Pericytes News and Research

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Novel "Tissue-in-a-CUBE" model mimics blood-brain barrier for drug testing

A research team at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan has succeeded in establishing a model of the blood-brain barrier using modularized tissue derived from human cells.

28 Feb 2024

Discovery of bicarbonate-sensing receptor offers therapeutic insights into ischemic stroke treatment

Researchers have identified this receptor in brain mural cells that regulates reperfusion injury.

27 Feb 2024

Ludwig scientists deconstruct the blood supply of brain metastases

A Ludwig Cancer Research study has generated a granular portrait of how the cellular and molecular components of the blood vessels that feed brain metastases of melanoma and lung and breast cancers differ from those of healthy brain tissue, illuminating how they help shape the internal environment of tumors to support cancer growth and immune evasion.

19 Jan 2024

Revolutionary approach links protein analysis and single-cell study to uncover disease mechanisms

Integrated liquid-biopsy proteomics with single-cell transcriptomics from ocular cell types.

24 Oct 2023

Study investigates the pathophysiological mechanisms of PASC after COVID-19

Researchers investigated early pathophysiological mechanisms potentially underlying PASC post-SARS-CoV-2 infection.

4 Sep 2023

Engineered adeno-associated virus vector yields high transduction of the brain vasculature

Researchers have developed an engineered adeno-associated virus (AAV) vector that yields high transduction of brain vascular pericytes and smooth muscle cells.

24 Aug 2023

Scientists identify signal essential for blood-brain barrier formation

What makes the vital layer of protective cells around the brain and spinal cord -; the blood-brain barrier -; more or less permeable has been one of the more mystifying questions in neuroscience.

12 Jul 2023

World's largest map of breast tissue provides an unprecedented understanding of mammary biology

A new study led by researchers at The University of Texas MD Anderson Cancer, University of California, Irvine and Baylor College of Medicine has created the world's largest and most comprehensive map of normal breast tissue, providing an unprecedented understanding of mammary biology that may help identify therapeutic targets for diseases such as breast cancer.

28 Jun 2023

The impact of common viral infections on blood-brain barrier function and insulin sensitivity

A new study discusses the impact of several human viruses on blood-brain barrier function and insulin sensitivity.

31 Jan 2023

Special vascular cells sense when the brain region needs energy

When we smell hot dogs, it may trigger memories of backyard barbeques or attending baseball games during childhood.

26 Jan 2023

Healthy gene found in centenarians can reverse the decline of heart performance in older people

An anti-aging gene discovered in a population of centenarians has been shown to rewind the heart's biological age by 10 years.

23 Jan 2023

Free spike proteins in the blood appear to play a role in myocarditis post-COVID mRNA vaccine

A recent study published in the journal Circulation examines the immunological picture in this scenario, looking for clues to the etiology of this rare and potentially serious complication.

5 Jan 2023

NIH scientists use patient stem cells and 3D bioprinting to produce eye tissue

Scientists used patient stem cells and 3D bioprinting to produce eye tissue that will advance understanding of the mechanisms of blinding diseases.

22 Dec 2022

How human cell atlases provide the missing links between genes, diseases and therapies

A Nature Medicine journal perspective article describes the potential of cell atlases in shaping the future of medicine. Providing the missing link between genes and diseases, single-cell atlases make it possible to develop more precise and specific diagnostic tools by understanding the mechanisms of complex diseases.

12 Dec 2022

Pericytes News and Research

Novel "Tissue-in-a-CUBE" model mimics blood-brain barrier for drug testing

Discovery of bicarbonate-sensing receptor offers therapeutic insights into ischemic stroke treatment

Ludwig scientists deconstruct the blood supply of brain metastases

Revolutionary approach links protein analysis and single-cell study to uncover disease mechanisms

Study investigates the pathophysiological mechanisms of PASC after COVID-19

Engineered adeno-associated virus vector yields high transduction of the brain vasculature

Scientists identify signal essential for blood-brain barrier formation

World's largest map of breast tissue provides an unprecedented understanding of mammary biology

The impact of common viral infections on blood-brain barrier function and insulin sensitivity

Special vascular cells sense when the brain region needs energy

Healthy gene found in centenarians can reverse the decline of heart performance in older people

Free spike proteins in the blood appear to play a role in myocarditis post-COVID mRNA vaccine

NIH scientists use patient stem cells and 3D bioprinting to produce eye tissue

How human cell atlases provide the missing links between genes, diseases and therapies

What is the impact of COVID-19 and organophosphates on cardiac health?

Study uncovers molecular changes in the brain’s blood vessels caused by Alzheimer’s susceptibility gene

Lack of strength in smooth muscle cells leads to malformations of the blood vessels, study shows

Researchers develop a potential way to tackle one of the underlying causes of asthma

Researchers reveal possible way to treat newborns with rare genetic lung condition

Substantial SARS-CoV-2 infection in perivascular cells of inflamed blood vessels

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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