion assessment system by combining imaging biomarkers with its brainwave technology. [More]